A headshot photo of Rudolph Castellani.

Rudolph Castellani, MD

Professor and Vice-Chair of Pathology Research & Section Chief of Neuropathology

Contact Information

PO Box MS 9203
WVU Department of Pathology, Anatomy and Laboratory Medicine
64 Medical Center Drive
2289 HSC S
Morgantown, WV 26506


  • Department of Pathology, Anatomy, & Laboratory Medicine
  • Department of Neuroscience
  • Rockefeller Neuroscience Institute

Graduate Training

  • MD, Wayne State University


  • Resident, Internal Medicine, University of Michigan
  • Resident, Anatomic Pathology, Wayne State University
  • Fellow, Neuropathology, Case Western Reserve University
  • Post-Fellowship Research, Division of Neuropathology, Case Western Reserve University

Recent Publications

Selected Publications :

Iverson GL, Keene CD, Perry G, Castellani RJ. The need to separate chronic traumatic encephalopathy neuropathology from clinical features. Journal of Alzheimer’s Disease 2018;61(1):17-28

McCrory P, Meeuwisse W, Dvorak J, Aubry M, Bailes J, Broglio S, Cantu RC, Cassidy D, Echemendia RJ, Castellani RJ, Davis GA, Ellenbogen R, Emery C, Engebretsen L, Feddermann-Demont N, Giza CC, Guskiewicz KM, Herring S, Iverson GL, Johnston KM, Kissick J, Kutcher J, Leddy JJ, Maddocks D, Makdissi M, Manley GT, McCrea M, Meehan WP, Nagahiro S, Patricios J, Putukian M, Schneider KJ, Sills A, Tator CH, Turner M, Vos PE. Consensus statement on concussion in sport-the 5th international conference on concussion in sport held in Berlin, October 2016. Br J Sports Med. 2017 Apr 26. pii: bjsports-2017-097699. doi: 10.1136/bjsports-2017-097699. [Epub ahead of print]

Manley GT, Gardner AJ, Schneider KJ, Guskiewicz KM, Bailes J, Cantu RC, Castellani RJ, Turner M, Jordan BD, Randolph C, Dvořák J, Hayden KA, Tator CH, McCrory P, Iverson GL. A systematic review of potential long-term effects of sport-related concussion. Br J Sports Med. 2017 Apr 28. pii: bjsports-2017-097791. doi: 10.1136/bjsports-2017-097791. [Epub ahead of print]

Castellani RJ, Perry G. Dementia Pugilistica Revisited. Journal of Alzheimer’s Disease 2017;60(4):1209-1221

Castellani RJ, Mojica G, Schwartzbauer G, Hersh, DS. Symptomatic acute on chronic subdural hematoma: A clinicopathologic study. American Journal of Forensic Medicine and Pathology 2017 Mar 18. doi: 10.1097/PAF.0000000000000300. [Epub ahead of print]

Castellani RJ, Mojica G, Perry G. The Role of the Iron Stain in Assessing Intracranial Hemorrhage. Open Neurol J. 2016 Oct 28;10:136-142.

Castellani RJ, Schmidt CJ. Injury Biomechanics and abusive head trauma. Journal of Forensic Science and Medicine 2018;4(2):91-100

Tripathy A, Dean S, deJong JL, Schmidt CJ, Castellani RJ. Is rotational trauma the only relevant pathogenic mechanism in hemorrhagic retinopathy of shaken baby syndrome? Journal of Forensic Science and Medicine 2018;4(2):104-107.

Castellani RJ, deJong JL, Schmidt CJ. Homicidal abuse of young children: A historical perspective. Journal of Forensic Science and Medicine 2017;3(2):97-110

Sajedi PI, Gonzalez JN, Cronin CA, Kouo T, Steven A, Zhuo J, Thompson O, Castellani R, Kittner SJ, Gandhi D, Raghavan P. Carotid Bulb Webs as a Cause of "Cryptogenic" Ischemic Stroke. AJNR Am J Neuroradiol. 2017 May 11. doi: 10.3174/ajnr.A5208. [Epub ahead of print]

Isaac CV, Cornelison JB, Castellani RJ, deJong JL. A Unique Type of Birth Trauma Mistaken for Abuse. J Forensic Sci. 2017 Jun 12. doi: 10.1111/1556-4029.13557. [Epub ahead of print]

Connolly NP, Stokum JA, Schneider CS, Ozawa T, Xu S, Galisteo R, Castellani RJ, Kim AJ, Simard JM, Winkles JA, Holland EC, Woodworth GF. Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer. PLoS One. 2017 Mar 30;12(3):e0174557. doi: 10.1371/journal.pone.0174557. eCollection 2017.

Castellani RJ, Correia SC, Moreira PI, Perry G. Tackling Alzheimer’s Disease by Targeting Oxidative Stress and Mitochondria. In: Developing Therapeutics for Alzheimer’s Disease. 2016. Chapter 18. Pp 477-502.

Molecular Mapping Alzheimer's Disease: MALDI Imaging of Formalin-fixed, Paraffin-embedded Human Hippocampal Tissue. Kelley AR, Perry G, Bethea C, Castellani RJ, Bach SB. Open Neurol J. 2016 Sep 30;10:88-98.

Iverson GL, Gardner AJ, McCrory P, Zafonte R, Castellani RJ. A critical review of chronic traumatic encephalopathy. Neurosci Biobehav Rev. 2015 Jul 14. pii: S0149-7634(15)00134-7.

Castellani RJ. Chronic Traumatic Encephalopathy: A paradigm in search of evidence? Lab Invest. 2015 Apr 13. doi: 10.1038/labinvest.2015.54. [Epub ahead of print]

Davis GA, Castellani RJ, McCrory P. Neurodegeneration and sport. Neurosurgery. 2015 Jun;76(6):643-56

Castellani RJ, Perry G, Iverson GL. Chronic Effects of Mild Neurotrauma: Putting the Cart before the Horse? Journal of Neuropathology and Experimental Neurology 2015 Jun;74(6):493-9.

Pelcovits A, Marriotti R, Heath J, Perry G, Castellani RJ. Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid- Fifties: What Do We Really Know About Environmental Factors? The Open Neurology Journal 2015;9:1-3.

Castellani RJ, Perry G. The complexities of the pathology-pathogenesis relationship in Alzheimer Disease. Biochemical Pharmacology 2014;88;4:671-676.

Fornicola  W, Pelcovits A, Li B, Heath J, Perry G, Castellani RJ. Alzheimer Disease Pathology in Middle Age Reveals a Spatial-Temporal Disconnect Between Amyloid-β and Phosphorylated Tau. The Open Neurology Journal 2014;8:22-26.

Tosun C, Kurland DB, Mehta R, Castellani RJ, Dejong JL, Kwon MS, Woo SK, Gerzanich V, Simard JM. Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage. Stroke. 2013 Oct 10.

Hersh DS, Mehta RI, Woodworth GF, Castellani RJ. The molecular pathology of primary brain tumors. Pathology Case Reviews 2013;18(5):210-220.

Castellani RJ. Diagnostic challenges in surgical neuropathology. Pathology Case Reviews 2013;18(6):243.

Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Tredici KD, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 2012;71:362-381.

Castellani RJ, Moreira PI, Perry G, Zhu X. The role of iron as a mediator of oxidative stress in Alzheimer disease. Biofactors 2012;38, 133-138.

Sharma HS, Castellani RJ, Smith MA, Sharma A. The Blood-Brain Barrier in Alzheimer's Disease: Novel Therapeutic Targets and Nanodrug delivery. Int Rev Neurobiol. 2012;102:47-90.

Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PL, Coller JM, Perry G, Lee HG, Tabaton M, Smith MA, Wang X, Zhu X. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Laboratory Investigation 2011; 91:1777-1786.

Castellani RJ, Smith MA. Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'. J Pathol 2011;224:147-152.

Castellani RJ, Zhu X, Perry G. In Memoriam: Mark A. Smith, PhD: Renegade scientist and visionary. J Neuropathol Exp Neurol 70:495-497, 2011.

Castellani RJ, Rolston RK, Smith MA. Alzheimer’s Disease. Disease-a-month 2010;56(9):484-546

Castellani RJ, Zhu X, Lee HG, Smith MA, Perry G. Molecular pathogenesis of Alzheimer's disease: Reductionist versus expansionist approaches. Int J Mol Sci 2009;10:1386-1406.

Castellani RJ, Lee HG, Siedlak SL, Nunomura A, Hayashi T, Nakamura M, Zhu X, Perry G, Smith MA. Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. J Alzheimers Dis 2009;18:447-452.

Shah RS, Lee HG, Xiongwei Z (sic), Perry G, Smith MA, Castellani RJ. Current approaches in the treatment of Alzheimer’s disease. Biomed Pharmacother 2008;62:199-207.

Castellani RJ, Lee HG, Zhu X, Perry G, Smith MA. Alzheimer disease pathology as a host response. J Neuropathol Exp Neurol 2008;67:523-531.

Castellani RJ, Nunomura A, Zhu X, Perry G, Smith MA. Tau phosphorylation: toxic, protective, or none of the above. J Alzheimers Dis 2008;14:377-383.

Castellani RJ, Nunomura A, Rolston RK, Moreira PI, Takeda A, Perry G, Smith MA. Sublethal RNA oxidation as a mechanism for neurodegenerative disease. Int J Mol Sci 2008;9:789-806.

Castellani RJ, Colucci M, Xie Z, Zou W, Li C, Parchi P, Capellari S, Pastore M, Rahbar MH,  Chen SG, Gambetti P. Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt- Jakob disease. Neurology 2004;63:436-442.

Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA. Differential activation of Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neurosci Lett 319:25-28, 2002.disease.

Castellani RJ, Harris PLR, Sayre LM, Fujii J, Taniguchi N, Vitek MP, Founds H, Perry G, Smith MA. Advanced glycation in neurofibrillary pathology of Alzheimer disease: nє-(carboxymethyl) lysine and hexitol-lysine. Free Radic Biol Med 2001;31:175-180.

Castellani RJ, Parchi P, Stahl J, Cohen M, Gambetti P. Early biochemical and pathological changes in Creutzfeldt-Jakob disease: Study of brain biopsies. Neurology 1996;46:1690-1693.

Parchi P, Castellani RJ, Capellari S, Ghetti B, Young K, Chen SG, Farlow M, Dickson DW, Sima AAF, Trojanowski JQ, Petersen RB, Gambetti P. Molecular basis of phenotypic variability in sporadic CJD. Ann Neurol 1996;39:767-778.