Department Publications

Publications from 2011

Pugacheva, EN, Bluestein SA, Feng Y, Longmore GD, and Golemis EA. "A HEF1-Ajuba protein complex synergistically activates Aurora-A kinase." (Manuscript in preparation).

Pugacheva, EN and Golemis E.A. "Tissue specific activation of AurA kinase in response to adhesion keys." (Manuscript in preparation).

Cieply B, Riley P, Pifer P, Widmeyer J, Addison JB, Ivanov AV, Denvir J, Frisch SM. Suppression of the epithelial-mesenchymal transition by grainyhead-like-2. Cancer Res. 2012. in press.

White D, Rafalska-Metcalf IU, Ivanov AV, Corsinotti A, Peng H, Lee SC, Trono D, Janicki SM, Rauscher FJ 3r. The ATM substrate KAP1 controls DNA repair in heterochromatin: Regulation by HP1 proteins and Serine 473/824 phosphorylation. Mol Cancer Res. 2011 Dec 28. [Epub ahead of print]

Kumar S, Park SH, Cieply B, Schupp J, Killiam E, Zhang F, Rimm DL, Frisch SM. A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition. Mol Cell Biol. 2011 Oct;31(19):4036-51. Epub 2011 Jul 11.

Frisch SM, Cieply B, Riley P 4th, Pifer PM, Widmeyer J, Addison JB, Ivanov AV, Denvir J. SUPPRESSION OF THE EPITHELIAL-MESENCHYMAL TRANSITION BY GRAINYHEAD-LIKE-2. Cancer Res. 2012 Feb 29. [Epub ahead of print]

Singh SK, O'Hara B, Talukder JR, Rajendran VM. Aldosterone induces active K+ secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon. Am J Physiol Cell Physiol. 2012 Feb 8. [Epub ahead of print]

Basalingappa KM, Rajendran V.M., Wonderlin W.F. Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G905-11. Epub 2011 Aug 25.

Zhou X, Agazie Y.M. The signaling and transformation potency of the overexpressed HER2 protein is dependent on the normally-expressed EGFR. Cell Signal. 2012 Jan; 24(1):140-50. Epub 2011 Sep 3.

Kohan AB, Qing Y, Cyphert HA, Tso P, Salati L.M. Chylomicron remnants and nonesterified fatty acids differ in their ability to inhibit genes involved in lipogenesis in rats. J Nutr. 2011 Feb; 141(2):171-6. Epub 2010 Dec 15.

Smith D. M. *, Fraga H., Reis C., Goldberg A. L.* ATP binds to proteasomal ATPases in pairs with distinct functional effects implying an ordered reaction cycle. (2011) Cell, 144, 526-38 *Corresponding Author

Bader M., Benjamin S., Wapinsky O. L., Smith D. M. , Goldberg A. L., and Steller H. A conserved F- box–regulatory complex controls proteasome activity and sperm differentiation in Drosophila. (2011) Cell, 145 371-382.

Deriziotis P.*, Andre R.*, Smith D. M. *, Goold R., Kinghorn K. J., Kristiansen M. Nathan J.A., Rosenzweig R., Krutauz D., Glickman M. H., Collinge J., Goldberg A. L., Tabrizi S. J. Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. (2011). EMBO Journal, 30, 3065-77 *These authors contributed equally to this work

Md. A. Motaleb, S. Z. Sultan, M. R. Miller, C. Li, and N. W. Charon “CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated intermediate” J. Bacteriology, 193(13): 3332-3341 (2011).

S. Z. Sultan, J. E. Pitzer, T. Boquoi, G. Hobbs, M.R. Miller and Md. A Motaleb “Analysis of the HD-GYP domain cyclic-di-GMP phosphodiesterase reveals a role in motility and enzootic life cycle of Borrelia burgdorferi.” Infect. Immun. (2011).

M.R. Miller and Petar Denoble “Microbial Hazards: a threat to scuba divers?” Alert Diver, Dec 15: 1 - 6 (2011).

Publications from 2010

Bullock KE, Petros WP, Younis I, Uronis HE, Morse MA, Blobe GC, Yousuf Zafar S, Gockerman JP, Lager JJ, Truax R, Meadows KL, Howard LA, O'Neill MM, Broadwater G, Hurwitz HI, Bendell JC. A phase I study of bevacizumab (B) in combination with everolimus (E) and erlotinib (E) in advanced cancer (BEE) . Cancer Chemother Pharmacol. 2011 Feb;67(2):465-74. Epub 2010 Nov 16

Castaneda C, Meadows KL, Truax R, Morse MA, Kaufmann SH, Petros WP, Zhu Y, Statkevich P, Cutler DL, Hurwitz HI. Phase I and Pharmacokinetic Study of Lonafarnib, SCH66336, using a 2-week on, 2-week off schedule in patients with advanced solid tumors. Cancer Chemother Pharmacol 2011 Feb;67(2):455-63. Epub 2010 Oct 24.

Dugan, E., Truax, R., Meadows, K. L., Nixon, A. B., Petros, W. P., Favaro, J., Fernando, N. H., Morse, M. A., Blobe, G. C., and Hurwitz, H. I. A phase I dose-escalation study of imatinib mesylate (Gleevec/STI571) plus capecitabine (Xeloda) in advanced solid tumors. Anticancer Res. 2010;30:1251-1256.

Lesinski GB, Carson WE, Repasky EA, Wei W-Z, Kalinski P, Lotze MT, June C, Petros W, Muthusamy N, Olencki T. Meeting Report: The 13th Annual Meeting of the Translational Research Cancer Centers Consortium (TrC3); Immune Suppression and the Tumor Microenvironment, March 1-2, 2010. J Immunother 2010;33:659-62.

McMahon N, Cheng TY, Beasley GM, Spasojevic I, Petros W, Augustine CK, Zipfel P, Padussis JC, Sanders G, Tyler DS. Optimizing melphalan pharmacokinetics in regional melanoma therapy: does correcting for ideal body weight alter regional response or toxicity? Ann Surg Oncol 2009;16:953-61.

Abraham J, Keresztury J, Azar J, Monga M, Bowers T, Jones MP, Tirona MT, Pollock J, Coonley C, Jubelirer S, Frame J, Fogg P, Getto M, Filburn S, Naim J, Petros W, Hall S, Remick SC. Building a statewide clinical trials network for West Virginia. West Va Med J 2009;October:6-11.

Younis IR, Malone S, Friedman HS, Schaaf LJ, Petros WP. Enterohepatic recirculation model of irinotecan (CPT-11) & metabolite pharmacokinetics in patients with glioma. Cancer Chemother Pharmacol 2009;63:517-524

Petros WP & Sharma M. Pharmacogenomics of Hematological Malignancies. In: McLeod H, ed. Pharmacogenomics: Applications to Patient Care, American College of Clinical Pharmacy. Second Edition, 135-142, 2009.

Dugan E, Truax R, Meadows KL, Blobe GC, Morse MA, Fernando NH, Gockerman JP, Petros WP, Hurwitz HI. Phase I dose escalation study of gemcitabine plus irinotecan in advanced solid tumors. Anticancer Res 2009;29:5149-53.

Lin CC, Liu LZ, Addison JB, Ivanov AV, Ruppert JM. (2011) A KLF4-miRNA-206 Autoregulatory Feedback Loop can Promote or Inhibit Protein Translation Depending upon Cell Context. Molecular and Cellular Biology, 25 Apr (Epub ahead of print). PMID: 21518959. Link: http://www.ncbi.nlm.nih.gov/pubmed/21518959.

Iyengar S, Ivanov AV, Jin VX, Rauscher FJ, Farnham PJ. (2011) Functional analysis of KAP1 genomic recruitment. Molecular and Cellular Biology, 22 Feb (Epub ahead of print). PMID: 21343339. Link: http://www.ncbi.nlm.nih.gov/pubmed/21343339.

Christiansen JR, Kolandaivelu S, Bergo MO, Ramamurthy V. RCE1-mediated endoproteolysis is required for trafficking of rod PDE6 to photoreceptor outer segments. Proceedings of National Academy of Sciences (2011), (Accepted for publication).

Kirschman LT, Kolandaivelu S, Frederick JM, Dang L, Goldberg AF, Baehr W, Ramamurthy V. The Leber congenital amaurosis protein, AIPL1, is needed for the viability and functioning of cone photoreceptor cells. Link Hum Mol Genet (2010), 19(6):1076-87. Epub 2009 Dec 30.

Kolandaivelu S, Huang J, Hurley JB, Ramamurthy V. AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly. Link J Biol Chem (2009), 284(45):30853-61.

Edrington T, Sokolov M, Boesze-Battaglia K (2011) "Peripherin/rds Co-distributes with Putative Binding Partners in Basal Rod Outer Segment Disks" Experimental Eye Research in press

Posokhova E, Song H, Belcastro M, Higgins L, Bigley L, Michaud N, Martemyanov K, Sokolov M (2011) "Disruption of Chaperonin Containing TCP-1 Function Affects Protein Networks Essential for Rod Outer Segment Morphogenesis and Survival" Molecular and Cellular Proteomics, 10(1): M110.000570

Linton JD, Holzhausen LC, Babai N, Song H, Miyagishima KJ, Stearns G, Lindsay K, Wei J, Chertov AO, Peters T, Caffe R, Pluk H, Seeliger M, Tanimoto N, Fong K, Bolton L, Kuok LTD, Sweet IR, Bartoletti TM, Rady R, Travis GH, Zagotta WN, Van der Zee C, Sampath AP, Sokolov M, Thoreson W, Hurley JB (2010) "Flow of Energy in Outer Retina in Darkness and in Light" Proc. Natl. Acad. Sci. USA 107: 8599-860

Kanan Y, Matsumoto H, Song H, Sokolov M, Anderson R, Rajala R (2010) "Insulin Receptor Signaling Regulates the Activity of Retinal Serine/Threonine Phosphatases, PHLPP and PHLPPL" Journal of Neurochemistry 113: 477-488

Lauren T. Gehman, Peter Stoilov, Jamie Maguire, Andrey Damianov, Chia-Ho Lin, Lily Shiue, Manuel Ares Jr., Istvan Mody, and Douglas L. Black (2011) "The splicing regulator Fox-1/A2BP1 controls neuronal excitation in the mammalian brain"., Nature Genetics, Accepted for publication.

Stoilov P (2011) Chapter 46: 'Screening for Alternative Splicing Modulators', in 'Alternative pre-mRNA Splicing Theory and Protocols', editors Stamm S., Chris, S., Luhrmann R., ISBN-10: 3-527-32606-5, Wiley-VCH, In press

Brian K. Washburn, Andrew E. Levin, Kristen Hennessy, M. R. Miller "Identification of Bacteria in Scuba Divers’ Rinse Tanks", Undersea and Hyperbaric Medicine, 37(4) 233-240 (2010).

S. Z. Sultan, J. E. Pitzer, M. R. Miller and Md. A. Motaleb "Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-GMP in motility and virulence" Molecular Microbiology, Molecular Microbiology, 77(1):128-42 (2010).

Liang XB, Guo Y, Figg WD, Fojo AT, Mueller MD and Yu JJ. "The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor." Chemotherapy Research and Practice Platinum Analogues in Chemotherapy, Volume 2011 (2011), Article ID 715469, 8 pages, doi:10.1155/2011/715469.

Yu JJ, Fu PF, Pink JJ, Dawson D, Wasman J, Orem J, Mwanda WO, Zhu HL, Liang XB, Guo Y, Petros WP, Mitsuyasu RT, Wabinga H and Remick SC. "HPV Infection and EGFR Activation/Alteration in HIV-Infected East African Patients with Conjunctival Carcinoma." PLoS ONE, 5(5): e10477, May 2010.

Clump DA, Yu JJ, Cho YJ, Gao R, Jett J, Zot H, Cunnick JM, Snyder B, Clump AC, Dodrill M, Gannett P, Coad JE, Shurina R, Figg WD, Reed E and Flynn DC. "A polymorphic variant of AFAP-110 enhances cSrc activity." Translational Oncology, 3(4):276-285, 2010.

Van Dyke, Knox; Jabbour, Nabil; Hoeltdke, Robert; Van Dyke Chris; and Van Dyke ,Mark, "Oxidative/Nitrosative (O/N) Stresses Trigger Diabetes I-Preventable in Streptozotocin Rats – and Detectable in Human Disease", in Annals of The New York Academy of Sciences ,1203,138-145, Aug 2010.

Hoeldtke Robert,D; Bryner, Kimberly, D.; Van Dyke, Knox; "Oxidative stress and autonomic nerve function in early type I diabetes in Clinical Autonomic Research" published on line pp 1-10 September 25, 2010.

M.D. Schaller and S.M. Frisch. 2010. Commentary on Tanjoni, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther., in press

He. X. and Ma, Q. (2010) Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic-sensing and suppression of nuclear factor erythroid 2-related factor 2. J Pharmacol Exp Ther 332(1), 66-75

Ma, Q. (2010) Transcriptional response to oxidative stress: pathological and toxicological implications. Pharmacology and Therapeutics 125(3), 376-393

Bi, Y., Li, Y., Kong, M., Xiao, X., Zhao, Z., Li, L., He, X., and Ma, Q. (2010) Gene expression in benzene-exposed workers by microarray analysis of peripheral blood mononucleocytes: induction and silencing of CYP4F3 and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chemico-Biological Interactions 184(1-2), 207-211

Stuart F. Goldstein, Chunhao Li, Jun Liu, M.R. Miller, Md. Abdul Motaleb, Steven J. Norris, Ruth E. Silversmith, Charles W. Wolgemuth and Nyles W. Charon "The Chic Motility and Chemotaxis of Borrelia burgdorferi" in

A.K. Sood, G.N. Armaiz-Pena, J. Halder, A.M. Nick, R.L. Stone, W. Hu, A.R. Carroll, W.A. Spannuth, M.T. Deavers, J.K. Allen, L.Y. Han, A.A. Kamat, M.M.K. Shahzad, B.W. McIntyre, C.M. Diaz-Montero, N.B. Jennings, Y.G. Lin, W.M. Merritt, K. DeGeest, P.E. Vivas-Mejia, G.Lopez-Berestein, M.D. Schaller, S.W. Cole, and S.K. Lutgendorf. 2010. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin. Invest 120:1515-1523.

M.D. Schaller. 2010. Cellular Functions of FAK Kinases: Insight into Molecular Mechanisms and Novel Functions. J Cell Sci. 123:1007-1013.

Zhu HL and Yu JJ. Gene expression patterns in the histopathological classification of epithelial ovarian cancer. Experimental and Therapeutic Medicine, 1(1): 187-192, 2010.

Publications from 2009

Zhou, X. and Agazie, YM (2009), Molecular Mechanism for SHP2 in Mediating HER2-Induced Signaling and Cell Transformation, In Press, JBC.

Bhatnagar, S., Damron, H. A., and Hillgartner, F. B. (2009) Fibroblast growth factor 19: A novel factor that inhibits hepatic fatty acid synthesis. J. Biol. Chem. 284, 10023-10033.

Peng H., Ivanov, A.V., Oh, H.J., Lau, Y.F., Rauscher, F.J. 2009. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein which recruits the KAP1 co-repressor machinery. Journal of Biological Chemistry, 284(51): 35670-80. PMID: 19850934.

He, X., Kan, H., Cai, L., and Ma, Q. (2009) Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. J Mol Cell Cardiol 46(1), 47-58

Zhao, Z., He, X., Bi, Y., Xia, Y., Tao, N., Li Li, and Ma, Q. (2009) Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo, in human promyelocytic leukemic cells, and ex vivo in human blood neutrophils. Drug Metab and Dispos 37(2) 282-291

He, X. and Ma, Q. (2009) Induction of metallothionein 1 by arsenic via metal-activated transcription factor 1. Critical role of C-terminal cysteine residues in arsenic sensing. J Biol Chem 284(19) 12609-12621.

He, X. and Ma, Q. (2009) Nrf2 cysteine residues are critical for oxidant/electrophile-sensing, Keap1-dependent ubiquitination-proteasomal degradation, and transcription activation. Mol Pharmacol 76(6) 1265-1278

M.R. Miller and T.S. Miller "Bacterial contamination in rinse tanks". Undercurrent 24(6) p.12 – 13 (2009).

Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009 Sep 15;69(18):7198-206. Epub 2009 Sep 8.PMID: 19738060.

Ye JH, Rajendran VM. Adenosine: A critical immune-modulator in inflammatory bowel diseases - role of intestinal absorption. World J Gastroenterol 15:4491-4498, 2009.

Zhang M, and Riedel, H (2009) Insulin receptor kinase-independent signaling via tyrosine phosphorylation of phosphatase PHLPP1. J Cell Biochem, 107, 65-75

Jiang W, Deng W, Bailey SK, Nail CD, Frost AR, Brouillette WJ, Muccio DD, Grubbs CJ, Ruppert, JM, Lobo-Ruppert SM. Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid. Cancer Biol. Ther 2009 Feb 21;8(3): 287-96. PM: 19197145.

Lubet RA, Boring D, Steele VE, Ruppert, JM, Juliana MM, Grubbs CJ. Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis. Cancer Prev Res (Phila Pa). 2009 Feb;2(2):161-7. PM: 19196723.

Liu Z, Teng L, Bailey SK, Frost AR, Bland KI, LoBuglio AF, Ruppert JM, Lobo-Ruppert SM. Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling. Cancer Biol. Ther 2009; 8(19): 1840-51. PM: 19717984.

Kohan, A.B., Talukdar, I., Walsh, C.M., and Salati, L.M. (2009) A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids. Biochem.Biophys.Res.Comm., 388:117-121.

M.A. Chellaiah and M.D. Schaller. 2009. Activation of Src kinase by PTP-PEST in Osteoclasts- Comparative Analysis of the Effects of Bisphosphonate and Protein Tyrosine Phosphatase Inhibitor on Src Activation in vitro. J Cell. Physiol. 220:382-393.

S.M. Palmer, M.P. Playford, S.W. Craig, M.D. Schaller and S.L. Campbell. 2009. Lipid Binding to the Tail Domain of Vinculin: Specificity and the Role of the N and C termini. J Biol. Chem. 284:7223-7231.

Wonderlin, W.F. (2009) Constitutive, translation-independent opening of the protein-conducting channel in the endoplasmic reticulum. Pflugers Arch., 457:917-930.

Hogan TF, Yu JJ, Williams HJ, Altaha R, Liang XB and He Q. Oncocytic, Focally Anaplastic Thyroid Cancer Responding to Erlotinib. J Oncol Pharmacy Practice, 15(2): 111-117, 2009.

Hoeldtke R. D.and Van Dyke, K. Lipid peroxidation in early Type I diabetes mellitus is unassociated with oxidative damage to DNA. Metabolism 58, 731-734, 2009.

Zhou, X., Zhang, M. and Agazie, YM. Molecular Mechanism for SHP2 in Mediating HER2-Induced Signaling and Cell Transformation. J. Biol. Chem., in press.

Xueping Zhou, Michael R. Miller, Md Motaleb, Nyles W. Charon, Pingnian He. 2009. Spent culture medium from virulent Borrelia burgdorferi increases permeability of individually perfused microvessels of rat mesentery. Public Library of Science – One, in press.

M.A. Chellaiah and M.D. Schaller. 2009. Activation of Src kinase by PTP-PEST in Osteoclasts- Comparative Analysis of the Effects of Bisphosphonate and Protein Tyrosine Phosphatase Inhibitor on Src Activation in vitro. J Cell. Physiol., in press.

S.M. Palmer, M.P. Playford, S.W. Craig, M.D. Schaller and S.L. Campbell. 2009. Lipid Binding to the Tail Domain of Vinculin: Specificity and the Role of the N and C termini. J Biol. Chem. 284:7223-7231.

Wonderlin, W.F. 2009. Constitutive, translation-independent opening of the protein-conducting channel in the endoplasmic reticulum. Pflugers Arch. 457:917-930.

Yu JJ. 2009. Unlocking the Molecular Mechanisms of DNA Repair and Platinum Drug Resistance in Cancer Chemotherapy. Current Drug Therapy 4:19-28.

Yu JJ, Liang XB, Yan QW, Reed E, Fojo AT, Guo Y, He Q and Mueller MD. 2009. Chk2 and ERCC1 in the DNA Adduct Repair Pathway that Mediates Acquired Cisplatin Resistance. In:

Publications from 2008

Zhou, X. and Agazie, Y.M. 2008. Inhibition of SHP2 in Breast Cancer Cells Leads to Mesenchymal to Epithelial Transition and Induces Reversion to a Normal Mammary Epithelial Phenotype, Cell Death Differ 15:988-96.

Zhou, X., Coad, J., Ducatman, B. and Agazie, Y.M. 2008. The SHP2 Protein is Overexpressed in Breast Cancer Cell Lines and Infiltrating Ductal Carcinoma of the Breast, Implying its Involvement in Breast Cancer Development. Histopathology 53: 389-402.

Frisch, S.M. 2008. Caspase-8: Fly or Die. Cancer Res. 68: 4491-4493.

K. Sarma, R. Margueron, A. Ivanov, V. Pirotta and D. Reinberg. 2008. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol. Cell. Biol. 28:2718-31.

L. Zeng; K. L. Yap; A.V. Ivanov; X. Wang; S. Mujtaba; O. Plotnikova; F.J. Rauscher, III; M.-M. Zhou. 2008. Structural Insights into Human KAP1 PHD Finger-Bromodomain and Its Role in Gene Silencing. Nature Structural and Molecular Biology 15: 626-33.

Apopa, P. L., He, X., and Ma, Q. 2008. Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. J. Biochem. Mol. Toxicol. 22:63-76.

He, X., Chen, M.G., and Ma, Q. 2008. Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chem. Res. Toxicol. 21:1375-1383.

Zhao, Z., He, X., Bi, Y., Xia, Y., Tao, N., Li Li, and Ma, Q. 2008. Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo, in human promyelocytic leukemic cells, and ex vivo in human blood neutrophils. Drug Metabolism and Disposition in press. DMD Fast Forward. Online publication on November 24, 2008 as doi: 10.1124/dmd.108.023192.

He, X., Kan, H., Cai, L., and Ma, Q. 2008. Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. Journal of Molecular and Cellular Cardiology in press. Online publication on November 1, 2008 as doi:10.116/j.yjmcc. 2008.10.007.

Zhao, Z., Mao, Z., Bi, Y., Xia, Y., Tao, N., Li, L., He, X., and Ma, Q. 2008. Induction of CYP4F3 in white blood cells from benzene-poisoning patients and human HL60 cells. Proceedings of the 17th International Symposium on Microsomes and Drug Oxidations. Medimond S.r.l., Bologna, Italy, pp. 103-107.

He, X. and Ma, Q. 2008. Induction of metallothionein 1 by arsenic via metal-activated transcription factor 1. Critical role of the carboxyl cysteine thiol groups in arsenic sensing. J. Biol. Chem. Submitted

Ma, Q. and Lu, A.Y.H. 2008. The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. Current Drug Metabolism 9:374-383.

Ma, Q. 2008. Ah receptor: xenobiotic response meets inflammation. Blood 112:928-929.

Ma, Q. 2008. Xenobiotic-activated receptors: from transcription, to drug metabolism, to disease. Chem. Res. Toxicol. 21:1651-1671.

J.M. Rotchell, M.R. Miller, D.E. Hinton, R.T. Di Giulio, G.K. Ostrander. 2008. "Chemical carcinogenesis in fishes" in The Toxicology of Fishes, R.T. Di Biulio and D.E. Hinton, eds. P.531-644.

Rao AV, Younis IR, Sand GJ, Spasojevic I, Adams DJ, Decastro CM, Gockerman JP, Peterson BL, Petros WP, Moore JO, Rizzieri DA. 2008. Phase I evaluation of gemcitabine, mitoxantrone, and their effect on plasma disposition of fludarabine in patients with relapsed or refractory acute myeloid leukemia. Leuk Lymphoma 49:1523-1529.

Younis IR, Elliott M, Peer CJ, Cooper AJL, Pinto JT, Konat GW, Kraszpulski M, Petros WP, Callery PS. 2008. Dehydroalanine analog of glutathione: An electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1. J Pharmacol Exp Ther 327:770-776.

Armstrong AJ, Creel P, Turnbull J, Moore C, Jaffe TA, Haley S, Petros W, Yenser S, Gockerman JP, Sleep D, Hurwitz H, George DJ. 2008. A phase I-II study of docetaxel and atrasentan in men with castration-resistant metastatic prostate cancer. Clin Cancer Res 14:6270-6276.

Beasley GM, Petersen RP, Yoo J, McMahon N, Aloia T, Petros W, Sanders G, Cheng TY, Pruitt SK, Seigler H, Tyler DS. 2008. Isolated Limb Infusion for In-Transit Malignant Melanoma of the Extremity: A Well-Tolerated but Less Effective Alternative to Hyperthermic Isolated Limb Perfusion. Ann Surg Oncol 15:2195-2205.

Cooper AJL, Younis IR, Niatsetskaya ZV, Krasnikov BF, Pinto JT, Petros WP, Callery PS. 2008. Metabolism of the cysteine S-conjugate of busulfan involves a ß-lyase reaction. Drug Metabol Dispos 36:1546-52.

Younis IR, Malone S, Friedman HS, Schaaf LJ, Petros WP. Enterohepatic recirculation model of irinotecan (CPT-11) & metabolite pharmacokinetics in patients with glioma. Cancer Chemother Pharmacol., in press.

Czito BG, Cohen DP, Kelsey CR, Lockhart AC, Bendell JC, Willett CG, Petros WP, D'Amico TA, Truax R, Hurwitz HI. 2008. A Phase I Study of UFT/Leucovorin, Carboplatin, and Paclitaxel in Combination with External Beam Radiation Therapy for Advanced Esophageal Carcinoma. Int J Radiat Oncol Biol Phys 70:1066-1072.

Plotnikova OV, Golemis E.A and Pugacheva.E.N. 2008. Cell cycle-dependent ciliogenesis and cancer. Cancer Res. 68:2058-61.

Hendrickson A, Bumstead K, Natoli R, Ramamurthy V, Possin D, Dijajadi H and Provis J. 2008. Rod photoreceptor differentiation in fetal and infant human retina. Exp Eye Res. 87:415-26.

Zhang M, Deng, Y, Tandon R, Bai C, and Riedel, H. 2008. Essential role of PSM/SH2B1 variants in insulin receptor catalytic activation and the resulting cellular responses. J. Cell. Biochem. 103:162-181.

Zhang M, Deng, Y, and Riedel, H. 2008. PSM/SH2B1 splice variants: critical role in Src catalytic activation and the resulting STAT3-mediated mitogenic response. J. Cell. Biochem. 104:105-118.

Deng, Y, Zhang M, and Riedel, H. 2008. Mitogenic roles of Gab1 and Grb10 as a direct cellular partners in the regulation of MAP kinase signaling. J. Cell. Biochem. 105:1172-1182.

Jiang, W, Lobo-Ruppert, SM, and Ruppert, JM. 2008. Bad things happen in the basal layer: KLF4 and squamous cell carcinoma. Cancer Biology and Therapy 7:783-5.

Jiang W, Deng W, Bailey SK, Nail CN, Frost, AR, Brouillette, WJ, Muccio, DD, Grubbs, CJ, Ruppert, JM, and Lobo-Ruppert, SM. 2008. Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid. Cancer Biology and Therapy, in press.

S.M. Palmer, M.D. Schaller and S.L. Campbell. 2008. Vinculin Tail Conformation and Self Association is Independent of pH and H906 Protonation. Biochemistry, 47:12467-12475.

M.P. Playford, K. Vadali, X. Cai, K. Burridge and M.D. Schaller. 2008. Focal Adhesion Kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho. Experimental Cell Research, 314:3187-3194.

D.M. Scheswohl, J.R. Harrell, Z. Rajfur, G. Gao, S.L. Campbell, M.D. Schaller. 2008. Multiple Paxillin Binding Sites Regulate FAK Function. J. Mol. Signaling 3:1.

X. Cai, D. Lietha, D.F. Ceccarelli, A.V. Karginov, Z. Rajfur, K. Jacobson, K.M. Hahn, M.J. Eck, M.D. Schaller. 2008. Spatial and Temporal Regulation of FAK Activity in Living Cells. Mol. Cell. Biol. 28:201-214.

M.D. Schaller. 2008. Calcium-Dependent Pyk2 Activation: A Role for Calmodulin? Biochemical Journal 410:e3-4.

Hogan T, Yu JJ, Williams HJ, Altaha R, Liang XB and He Q. 2008. Refractory Oncocytic (Hürthle Cell) Thyroid Cancer Response to Erlotinib Human Pathology. J Oncol Pharmacy Practice in press.

Publications from 2007

Yu JJ and Flynn DC. 2007. EGFR Artifactual Mutations Associated with two DNA Sequencers. BioTechniques 42:41.

Senft, J., Helfer, B. and Frisch, S.M. 2007. Caspase-8 interacts with the p85 subunit of phosphatidylinositol-3-kinase to regulate cell motility, adhesion and Rac activation. Cancer Res. 67: 11505-11509.

Huang, X.D., Masselli, A., Frisch, S.M., Hunton, I., Jiang, Y., Wang, J.Y.J. 2007. Blockade of TNF-induced Bid cleavage by caspase-resistant Rb. J. Biol. Chem. 282: 29401-13.

Talukdar, S., Bhatnagar, S., Dridi, S., and Hillgartner, F. B. 2007. Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-α transcription by the liver X receptor agonist T0-901317. J. Lipid. Res. 48:2647-2663.

S. Dadke, S. Cotteret, S-C. Yip, Z. M. Jaffer, F. Haj, A. Ivanov, F. J. Rauscher, III, K. Shuai, T. Ng, B. G. Neel, and J. Chernoff. 2007. Regulation of Protein Tyrosine Phosphatase (PTP) 1B by sumoylation. Nature Cell Biol. 9:80-85.

D. White, D. Negorev, H. Peng, A. Ivanov, G. Maul, and F. Rauscher 3rd. 2007. KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res. 66: 11594-9.

G. Ivanov, T. Ivanova, J. Kurash, A. Ivanov, S. Chuikov, F. Gizatullin, E. Herrera-Medina, F. Rauscher III, D. Reinberg, and N. Barlev. 2007. Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage. Mol. Cell. Biol. 27:6756-69.

A. Ivanov, H. Peng, V. Yurchenko, D. Negorev, W. Fredericks, G. Maul, M. Sadofsky, M.-M. Zhou, F. Rauscher III. 2007. PHD Domain-mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromo Domain which is Required for Gene Silencing. Molecular Cell 28: 823-37.

He, X., Lin, G. X., Chen, M. G., Zhang, J. and Ma, Q. 2007. Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association. Toxicol Sci 98:298-309.

Hubbs, A. F., Benkovic, S., Miller, D., O'Callaghan, J., Battelli, L. A., Schwegler-Berry, D. and Ma, Q. 2007. Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2. American Journal of Pathology 170:2068-2076.

Ma, Q. and Lu, A. Y. H. 2007. CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies. Drug Metabolism and Disposition 35:1009-1016.

Ma, Q. 2007. ADPF and agonist-induced down-regulation of Ah receptor: controlling xenobiotic response by receptor degradation. Molecular Interventions 7:133-137.

Howell, DM, Morgan, WJ, Jarjour, AA, Spirou, GA, Berrebi, AS, Kennedy, TE, and Mathers, PH. 2007. Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus. J. Comp. Neurol. 504:533-549.

R. G. Bakker, C. LI, M.R. Miller, C. Cunningham, and N. W. Charon. 2007. Identification of specific chemoattractants and complementation of cheA2 of Borrelia burgdorferi: A flow cytometry-based capillary tube chemotaxis assay. Applied Env. Microbiol. 73:1180-1188.

Md. A. Motaleb, M.R. Miller, R. G. Bakker, C. Li and N. Charon. 2007. Isolation and Characterization of Chemotaxis Mutants of the Lyme Disease Spirochete Borrelia burgdorferi Using Allelic Exchange Mutagenesis, Flow Cytometry and Cell Tracking. Methods in Enzymology 422:421-437.

Md. A. Motaleb, M.R. Miller, C. Li and N. W. Charon. 2007. Phosphorylation assays of chemotaxis two-component system proteins in Borrelia burgdorferi. Methods in Enzymology 422:438 – 447.

A.M. Magro, A.D. Magro, C. Cunningham and M.R. Miller. 2007. Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cells. Neoplasma 54:517 - 526.

M.R. Miller and Md. Motaleb. 2007. Scuba divers rinse tanks harbor many microorganisms. Microbe 12:577.

Hurwitz HL, Cohen RB, McGovern JP, Hirawat S, Petros WP, Natsumeda Y, Yoshinari T. 2007. A phase I study of the safety and pharmacokinetics of edotecarin (J-107088), a novel topoisomerase I inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol 59:139-147.

Pugacheva EN, Jablonski SA, Hartman TR, Henske EP and Golemis EA. 2007. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129:1351-63.

Riedel H. 2007. Models for tumor growth and differentiation. In The Cancer Handbook Vol. 2. 4: Pre-clinical models for human cancer (ed Alison MA), 954-969 Nature Publishing Group, London.

Li, X, Deng, W, Lobo-Ruppert, SM, and Ruppert, JM. 2007. Gli1 acts through Snail and E-cadherin to promote nuclear signaling by -catenin. Oncogene 26: 4489-4498.

M.A. Zayed, W. Yuan, T.M. Leisner, D. Chalothorn, A.W. McFadden, M.D. Schaller, M.E. Hartnett, J.E. Faber, and L.V. Parise. 2007. CIB1 Regulates Endothelial Cells and Ischemia-Induced Pathological and Adaptive Angiogenesis. Circulation Research 101:1185-1193.

D. Lietha, X. Cai, Y. Li, M.D. Schaller, and M.J. Eck. 2007. Structure and regulation of Focal Adhesion Kinase. Cell 129:1177-1187.

K. Vadali, X. Cai and M.D. Schaller. 2007. Focal Adhesion Kinase: An Essential Kinase in the Regulation of Cardiovascular Functions. IUBMB Life 59:709-716.

Boesze-Battaglia K, Song H, Sokolov M, Pankoski-Walker L, Gretzula C, Gallagher B, Rachel RA, Jenkins NA, Copeland NG, Morris F, Yeagle P, Williams D, Lillo C, Damek-Poprawa M. 2007. The tetraspanin protein, periferin-2 complexes with melanoregulin, a putative membrane fusion regulator. Biochemistry 46:1256-1272.

Lobanova ES, Finkelstein S, Song H, Tsang SH, Chen CH, Sokolov M, Skiba NP, Arshavsky VY. 2007. Translocation of transducin in rod is triggered by saturation of the GTPase activating complex. J. Neurosci. 27:1151-1160.

Song JH, Song H, Wensel TG, Sokolov M, Martemyanov KA. 2007. Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol. Cell. Neurosci. 35:311-319.

Song H, Belcastro M, Young EJ, Sokolov M. 2007. Compartment-specific phosphorylation of phosducin in rod underlies adaptation to various levels of illumination. J. Biol. Chem. 282:23613-2362.

Krispel CM, Sokolov M, Chen YM, Song H, Herrmann R, Arshavsky VY, Burns ME. 2007. Phosducin regulates the expression of transducin βγ subunits in rod photoreceptors and does not contribute to phototransduction adaptation. J. Gen. Physiol. 130:303-312.