- Patient or Population: Patients who die from Methadone-related complications
- Intervention or Indicator: Understanding physiological mechanisms of Methadone
- Comparison or Control: Past lack of knowledge of mechanisms of Methadone
- Outcome: Increased safety by understanding the uses and properties of using Methadone
5: Hum Psychopharmacol. 2004 Dec;19(8):565-76.
The effects of methadone and its role in fatalities.
Corkery JM, Schifano F, Ghodse AH, Oyefeso A.
National Programme on Substance Abuse Deaths, Department of Mental Health-Addictive Behaviour, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. email@example.com
Methadone is a synthetic opioid, used both as an analgesic in severe pain relief and now mainly in the treatment of opiate dependence. Such use of the drug has increased as its advantages have become widely recognized. There are undesirable outcomes from its greater use, including a substantial market in diverted methadone and a high number of deaths where the drug has been implicated. It is important to understand how and why methadone causes death so that such fatalities can be minimized, and to disseminate such information. This paper presents an overview of the chief effects of methadone on the human body, considering its metabolism, drug interactions and tolerance. The principal mechanisms by which methadone causes death are discussed: respiratory depression, aspiration of vomit, pulmonary oedema, bronchopneumonia, cardiac problems and renal failure. Many such deaths are preventable, if drug interactions and polydrug use are avoided, its longer period of metabolism and individuals' tolerance levels are considered. It is hoped that this paper will (a) help guide health professionals in their management and treatment of patients participating in methadone treatment programmes, and (b) provide some basic information for those dealing with individuals who have consumed methadone. 2004 John Wiley & Sons, Ltd.
PMID: 15378662 [PubMed - indexed for MEDLINE]