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Paul Chantler Directory Photo

Paul D Chantler

Associate Professor
Room 8313 HSS
Morgantown,
WV
26506
Box: 9227
304-293-7105

Credentials

PhD

Positions

Associate Professor
Human Performance - Exercise Physiology (SOM)
Faculty

Program 4: Translational Tobacco Reduction Research
Associate Member
WVU Cancer Institute Research Programs (WVUCI)
Faculty

Education

PhD, Exercise Physiology, Liverpool John Moores University, Liverpool, England, 2004
BS, Sports Science and Exercise Physiology, Liverpool John Moores University, Liverpool, England, 2001

PROFESSIONAL SOCIETIES AND OTHER EXPERIENCES:

  • 2009 - Member, American College of Sports Medicine
  • 2010 - Member, American Physiological Society
  • 2008 - Reviewer, American Journal of Applied Physiology
  • 2010 - Reviewer, European Journal of Applied Physiology

Publications

PEER-REVIEWED PUBLICATIONS

  1. PD Chantler, and Lakatta EG. Arterial-Ventricular Uncoupling with Age and Disease. Frontiers in Vascular Physiology. Front Physiol 2012; 3, 90
  2. PD Chantler, Melenovsky, V. Gerstenblith G, Schulman SP, Becker LC, Ferrucci L, Fleg JL, Lakatta EG, Najjar SS. Use of the Frank-Starling Mechanism during Exercise is Linked to Exercise-Induced Changes in Arterial Load. American Journal of Applied Physiology 2012; 302 (1): H349-H358
  3. PD Chantler, Nussbacher A, Schulman SP, Gerstenblith G, Becker LC, Ferrucci L, Fleg JL, Lakatta EG, Najjar SS. Abnormalities in Arterial-Ventricular Coupling in Older Healthy Persons are Attenuated by Sodium Nitroprusside. American Journal of Applied Physiology; 2011; 300: H1914–H1922
  4. PD Chantler, and Lakatta EG. The Role of Body Size on Cardiovascular Function: Can We See the Meat Through the Fat? Hypertension. 2009; 54: 459-461.
  5. DF Goldspink, George KP, Chantler PD, Clements RE, Sharp L, Hodges G, Stephenson C, Reilly TP, Patwala A, Szakmany T, Tan LB, Cable NT. A Study of Presbycardia, with Gender Differences Favouring Ageing Women. International Journal of Cardiology. 2009; 137 (3): 236-245
  6. PD Chantler, Lakatta EG, Najjar SS. Arterial-Ventricular Coupling: Mechanistic Insights into Cardiovascular Performance at Rest and During Exercise. J Appl Physiol. 2008; 105: 1342-1351.
  7. PD Chantler, Melenovsky V, Schulman SP, Gerstenblith G, Becker LC, Ferrucci L, Fleg JL, Lakatta EG, Najjar SS. The Sex-Specific Impact of Systolic Hypertension and Systolic Blood Pressure on Arterial-Ventricular Coupling at Rest and During Exercise. Am J Physiol. 2008; 295: H145-H153.
  8. PD Chantler, Goldspink DF, Clements RE, Sharp L, Schlosshan D, Tan LB. Congestive Heart Failure: Extent of Cardiac Functional Changes Caused by Aging and Organ Dysfunction. Heart. 2006; 92(5):686-8.
  9. EG Lakatta, and Chantler PD. Payments for Debts Associated with Exercise Can Become Higher As We Age and Limit Exercise Capacity. J Am Coll Cardiol. 2006; 206; 47(5):1058-9
  10. PD Chantler, Clements RE, Sharp L, George KP, Tan LB, Goldspink DF. The Influence of Body Size on Measurements of Overall Cardiac Function. Am J Physiol. 2005; 289(5): H2059-65.

PEER-REVIEWED JOURNAL ABSTRACTS

  1. Fournier SB, Reger B, Donley DA, Bonner DE, Warden BE, Chantler PD. Improving Arterial-Ventricular Coupling Reserve in Patients with Metabolic Disorders through Exercise Training. The FASEB Journal. 2012: 26: ib653
  2. Chantler, PD; Donley, D; Reger, B; Bonner, D; Gilleland, D; Failinger, C; Olfert, M; Olfert, IM. Blunted Chamber Performance in Patients with Metabolic Syndrome to Exercise: Preliminary Evidence: Medicine & Science in Sports & Exercise. 43(5):655, May 2011.
  3. B Reger, Donely D, Bonner D, Failinger C, Olfert IM, Chantler PD. The Effects of Aerobic Exercise Training on Arterial-Ventricular Coupling in Patients with Metabolic Syndrome: A Pilot Study. The FASEB Journal. 2011: 25: ib443
  4. PD Chantler, Nussbacher A, Schulman SP, Gerstenblith G, Fleg JL, Becker LC, Ferrucci L, Lakatta EG, Najjar SS. Attenuating the Age-Associated Deficit in Peak Arterial-Ventricular Coupling with Sodium Nitroprusside. Citation: Medicine & Science in Sports & Exercise: May 2010, Volume 42, Issue 5, p630.
  5. PD Chantler, Ferrucci L, Gerstenblith G, Fleg JL, Schulman SP Melenovsky V, Becker LC, Lakatta EG, Najjar SS. The Change in Arterial Load During Exercise is Associated with Differing Arterial & Left Ventricular Patterns. Citation: Medicine & Science in Sports & Exercise: May, 2009, Volume 41, Issue 5, p68-69
  6. SS Najjar, Chantler PD, Lakatta EG. Age Associated Abnormalities in Heart-Arterial Coupling During Exercise Stress are Abolished by Unloading the Heart with Sodium Nitroprusside. 7th International Workshop on Structure and Function of the Vascular System, March 12-14, 2009
  7. PD Chantler, Ferrucci L, Gerstenblith G, Fleg JL, Schulman SP Melenovsky V, Becker LC, Lakatta EG, Najjar SS. Normal Individuals Who Do Not Increase Arterial Load During Exercise Have a Higher Long Term Mortality. Citation: Journal of the American College of Cardiology, March, 2008, Volume 51, Issue 10, Supplement A174
  8. PD Chantler, Melenovsky V, Schulman SP, Gerstenblith G, Fleg JL, Becker LC, Ferrucci L, Lakatta EG, Najjar SS. Synergistic Effects of Systolic Hypertension and Female Sex on the Arterial-Ventricular Coupling Ratio. FASEB. Citation: FASEB J, 2007, 21: 908.29
  9. PD Chantler, Ferrucci L, Gerstenblith G, Fleg JL, Schulman SP Melenovsky V, Becker LC, Lakatta EG, Najjar SS. Synergistic Effects of Systolic Hypertension and Female Sex on the Arterial-Ventricular Coupling Ratio. American College of Cardiology 56th annual scientific sessions. Citation: Journal of the American College of Cardiology, March 6, 2007, 49, 9, Supplement A.
  10. PD Chantler, Clements RE, Sharp L, Tan LB, and Goldspink DF. Blood pressure generating capacity is a component in measuring overall cardiac function. Journal of Molecular and Cellular Cardiology. 2004; 37: 172 AbA29.
  11. PD Chantler, Clements RE, Sharp L, Tan LB, and Goldspink DF. Cardiac power in the ageing, trained and failing heart. Journal of Molecular and Cellular Cardiology. 2004; 37: 172 AbA30.
  12. PD Chantler, Sharp L, Clements RE, Tan LB, and Goldspink DF. Age-and gender-related changes in cardiac power. Journal of Molecular and Cellular Cardiology. 2004; 37: 172 AbA31.
  13. PD Chantler, Clements RE, Sharp L, Tan LB, and Goldspink DF. BASES - Does Long-term Endurance Training Protect Against an Age-Related Decrease in Cardiac Power? Journal of Sports Sciences; 2004: 22, p 40.
  14. PD Chantler, Tan LB, and Goldspink DF. EMC - Cardiac Power Output and Ageing. Journal of Muscle Research and Cellular Motility. 2003; 24: p 374.
  15. PD Chantler, Doran D, Jones S, and Leatt P. 12th Commonwealth International Sport Conference - Effects of Acute Exercise on Blood Lipid Profiles of HIV+ Individuals undergoing ‘HAART’ Therapy: Preliminary Observations”. Journal of Sports Sciences; 2003: 21 (4), p 315.

BOOK CHAPTERS

Emidio E. Pistilli, Ph.D and Paul D. Chantler, Ph.D “Pathophysiology of the Metabolic Syndrome on the Vasculature and Skeletal Muscle” in Handbook on Metabolic Syndrome: Classification, Risk Factors and Health Impact, edited by CM. Lopez Garcia and P A. Perez Gonzalez. NOVA Publishers 2012

Chantler, PD and Lakatta EG “Heart & Arterial Aging” in Cardiac Adaptations edited by B. Ostadal. Springer. In Press

JOURNAL REVIEWER

  • 2008- American Journal of Applied Physiology
  • 2010- European Journal of Applied Physiology
  • 2012- Journal of Applied Physiology
  • 2012- International Journal of Cardiology
  • 2012- American Journal of Nephrology
  • 2012- Ageing Research Reviews
  • 2012- American Journal of Cardiology

Research Interest

To view my Research Interests click http://www.hsc.wvu.edu/ccrs/Investigators/Chantler

Research Program

Translational Tobacco and Reduction Research (T2R2)

Research Statement

RESEARCH INTERESTS

My laboratory has research interests focusing on how the interaction with aging, lifestyle, and various disease states, in particular the Metabolic Syndrome (MetS), impacts cardiac and arterial structure and function both at rest and during exercise. A recent addition to my research is to develop and examine how various lifestyle interventions can be incorporated in to a high cardiovascular disease risk community setting in Appalachia with the goal of directly improving the cardiovascular health of individuals.

My research goals are to determine:

  • important changes in cardiovascular function with obesity, MetS, and Type 2 diabetes;
  • modulation of those changes by biological factors (e.g., elevated lipids, estrogen deficiency) and lifestyle behaviors (e.g., physical activity/inactivity, diet);
  • the efficacy of lifestyle and pharmacological interventions for reversing adverse changes in cardiovascular function with disease;
  • the integrative (systemic to molecular) biological mechanisms that mediate cardiovascular changes with age and disease and the effects of modulating influences and interventions on those changes.
  • how lifestyle interventions in rural community areas can alter arterial-ventricular function and improve the cardiovascular health of the community.

RESEARCH SUPPORT (ACTIVE)

Clinical Research Program Grant $121,000/2 yr American Heart Association PI: Chantler Cardiac and Arterial Dysfunction in Metabolic Syndrome

Research Foundation Development Grant, $22,100/1 yr West Virginia University PI: Chantler Metabolic Syndrome and Therapeutic Interventions. Role: PI

Grants & Research

RESEARCH GRANTS

  • American Heart Association Clinical Program Research Grant ($121,000), 2011-2013
  • National Swimming Pool Foundation Research Grant ($50,000), 2012-2014
  • WVU Program to Stimulate Competitive Research ($27,100) 2012-2013
  • WVU Research Foundation Development Grant ($22,100), 2011-2012

RESEARCH EXPERIENCE
Assistance Professor, (2009-present)

Non-Invasive Cardiovascular Laboratory, School of Medicine, Department of Human Performance, Division of Exercise Physiology, West Virginia University, Morgantown, WV.
Research Areas: To examine the complex associations between obesity, diabetes and the metabolic syndrome, on the coupling between the heart and arterial system both at rest and during exercise.

Postdoctoral Fellow, (2005-2009)

Laboratory of Cardiovascular Science, Human Cardiovascular Studies Unit,
National Institute on Aging, National Institutes of Health;
Baltimore, MD.
Advisors: Samer S. Najjar, M.D., and Edward G. Lakatta, M.D.
Research Areas: To examine the complex associations between aging, disease and lifestyle on the coupling between the heart and arterial system both at rest and during exercise.

Doctoral Research,(2001-2004)

Laboratory of Cardiovascular & Musculoskeletal Research into Human Development and Ageing. Research Institute for Sport and Exercise Sciences, Liverpool John Moores University; Liverpool, England. Advisors: Prof David G. Goldspink, BSc Ph.D DSc, and Lip-Bun Tan, D Phil M.D.
Research Areas: To categorise the age-and gender-related effects on resting and maximal cardiac power output; a measure of overall cardiac function. (Funded by the British Heart Foundation).