Vazhaikkurichi M. Rajendran, Ph.D.
Professor
BS: University of Madras
PhD: University of Madras
Postdoctoral Training: Medical College of Wisconsin
Joined the faculty: WVU: 2006, Biochemistry: 2009
Teaching: MICB 796
Office: 3151 HSN
Phone: (304) 293-0150
Fax: (304) 293-6846
E-mail: vrajendran@hsc.wvu.edu
Research Interests:
Our laboratory is interested in investigating the electrolyte transport processes that regulate colonic fluid movement during physiological and pathophysiological (diarrhea and ulcerative colitis) conditions. We focus to identify the Ca2+-activated intermediate conductance (also known as KCNN4) K+ channel isoform that provides the driving force for Cl- secretion in several fluid secreting epithelial cells. To achieve this goal, we employ electrophysiology, biochemical, molecular and biophysical techniques.
Lab Website:
Rajendran Lab
References:
Nanda Kumar NS, Singh SK, Rajendran VM. K+ Secretion mediated via mucosal KCNN4 Channels drives electrogenic Cl- secretion in rat colon (submitted)
Barmeyer C, Rahner C, Yang Y, Sigworth FJ, Binder HJ, Rajendran VM. Cloning and identification of tissue specific expression of KCNN4 splice variants in rat colon. Am J Physiology Cell Physiology (In Press).
Singh SK, O'Hara B, Talukder JR, Rajendran VM. Aldosterone induces active K+ secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon. Am J Physiol Cell Physiol. 2012 Feb 8. [Epub ahead of print]
Basalingappa KM, Rajendran V.M., Wonderlin W.F. Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G905-11. Epub 2011 Aug 25.
Nanda Kumar NS, Singh SK, Rajendran VM. K+ Secretion mediated via mucosal KCNN4 Channels drives electrogenic Cl- secretion in rat colon (submitted)
Barmeyer C, Rahner C, Yang Y, Sigworth FJ, Binder HJ, Rajendran VM. Cloning and identification of tissue specific expression of KCNN4 splice variants in rat colon. Am J Physiology Cell Physiology (In Press).
Sendhil Velan S, Said N Durst C, Spencer R, Frisbee S, Frisbee J, Raylman R, Albert Thomas M, Rajendran VM, Always S. Distinct patterns of fat metabolism in skeletal muscle of normal weight, overweight, and obese humans. Am J Physiol - Regulatory, Integrative and Comparative Physiology 295:R1060-R1065, 2008.
Sandeep, S., Rajendran VM, Ramakrishna BS and Binder HJ. Butyrate stimulates apical Na-H exchange activity and NHE3 protein expression in presence of cholera toxin. Am J Physiol Gastrointest Liver Physiol 293:G857-63, 2007.
Jiang Z, Asplin JA, Evan AP, Rajendran VM, Velazquez H, Nottoli TP, Binder HJ, and Aronson PS. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet 38: 474-478, 2006.
Joiner WJ, Basavappa S, Vidyasagar S, Nehrke K, Krishnan S, Binder HJ, Boulpaep EL, Rajendran VM. Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon. Am J Physiol Gastrointest Liver Physiol 285: G185-G196, 2003.