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Stephen E Alway PhD, FACSM

Professor, Chair of Exercise Physiology

8320 HSS
Morgantown, WV 26506
salway@hsc.wvu.edu
P: 304-293-0772
F: 304-293-7105

Professor, Chair of Exercise Physiology

Human Performance - Exercise Physiology (SOM)
Admin

Joint Professor of Physiology and Pharmacology

Physiology & Pharmacology (SOM)
Faculty

Education

Medical Sciences-Neuroscience, McMaster University. Hamilton, Ontario, Canada L8N 3Z5 Ph.D. , PhD, 1985
Physiology, McMaster University, Hamilton, Ontario, Canada L8S 4K1, MS, 1981
Kinesiology (Honors BS), University of Waterloo, Waterloo, Kinesiology, Ontario, BS, 1978

Details


Long Bio

Biosketch: Click Here

Academic Positions:
    • 07-2005 to present - Professor and Chair (tenured), Division of Exercise Physiology, Department of Human Performance and Exercise Science, School of Medicine, West Virginia University, Robert C. Byrd Health Science Center, Morgantown, WV 26506-9277. (Effective 07-01-05)
    • 07-2005 to present - Joint Professor, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Robert C. Byrd Health Science Center, Morgantown, WV (effective 07-01-05)
    • 07-2007 to 01-2008 - Interim Director of Graduate Studies, Exercise Physiology, West Virginia University School of Medicine.
    • 06-2002 to 07-2005- Adjunct Associate Professor, Department of Physiology and Pharmacology, West Virginia University School of Medicine, Robert C. Byrd Health Science Center, Morgantown, WV
    • 01-2000 to 12-2005 - Associate Professor and Director of Graduate Studies, Division of Exercise Physiology, Department of Human Performance and Exercise Science, School of Medicine, West Virginia University, Robert C. Byrd Health Science Center, Morgantown, WV 26506-9277.
    • 12-95 to 01-2000 - Associate member, H. Lee Moffit Cancer Center & Research Institute, Member of the Molecular Oncology Research Group, University of South Florida, Tampa, FL 33612
    • 12-96 to 01-2000 - Member of the Molecular Oncology Research Group, H. Lee Moffit Cancer Center & Research Institute University of South Florida, Tampa, FL 33612
    • 12-95 to 01-2000 - Associate Professor, Aging Studies Ph.D. Program, College of Arts and Sciences, Department of Gerontology University of South Florida, Tampa, FL 33612
    • 07-95 to 01-2000 - Faculty Member, Institute on Aging University of South Florida, Tampa, FL 33612.
    • 07-95 to 01-2000 - Associate Professor and Graduate Coordinator, Department of Anatomy, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa FL 33612-4799.
    • 07-95 to 01-1998 - Adjunct Associate Professor, Graduate III status, Department of Exercise and Sport Sciences, The Ohio State University, 337 West, 17th Avenue, Columbus, OH 43210-1284
    • 10-93 to 06-95 - Associate Professor, Graduate III status, (Tenured 7-93), Section of Exercise Physiology, School of Health, Physical Education and Recreation, The Ohio State University, 337 West, 17th Avenue, Columbus, OH 43210-1284
    • 06-90 to 09-93 - Assistant Professor, Graduate III status, Section of Exercise Physiology, School of Health, Physical Education and Recreation, The Ohio State University, 337 West, 17th Avenue, Columbus, OH 43210-1284
    • 06-90 to 06-95- Director, Neuromuscular Laboratory, Departments of Exercise Physiology and Veterinary Physiology, 1900 Coffey Road, The Ohio State University, and Muscle Function Laboratory, Dept. of Exercise Physiology, 337 West 17th Ave. Columbus, OH 43210-1284
    • 06-89 to 05-90 - Assistant Professor, tenure tract, Department of Anatomy, Cell Biology and Neuroscience, Oral Roberts University, School of Medicine, South Lewis Ave. Tulsa, OK
    • 09-86 to 05-89 - Instructor, Department of Cell Biology and Neuroscience
    • University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235
    • 09-86 to 05-89 - Assistant Professor (Secondary appointment, non-tenure track) Human Performance Center University of Texas Southwestern Medical Center at Dallas / ST. Paul's Hospital., Dallas, TX 75235

Publications

Selected References:

 Apoptosis

  • ALWAY SE., Pereira SL, Edens NK, Hao Y and Bennett BT. β-Hydroxy-β-methylbutyrate (HMB) enhances the proliferation of satellite cells in fast muscles of aged rats during recovery from disuse atrophy, Exp. Gerontol. 48(9):973-984, 2013. PMID: 23832076
  • Y. Wang, J.S. Mohamed, and S.E. ALWAY. Myogenic differentiation is modulated by M-cadherin-induced phosphorylation of β-catenin. Cell and Tissue Research 351(1):183-200, 2013. PMCID: PMC3558526
  • Bryner, R. W., M. Woodworth-Hobbs, D.L. Williamson and S.E. ALWAY. Docosahexaenoic acid (DHA) protects muscle cells from palmitate-induced atrophy. ISRN Obesity, vol. 2012, Article ID 647348, 14 pages, 2012. doi:10.5402/2012/647348.
  • Durbin, S.M., J.R. Jackson, M. J Ryan, J.C. Gigliotti, S.E. ALWAY and, J.C. Tou. Resveratrol Supplementation Influences Bone Properties in the Tibia of Hindlimb Suspended Mature Fisher 344 x Brown Norway Male Rats. Applied Physiology, Nutrition, and Metabolism. 37 (6):1179-1188, 2012. PMID:23050779
  • ALWAY, S.E., Cutlip, R.G. Resistance loading and signaling assays for oxidative stress in rodent skeletal muscle. Methods in Molecular Biology 798:185-211, 2012. PMID:22130838
  • ALWAY, S.E., M.R. Morissette and P.M. Siu. Chapter 4, Aging and apoptosis in muscle. Handbook of the Biology of Aging. Edward J. Masoro and Steven Austad (Editors) Elsevier. 7th Edition. 2011, pp. 64-139. ISBN-10: 012378638X, ISBN-13: 978-0123786388
  • Wang, Y., Y. Hao and S.E. ALWAY.  Suppression of Glycogen Synthase Kinase 3 beta (GSK-3ß) Activation by M-cadherin protects C2C12 Myoblasts against mitochondrial-associated Apoptosis during Myogenic Differentiation. J. Cell Science. 124(22):3835-47, 2011.
  • Quadrilatero, J., S.E. ALWAY and E. Dupont-Versteegden. Skeletal Muscle Apoptotic Response to Physical Activity: Potential Mechanisms for Protection. Appl. Physiol. Met. Nutr. 36(5):608-17, 2011. 
  • ALWAY, S.E. Chapter 10. Apoptosis in Skeletal Muscle Health and Conditions of Muscle Wasting. In: Modern Insights into Disease from Molecules to Man: APOPTOSIS, Victor R. Preedy (Editor.): Science Publishers, CRC. 2010 pp 167-182. ISBN: 1578085837
  • Hao, Y.,  J.R. Jackson, Y. Wang, N. Edens, S.L. Pereira, and S.E. ALWAY.  β-Hydroxy-β-methylbutyrate reduces muscle mass loss and myonuclear apoptosis following hindlimb suspension and reloading in aged rats.  Am J Physiol Regul Integr Comp Physiol. 301(3):R701-R715,  2011. PMID: 21697520
  • ALWAY, S.E. and P.M. Siu Nuclear apoptosis and sarcopenia. Sarcopenia-Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments. G. Lynch, editor. Springer, pp. 173-206
  • Williamson CL, Dabkowski ER, Baseler WA, Croston TL, ALWAY, S.E and Hollander JM. Enhanced Apoptotic Propensity in Diabetic Cardiac Mitochondria: Influence of Subcellular Spatial Location. Am J Physiol Heart Circ Physiol 298(2): H633-H642, 2010
  • ALWAY, S.E. and M.R. Morissette. Chapter 4,   Apoptosis in aging muscle. Handbook of Aging.  E. J. Masoro and Steven Austad (Editors) Elsevier. 7th Edition. 2011, pp. 64-139.
  • Butler, D.C.,  S. Haramizu, D.L. Williamson and S.E. ALWAY. Phospho-ablated Id2 is growth suppressive and pro-apoptotic in proliferating myoblasts. PLoS One, July 2009 | Volume 4 | Issue 7 | e6302-e6302, 2009.
  • Siu, P.M, and S.E. ALWAY. Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss. Front Biosci, 14:432-452, 2009.
  • Peterson JM, Wang Y, Bryner R, Williamson DL and ALWAY,  SE.  Bax signaling mediates palmitate-induced apoptosis in C2C12 myotubes. Am J Physiol Endocrinol Metab: 295:E1307-E1314, 2008.
  • Peterson JM, Bryner RW, Sindler A, Frisbee JC and ALWAY,  SE. Mitochondria apoptotic signaling is elevated in cardiac but not skeletal muscle in the obese Zucker rat and is reduced with aerobic exercise. J Appl Physiol  105:1934-1943, 2008.
  • Pistilli EE and S.E. ALWAY. Systemic elevation of interleukin-15 in vivo promotes apoptosis in skeletal muscles of young adult and aged rats. Biochem Biophys Res Commun 373:20-24, 2008.
  • Siu, P.M., and S.E. ALWAY. Denervation-induced apoptosis and oxidative stress in skeletal muscle Front. Biosci. Free Radicals in Biology and Medicine, 2008: Chapter 9 pp 1-31, 2008  ISBN: 978-81-308-0267-1.
  • ALWAY, S.E., and P.M. Siu. Nuclear apoptosis contributes to sarcopenia. Exerc. Sport Sci. Rev., Vol. 36, No. 2, pp. 51-57, 2008
  • ALWAY, S.E "Pathways of Apoptosis in Muscle", in Hood, D. (ed.), Mitochondrial Biogenesis: Processes, Regulation, Functions and Disease, 2007. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London  (online at http://www.hstalks.com/?t=BL0151480-Alway)
  • ALWAY, S.E "Pathways of Apoptosis in Muscle", in Hood, D. (ed.), Mitochondrial Biogenesis: Processes, Regulation, Functions and Disease, 2007. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.
  • Degens, H., A.K. Swisher, Y.F. Heijdra, P.M. Siu, P. N. R. Dekhuijzen S.E. ALWAY. Apoptosis and Id2 expression in diaphragm and soleus muscle from the emphysematous hamster. Am. J. Physiol: Cell Physiol.  293:R135-R144, 2007.
  • Pistilli, E.E., Siu, P.M., and S.E. ALWAY. Responses of interleukin-15 to aging and skeletal muscle unloading-induced apoptosis in rats and quails. Am. J. Physiol: Cell Physiol.  292 (4):C1298-C1304, 2007.
  • Smith CA, F.D. Stauber, C.L. Waters CL, S.E. ALWAY and WT Stauber. Transforming growth factor-β following skeletal muscle strain injury in rats. J Appl Physiol  102 (2):755-761, 2007.
 

Oxidative Stress in Muscle

  • ALWAY, S.E., Cutlip, R.G. Resistance loading and signaling assays for oxidative stress in rodent skeletal muscle. Methods in Molecular Biology 798:185-211, 2012. PMID:22130838
  • Ryan MJ, Jackson JR, Hao Y, Leonard SS and ALWAY SE. Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice. Free Radic Biol Med  51 (1):38-52, 2011. PMID: 21530649
  • J.R. Jackson, M.J. Ryan, and S.E. ALWAY.  Long-Term Supplementation with Resveratrol Alleviates Oxidative Stress, but does not Attenuate Sarcopenia in Aged Mice.  J. Gerontol: Biological Sciences  66 (7):751-764, 2011.  PMID: 21454355
  • Jackson, J.R., M.J. Ryan, Y. Hao, S.E. ALWAY. Mediation of Antioxidant Capacity and Apoptotic Signaling by Resveratrol Following Muscle Disuse in the Gastrocnemius Muscles of Young and Old Rats"   Am J Physiol Regul Integr Comp Physiol.  299 (6): R1572-R1581, 2010.
  • Ryan, M.J. H.J. Dudash, M. Docherty, K.B. Geronilla, B.A. Baker, G.G. Haff, R.G. Cutlip, and S.E. ALWAY. Vitamin E and C supplementation reduces oxidative stress and improves antioxidant enzymes and positive muscle work in chronically loaded dorsiflexor muscles of aged rats. Exp Gerontol  45: 882-895, 2010.
  • Ryan MJ, Jackson JR, Hao Y, Williamson, C., Hollander JM and ALWAY, S.E. Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged rats. J Gerontol A Biol Sci Med Sci 65:815-831, 2010.
  • Siu, P.M, Y, Wang, and S.E. ALWAY. Caspase-independent and caspase-dependent apoptotic signaling coordinate apoptosis induced by H2O2-mediated oxidative stress in differentiated C2C12 myotubes  Life Sci. Res.  84:468-481,2009.
  • Siu PM, Pistilli EE, ALWAY SE. Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading. J Appl Physiol :105:1695-1705, 2008.
  • Ryan MJ, Dudash HJ, Docherty M, Geronilla KB, Baker BA, Cutlip RG, and S.E. ALWAY. Aging-dependent regulation of antioxidant enzymes and redox status in chronically loaded rat dorsiflexor muscles . J Gerontol A Biol Sci Med Sci 63: 1015-1026, 2008.
  • Siu, P.M., and S.E. ALWAY. Denervation-induced apoptosis and oxidative stress in skeletal muscle Front. Biosci. Free Radicals in Biology and Medicine, 2008: Chapter 9 pp 1-31, 2008  ISBN: 978-81-308-0267-1.
Muscle adaptations and metabolism
  • Y. Wang, J.S. Mohamed, and S.E. ALWAY. Myogenic differentiation is modulated by M-cadherin-induced phosphorylation of β-catenin. Cell and Tissue Research 351(1):183-200, 2013. PMCID: PMC3558526
  • Bryner, R. W., M. Woodworth-Hobbs, D.L. Williamson and S.E. ALWAY. Docosahexaenoic acid (DHA) protects muscle cells from palmitate-induced atrophy. ISRN Obesity, vol. 2012, Article ID 647348, 14 pages, 2012. doi:10.5402/2012/647348
  • ALWAY, S.E. and P.M. Siu Nuclear apoptosis and sarcopenia. In Sarcopenia-Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments. G. Lynch, editor. Springer, 2011, pp. 173-206.
  • Wang Y, Mohamed JS, Alway SE. M-cadherin-inhibited phosphorylation of b-catenin augments differentiation of mouse myoblasts. J. Cell Science 124 (22):3835-3847, 2011. PMID:22114306, PMCID:PMC3225270
  • Sharif S, Thomas JM, Donley DA, Gilleland DL, Bonner DE, McCrory JL, Hornsby WG, Zhao H, Lively MW, Hornsby JA and Alway SE. Resistance exercise reduces skeletal muscle cachexia and improves muscle function in rheumatoid arthritis. Case Report Medicine 2011:205691, 2011.
  • Drake, J., ALWAY, S.E and Hollander JM. Williamson and D.L. Williamson.  AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol.  299 (6):R1546-R1554, 2010
  • Williamson DL, Butler DC and ALWAY SE. AMPK inhibits myoblast differentiation through a PGC-1α -dependent mechanism. Am J Physiol Endocrinol Metab 297(2):E304-E314,2009.
  • Siu PM, Pistilli EE, ALWAY SE. Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading. J Appl Physiol :105:1695-1705, 2008.
  • Peterson JM, Bryner R and S.E. ALWAY. Satellite cell proliferation is reduced in muscles of obese Zucker rats, but restored with loading. Am J Physiol Cell Physiol  295:C521-C528, 2008.
  • Peterson JM, Bryner R, J.C. Frisbee sand S.E. ALWAY. Effects of Exercise and Obesity on UCP3. Content in Rat Hindlimb Muscles. Med. Sci. Sports Exerc. 40 (9) 1616–1622, 2008.
  • Velan, S.S., R. Raylman, J.C. Frisbee, R. Spencer and S.E. ALWAY. Distinct Patterns of Fat Metabolism in Skeletal Muscle of Normal Weight, Overweight, and Obese Humans. Am J Physiol Regul Integr Comp Physiol.  295: R1060-R1065, 2008.
  • Smith CA, F.D. Stauber, C.L. Waters CL, S.E. ALWAY and WT Stauber. Transforming growth factor-ß following skeletal muscle strain injury in rats. J Appl Physiol  102 (2):755-761, 2007.

 

Awards

Academic Awards and Honors

  • 1981 Yates Scholarship, McMaster University
  • 1982 Ontario Graduate Scholarship, McMaster University
  • 1985 Graduate Student Achievement Award and Stipend, Canadian Association of Sports Sciences
  • 1986 Ontario Gerontology Fellow, University of Waterloo
  • 1991 American College of Sports Medicine Fellow,
  • 1992 American Federation for Aging Research Award for Biomedical Research
  • 2000 Sports Scientist of the Year 2000, In recognition for over 10 years of contributions to the field of Exercise and Sport Science, (National Strength and Conditioning Association)

Review boards and other honors

  • 2013    Member Scientific Review Committee Cellular and Molecular Medicine/2013/08 CAMM 1 (6/3/2013)
  • 2013    Natural Sciences and Engineering Research Council of Canada, Discovery Grant review Committee (4/24/2013)
  • 2013    Special Emphasis Panel/Scientific Review Group, NIAMS 2013/08 ZAR1 -KM -(M1) (4/15/2013)
  • 2013    American Federation for Aging Research, Grant review committee (02/2013)
  • 2012    Special Emphasis Panel/Scientific Review Group, Cellular and Molecular Medicine/CAMM: (11/19/2012)
  • 2012    Special Emphasis Panel/Scientific Review Group, National Institute on Aging: Skeletal muscle ZAG1 ZIJ-9 JI (10/23/2012)
  • 2012    Study section member: SMEP (Skeletal Muscle and Exercise Physiology) 2013/01 (10/04-6, 2012)
  • 2012    Scientific Review Committee, Special Emphasis Panel/Scientific Review Group 2012/05 ZRG1 MOSS-T (90) S (02/07-08/2012)
  • 2011     Member, National Institute of Arthritis and Musculoskeletal and Skin Diseases Special Emphasis Panel ZRG1 MOSS-C(90) (09/28/2011)
  • 2011     Member Special Emphasis Review Committee: Ancillary Studies RFA’s (AR-11-013 (R01) and AR-11-012 (R21). (NIAMS/NIH) (02/2011)
  • 2011     Member, Special Emphasis Panel ZRG1 MOSS C(03) (01/24-25/2011)
  • 2010     Natural Sciences and Engineering Research Council of Canada NSERC-EG-1502 Review of Discovery Grant Applications (grant review member) (11/2010)
  • 2010     Member, Scientific Review Committee, Special Emphasis, ZAR1 KM (M1) 1 - Loan Repayment Program Review (4/30/2010)
  • 2010     Member Scientific Review Committee (Adhoc member). Muscular Dystrophy Association. (3/2010)
  • 2009     Member, Scientific Review Committee, AREA grant Panel 11.  ZRG 1 MOSS G52R Special Emphasis Panel (12/07/2009)
  • 2009     Member, Scientific Review Committee, Special Emphasis Panel 2010/01 ZAR1 CHW-F (M2) Ancillary Clinical Studies (11/012/2009)
  • 2009    Chair, Scientific Review Committee, Special Emphasis Panel, ZAG1 ZIJ-5-01, Muscle Growth and Regeneration in Aging (NIH/NIA) (07/31/09)
  • 2009     Member, Scientific Review Committee, Special Emphasis Panel, Load Repayment Program  ZAR1 KM-D M1 1 (NIH/NIAMS) (04/30/09)
  • 2009     Member Scientific Review Committee Cellular Mechanisms of Aging and Development (CMAD Study Section; (02/5/09- 02/6/09);
  • 2009     2009/08 ZAR1 KM-D (M1) 1 Loan Repayment Program Review (04/30/2009-04/30/2009)
  • 2008     Member Scientific Review Committee Cellular Mechanisms of Aging and Development (CMAD Study Section (10/6/08- 10/7/08)
  • 2008    Member Scientific Review Committee Cellular Mechanisms of Aging and Development (CMAD Study Section (2/5/08- 2/6/08)
Editorial board

  • 2013-present, Associate Editor, PLOS ONE
  • 2013-present, Editorial Board Member, BioMed Research International
  • 2013-present, Editorial Board Member, International Journal of Applied Exercise Physiology (IJAE)
  • 2012-present, Editorial Board Member, ISRN Biochemistry
  • 2008-present, Editorial Board Member, American Journal of Physiology: Regul. Integ.Comp. Physiol.
  • 2005-present, Associate Editor, Exercise Sports Science Reviews
  • 1992-present, Associate Editor, Journal of Strength and Conditioning Research

CV

Current CV

Research


Research Statement

Post-doctoral Research Experience:

  • 09-86 to 05-89 Instructor, Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235
  • 1984-1985 Research Assistant, Department of Kinesiology, University of Waterloo, Waterloo, Ontario Canada

Research Interests:
Our laboratory studies muscle loss due to aging and disuse in heart and skeletal muscle and seeks to find strategies to prevent or reduce this muscle wasting. Loss of skeletal muscle with aging is called sarcopenia, which is characterized as an age-associated loss of muscle fiber size and muscle fiber number with aging. This loss of muscle tissue results in decreased muscle strength and a loss of independence, and this is a major problem in the elderly population. Our laboratory uses models of hypertrophy and atrophy to study the neural dependent and neural independent cellular and molecular mechanisms leading muscle growth and muscle atrophy in aging muscles. We are particularly interested in the process of apoptosis that occurs in muscle stem cells (satellite cells) and myonuclei and identifying strategies to reduce apoptotic signaling and improving muscle growth and regeneration in aging and diabetes.

Loss of skeletal muscle also accompanies heart pathologies such as congestive heart failure (CHF). CHF is a syndrome that is characterized by cardiac dysfunction and symptoms of exercise intolerance, including breathlessness or fatigue. Peripheral pathological changes in skeletal muscle, including muscle wasting/atrophy, and a reduction in oxidative fibers, play important roles in exercise intolerance. The incidence of CHF increases with age, and the clinical outcomes of CHF in aging are exacerbated by aging-associated muscle loss (sarcopenia). Both elevated oxidative stress and increased cellular apoptosis have been strongly implicated in the pathogenesis of sarcopenia, a muscle-wasting disease of significant importance in the elderly. Sarcopenia results in a loss of function and reduces the quality of life in the aged, especially in individuals with restricted mobility or extended hospitalization. Mitochondrial dysfunction and loss of mitochondria may contribute to elevated oxidative stress and apoptosis and underlie sarcopenia.

Our research program is targeted to understand muscle growth and loss in conditions that include CHF, aging, denervation and disuse. The three broad areas of inquiry in our laboratory include: (i) understanding cellular and molecular adaptations to muscle hypertrophy/growth and aging, (ii) the role of apoptosis in skeletal and cardiac muscle remodeling during aging (iii) the role of oxidative stress in regulating adaptation and maladaptation to exercise and loading. In addition to studies in human subjects, these projects have included examining several animal models including birds, rats and mice.

Our approach has been to utilize various perturbations including resistance exercise, stretch and aerobic exercise to challenge the skeletal and cardiac muscle systems, and to utilize cellular and molecular probes, genetically modified animals and aged animals to evaluate the responses from the level of the gene to the whole muscle. Our recent work has shown that oxidative stress is elevated with aging and various muscle wasting conditions, and this can be offset via nutritional approaches. In addition, reducing oxidative stress may lead to reduced apoptotic-associated loss of muscle nuclei, thereby reducing the effects of aging-induced muscle loss (sarcopenia). This work has been funded by NIH for almost 20 years.

Grants and Research

RESEARCH (within last three years):

Extramural funding - Active

  • West Virginia Clinical and Translational Science Institute     Alway (PI)    04/01/2013-12/01/2014
    “Phase 1 (T1) Translation of basic to clinical research: Offsetting Sarcopenia with Exercise and Resveratrol”
    The goal of this study is to evaluate the efficacy of resveratrol to improve muscle function, fatigue, and mass in aging with and without an exercise intervention.
    Role: PI
  • Abbott Laboratories 100415    Alway (PI)    01/22/2008-05/30/2014
    Nutritional reduction of muscle wasting in sarcopenia
    The goal of this study is to evaluate the efficacy of nutritional intervention to improve muscle function, fatigue, and mass during conditions of muscle disuse and reuse.
    Role: PI
  • Healthworks Inc.     Alway (PI)    08/01/2013-07/31/2015
    Clinical training for graduate students in Exercise Physiology
    The goal of this project is to provide research training for graduates interested in rehabilitation opportunities with diabetic and cardiac patients.
    Role: PI

Completed extramural funding in past 5 years

  • Healthworks Inc.     Alway (PI)     08/01/2011-07/31/2013
    Clinical training for graduate students in Exercise Physiology
    The goal of this project is to provide research training for graduates interested in rehabilitation opportunities with diabetic and cardiac patients.
    Role: PI
  • 2004 - 2010 NIH/NIA R01AG021530 "Regulation of Id2 in hypertrophy and aging". S.E. Alway Principal Investigator. Goal: The overall goal of this proposal is to define cellular and molecular mechanisms of actions of Id2 in muscle growth in aging.
  • 2009-2011 K01 NIH/NIAAG026337 "The role of Myostatin in Cardiac Hypertrophy and Failure" M. Morissette, Principal Investigator. Goal: To provide career development and training opportunities to facilitate the transition of the investigator to an independent researcher in aging. The scientific goal is to utilize a myostatin-deleted mouse model to better understand the potential role of myostatin in vitro and in vivo in controlling cardiac growth during aging. S.E. Alway, scientific mentor
  • 2002 - 2003 NIH:NCRR "Supplement for Cobre in Signal Transduction and Cancer RR16440" D.F. Flynn, is the P.I. S.E. Alway is a Co-Investigator and user of the facility 9/30/02 to 4/30/03. Goal: Purchase equipment for the protein data analysis of the proteomic center.
  • 2002 - 2003 NIH:NCRR "Mass spectrometry for proteomics" J. Barnett, Principal Investigator. S.E. Alway, Co-Investigator, 5/01/02 to 9/29/03. Goal: Obtaining a mass spectophotometer for protein analysis.
  • 1999 - 2003 NIH, National Institute on Aging, R01AG17143 "MyoD and myogenin in muscle hypertrophy and sarcopenia. S.E. Alway, Principal Investigator. Funded 07-01-99 to 06-30-03. Goal: This project was to identify the role of myoregulatory factors MyoD and myogenin in muscles from old Japanese quail.