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John M Hollander

Associate Professor

Room 110 HSC North - Annex
Morgantown, WV 26506
jhollander@hsc.wvu.edu
P: 304-293-3683
F: 304-293-7105

Associate Professor

Human Performance - Exercise Physiology (SOM)
Faculty

Education

Nutritional Sciences, University of Wisconsin, Madison, WI, PhD, 2000
Mammalian Physiology, University of California, San Diego, CA, BS, 1991

Research

To view Research Interests click HERE

Details


Long Bio

POSITIONS:

  • 2012–present Vice Chair for Research
    Division of Exercise Physiology
    West Virginia University School of Medicine, Morgantown, WV
  • 2011–present Associate Professor (tenured)
    West Virginia University School of Medicine, Morgantown, WV
  • 1/2009 – present Director of Graduate Studies, Division of Exercise Physiology
  • 7/2005 - present Assistant Professor
    West Virginia School of Medicine
    Division of Exercise Physiology
  • 7/2004 - 7/2005 Assistant Project Scientist Step II
    University of California, San Diego Department of Medicine
    Supervisor – Wolfgang Dillmann, M.D.
  • 8/2000 - 7/2004 Postdoctoral Fellow
    University of California, San Diego Department of Medicine
    Supervisor – Wolfgang Dillmann, M.D.

PROFESSIONAL SOCIETIES:

  • American Heart Association
  • American College of Sports Medicine
  • American College of Sports Medicine, Mid-Atlantic Chapter
  • American Physiological Society
  • International Society for Heart Research
  • Society for Free Radical Biology and Medicine
  • United Mitochondrial Disease Foundation

ACADEMIC AND PROFESSIONAL HONORS:

  • 2010-present Named as Fellow of the American Heart Association, Council on BCVS
  • 2009 West Virginia University Dean’s Award for Excellence in Research
  • 3/1/05 - 6/30/05 Minority Investigator Research Supplement (MIRS)
    NIH, National Heart, Lung, and Blood
    “Cardiac Ischemia and Heat Shock Proteins”
  • 8/1/00 - 2/28/05 National Research Service Award Postdoctoral Traineeship
    National Institute of Health
  • 7/1/98 - 6/30/99 American Heart Association Predoctoral Fellowship
    American Heart Association
    “Exercise and Antioxidant Enzyme Gene Regulation in Myocardium”
  • 9/1/98 - 11/30/98 Glenn Foundation/AFAR Scholarship
    American Federation for Aging Research
    “Aging and Antioxidant Enzyme Gene Regulation: Superoxide Dismutase Brought to Focus”
  • 9/1/98 - 5/31/99 Advanced Opportunity Fellowship
    UW-Madison Graduate School
  • 1/1/97 - 5/31/98 Advanced Opportunity Fellowship
    UW-Madison Graduate School
  • 1/1/94 - 12/31/96 National Research Service Award Predoctoral Traineeship
    National Institute of Health
  • 9/1/93 - 1/1/94 Nutritional Sciences Fellowship
    Interdepartmental Graduate Program Nutritional Science

Publications

  • Leeuwenburgh, C., S. Leichtweis, J. Hollander, R. Fiebig, M. Gore, and L.L. Ji. Effect of acute exercise on glutathione deficient heart. Mol. Cell. Biochem. 156:17-24, 1996.
  • Leeuwenburgh, C., J. Hollander, S. Leichtweis, M. Griffiths, M. Gore, and L.L. Ji.
    Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific. Am. J. Physiol. 272(41):R363-R369, 1997.
  • Hollander, J., M. Gore, R. Fiebig, R. Mazzeo, S. Oh-ishi, H. Ohno, and L.L. Ji. Spaceflight down-regulates antioxidant defense systems in rat liver. Free Rad. Biol. Med. 24:385-390, 1997.
  • Kim, Moon-ju, J. M. Aiken, T. Havighurst, J. Hollander, M. O. Ripple, and R. Weindruch. Adult-onset energy restriction of Rhesus monkeys attenuates oxidative-stress induced cytokine expression by peripheral blood mononuclear cells. J. Nutr. 127:2293-2301, 1997.
  • Ji, L.L., C. Leeuwenburgh, S. Leichtweis, R. Fiebig, J. Hollander, and M. Gore. Antioxidant protection of glutathione in exercise. In Proceedings of the VIII Int. Society for Free Rad. Res. Prous Publications, Barcelona, Spain.
  • Gore, M., R. Fiebig, J. Hollander, C. Leeuwenburgh, and L.L. Ji. Exercise training alters antioxidant enzyme activity, protein content, and mRNA abundance in rats. Can. J. Physiol. Pharm. 76:1-7, 1998.
  • Ji, L.L., C. Leeuwenburgh, S. Leichtweis, M. Gore, Russel Fiebig, John Hollander, and Jeffery Bejma. Oxidative Stress and Aging: Role of Exercise and Its Influences on Antioxidant Systems. In: Towards Prolongation of the Healthy Life Span. Ann. N.Y. Acad. Sci. 845:102-117, 1998.
  • Ji, L.L. and J. Hollander. Antioxidant Defense. In: Free Radicals in Exercise and Aging. (Ed. Z. Radak). Human Kinetics Publishing, Champaign, IL. pp. 25-47, 2001.
  • Hollander, J., R. Fiebig, M. Gore, J. Bejma, T. Ookawara, H. Ohno, and L.L. Ji. Superoxide dismutase gene expression: fiber-specific adaptation to endurance training. Am. J. Physiol. 277:R856-R862, 1999.
  • Hollander, J., J. Bejma, T. Ookawara, H. Ohno, and L.L. Ji. Superoxide dismutase gene expression: fiber-specific effect of age. Mech. Ageing Develop. 116(1):33-45, 2000.
  • Fiebig, R., J. Hollander, and L.L. Ji. Exercise down-regulation of hepatic fatty acid Synthase in streptozotocin-treated rats. J. Nutri. 131(9):2252-2259, 2001.
  • Brickson, S., J. Hollander, D. T. Corr, L. L. Ji, and T. M. Best. Oxidant production and immune response after stretch injury in skeletal muscle. Med. Sci. Sports Exer. 33(12):2010-2015, 2001.
  • Hollander, J., R. Fiebig, M. Gore, T. Ookawara, H. Ohno, and L.L. Ji. Superoxide dismutase gene expression in skeletal muscle: effect on an acute post-exercise time course. Pflugers-Arch. Eur. J. Physiol. 442(3):426-434, 2001.
  • Fiebig, R. G., J. Hollander, D. Ney, R. Bioleau, E. Jeffrey, and L.L. Ji. Exercise training decreases hepatic fatty acid synthase activity and body fat in obese Zucker rats. Med. Sci. Sports Exer. 34(7):1106-1114, 2002.
  • Hollander, J., K. M. Lin, B. T. Scott, W. H. Dillmann. Protection Against Simulated Ischemia-Reoxygenation Damage with Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase and HSP 60 and HSP 10. Free Rad. Biol. Med. 35(7):742-751, 2003.
  • Lin, K. M., J. Hollander, B. Lin, L. Macpherson. W. H. Dillmann. Myocyte protection by 10 kd heat shock protein (HSP10) involves the mobile loop and attenuation of the Ras-GTPase pathway. FASEB J. 18:1004-1006, 2004.
  • Hollander, J., J. L. Martin, D. D. Belke, B. T. Scott, W. H. Dillmann. Overexpression of wild type HSP27 and a HSP27 nonphosphorylatable mutant protects against ischemia/reperfusion injury in a transgenic mouse model. Circulation. 110:3544-3552, 2004.
  • Dieterle, T., M. Meyer, Y. Gu, D. D. Belke, E. Swanson, M. Iwatate, J. Hollander, K. L. Peterson, J. Ross, W. H. Dillmann. Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure. Cardiovasc. Res. 67:678-688, 2005.
  • Sakurai, T., J. Hollander, S. L. Brickson, H. Ohno, L. L. Ji, T. Izawa, T. M. Best. Changes in nitric oxide and inducible nitric oxide synthase following stretch induced injury to the tibialis anterior muscle of rabbit. Jpn. J. Physiol. 55:101-107, 2005.
  • Belke, D. D., B. Gloss, J. Hollander, E. A. Swanson, H. Duplain and W. H. Dillmann.  In Vivo Gene Delivery of HSP70i Adenovirus and Adeno-Associated Virus Preserves Contractile Function in Mouse Heart Following Ischemia-Reperfusion.  Am. J. Physiol. 291:H2905-H2910, 2006.
  • Williamson, C. L., E. R. Dabkowski, W. H. Dillmann, and J. Hollander.  Mitochondria protection from hypoxia/reoxygenation injury with mitochondrial heat shock protein 70 (mthsp70) overexpression. Am. J. Physiol. 294:H249-H256, 2008.
  • Dabkowski, E. R., C. L. Williamson, and J. Hollander.  Mitochondria-Specific Transgenic Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) Attenuates Ischemia/Reperfusion Associated Cardiac Dysfunction.  Free Rad. Biol. Med. 45:855-865, 2008.
  • Dabkowski, E. R., C. L. Williamson, V. C. Bukowski, R. S. Chapman, S. S. Leonard, and J. Hollander.  Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations.  Amer. J. Physiol. 2009 [Epub ahead of press).
  • Williamson, C. L., E. R. Dabkowski, W. A. Baseler, T. L. Croston, S. E. Alway, and J. M. Hollander. Enhanced apoptotic propensity in diabetic cardiac mitochondria: influence of subcellular spatial location. Amer. J. Physiol. 298:H633-H642, 2010. PMID: 19966057
  • Ryan M. J., J. R. Jackson, Y. Hao, C. L. Williamson, E. R. Dabkowski, J. M. Hollander, and S. E. Alway. Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. J Gerontol A Biol Sci Med Sci. 65:815-831, 2010. PMID: 20507922
  • Lin, Y-C, J. Huang, Q. Zhang, J. M. Hollander, J.C. Frisbee, K. Martin, C. Nestor, R.L. Goodman, and H-G Yu. Inactivation of L-type Calcium Channel Modulated by HCN2 Channel. Amer. J. Physiol. 298:C1029-C1037, 2010. PMID: 20164379
  • Dabkowski, E. R., W. A. Baseler, C. L. Williamson, M. Powell, T. T. Razunguzwa, J. C. Frisbee, J. M. Hollander. Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes. Amer. J. Physiol. 299:H529-H540, 2010. PMID: 20543078
  • Drake J.C., S.E. Alway, J. M. Hollander, D. L. Williamson. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Amer. J. Physiol. 299:R1546-R1554, 2010. PMID: 20844264
  • Baseler, W. A., E. R. Dabkowski, C. L. Williamson, T. L. Croston, M. J. Powell, T. T. Razunguzwa, and J. M. Hollander. Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction. Amer. J. Physiol. 300:R186-R200, 2011. PMID:21048079.
  • Hollander, J.M., W.A. Baseler, and E.D. Dabkowski. Proteomic remodeling of mitochondria in heart failure. Congest. Heart Fail. 17:262-268, 2011. PMID: 22103917
  • Vejandla, H., E.R. Dabkowski, J.M. Hollander, and R.W. Brock. C-peptide Restores Mitochondrial Complex I Activity and Prevents Superoxide Generation in High Glucose-Exposed Renal Microvascular Endothelial cells. ISRN Endocrinol. Epub 2012. PMID: 22778984
  • Chen, F., W. Lewis, J.M. Hollander, M.S. Finkel. N-acetylecysteine reverses cardiac myocyte dysfunction in HIV-Tat proteinopathy. J. Appl. Physiol. 113:105-113, 2012. PMID: 22556393.
  • Baseler, W.A., D. Thapa, R. Jagannathan, E.R. Dabkowski, T.L. Croston, and J.M. Hollander. miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart. Amer. J. Physiol. 303:C1244-1251, 2012. PMID: 23034391
  • Fancher, I.S., G.M. Dick, J.M. Hollander. Diabetes mellitus reduces the function and expression of ATP-dependent K+ channels in cardiac mitochondria. Life Sci. 92:664-668, 2013. PMID: 23261529
  • Baseler, W.A., E.R. Dabkowski, R. Jagannathan, D. Thapa, C.E. Nichols, D.L. Shepherd, T.L. Croston, M.J. Powell, T.T. Razunguzwa, D.M. Schnell, and J.M. Hollander. Reversal of mitochondrial proteomic loss in type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase. Amer. J. Physiol. 304:R553-R565, 2013. PMID: 23408027

SELECTED ABSTRACTS: (2002-PRESENT)

  • Hollander, J., K. M. Lin, B. T. Scott, W. H. Dillmann. Protection Against Simulated Ischemia-Reoxygenation Damage with Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase and HSP 60 and HSP 10. Circulation. 106:II-284, 2002.
  • Hollander, J., J. L. Martin, D. D. Belke, B. T. Scott, W. H. Dillmann. Transgenic Overexpression of Wild Type HSP27 and a HSP27 Nonphosphorylatable Mutant Protects Against Ischemia/Reperfusion Injury. Circulation. 108:IV-92, 2003.
  • Lai, C. C., J. Hollander, D. D. Belke, B. T. Scott, W. H. Dillmann, C. Y. Su. Transgenic Overexpression of Constitutive Heat Shock Protein 70 (hsc70) Protects Against Ischemia/Reperfusion Injury. FASEB J. 18:A1244, 2004.
  • Stenbit, A. E., H. Duplain, D. D. Belke, J. Hollander, D. Xiong, D. Summers-Torres, S. C. Froehner, M. E. Adams, K. U. Knowlton. nNOS is primarily localized to the sarcoplasmic reticulum in cardiac myocytes and dependent on 1-syntrophin. Circulation. (Suppl. III) 110:III-198, 2004a.
  • Hollander, J. M., B. T. Scott, D. D. Belke, W. H. Dillmann.  Cardiac myocytes and their mitochondria are protected against ischemia-reoxygenation injury with overexpression of mitochondrial heat shock protein 70 (MtHsp70).  13th Annual Cardiovascular Diversity Research Award Session.  P. 2.  National Heart Lung and Blood Institute, Dallas Texas.  November 12, 2005.
  • Hollander, J. M., B. T. Scott, D. D. Belke, W. H. Dillmann.  Mitochondrial protection from ischemia-reoxygenation injury with mitochondrial heat shock protein 70 overexpression.  FASEB J.  20:A1155, 2006.
  • Williamson, C. L., E. R. Dabkowski, J. M. Hollander.  Contractile dysfunction in the diabetic heart is associated with enhanced apoptosis and decreased hsp25 phosphorylation.  FASEB J.  21(6):A1343, 2007.
  • Dabkowski, E. R., C. L. Williamson, J. M. Hollander.  Increased susceptibility of mitochondrial subpopulations to diabetic cardiomyopathy associated dysfunction.  FASEB J.  21(6):A819, 2007.
  • Dabkowski, E. R., J. M. Hollander, M. Powell, T. Razunguzwa, P. Perrotta.  Biomarker discovery strategy for mitochondrial dysfunction using iTRAQTM and a high throughput MALDI TOF/TOF mass spectrometer.  West Virginia State INBRE/CoBRE meeting, October, 2007.
  • Williamson, C. L., Dabkowski, E. R., J. M. Hollander.  Enhanced apoptotic propensity in diabetic cardiac interfibrillar mitochondria.  FASEB J. 2008 #1238.19.
  • Dabkowski, E. R., Williamson, C. L., J. M. Hollander.  Quantitative proteomic analysis of distinct mitochondrial subpopulations in diabetic myocardium.  FASEB J. 2008 #1226.36.
  • Dabkowski, E. R., Williamson, C. L., Leonard, S. L., Brock, R. W., J. M. Hollander.  Dysfunction in Spatially Distinct Cardiac Mitochondrial Subpopulations During Diabetic Insult.  Mitochondria 2008 Conference.  Abstract #10.7.11.

CV

Current CV

Healthcare


Special Training

Fellowship: Medicine , University of California, San Diego, CA , 2005

Research


Grants and Research

RESEARCH SUPPORT (ACTIVE)

  • Director’s New Innovator Award                    $1,500,000/5 years
    Type 1 Diabetes Pathfinder Award
    NIH/NIDDK
    PI: Hollander
    Mechanisms of Diabetic Cardiomyopathy: Mitochondria
  • Grant In-Aid                                                   $121,000/2 years
    American Heart Association
    PI: Hollander
    Mitochondria Subpopulation Response to Ischemia/Reperfusion Injury
  • Predoctoral Fellowship                                  $42,000/2 years
    American Heart Association
    PI: Dabkowski
    Sponsor: Hollander                         
    Influence of a Diabetic Phenotype on Specific Mitochondrial Subpopulations
  • Graduate Training Grant
    NIH/NHLBI
    PI: Mustafa (Mentor: Hollander)
    Research Training in Cardiovascular and Pulmonary Diseases

RESEARCH SUPPORT (COMPLETED)

  • Beginning Grant In-Aid                                  $121,000/2 years
    American Heart Association
    PI: Hollander
    Myocardial Protection From Ischemia/Reperfusion Injury