A headshot photo of Candice M. Brown.

Candice M. Brown

Assistant Professor

Contact Information

Email
Phone
304-293-0589
Address
PO Box 9128
108 Biomedical Road
BMRC 108
Morgantown, WV 26506

Affiliations

  • Department of Neuroscience
  • Department of Microbiology, Immunology, & Cell Biology
  • Rockefeller Neuroscience Institute

Graduate Training

  • PhD in Genetics and Genomics, Duke University

Fellowship

  • Neuroscience and Endocrinology, University of California, Davis
  • University of Washington

Research Interests

The long-term research objective of my laboratory is to understand the neuroendocrine and neuroimmune mechanisms that control brain endothelial cell and blood-brain barrier responses to systemic inflammation. My research program addresses how prior acute systemic infections influence stroke severity and accelerate cognitive decline in mouse models of sepsis, ischemic stroke, and Alzheimer’s disease. Our studies will provide insights into how sex differences shape innate inflammatory responses that, in turn, enhance neurological dysfunction and promote neurodegenerative disease.

Research Topics

  1. Sex differences in brain responses to acute systemic inflammation in sepsis, stroke, and Alzheimer's disease
  2. Mechanisms that preserve blood-brain barrier integrity and protect cerebral function in brain microvascular endothelial cells
  3. Brain and peripheral arginine metabolism in stroke and Alzheimer’s disease
 

Techniques and animal models include

Mouse models of acute and chronic inflammation

  • Sepsis - cecal ligation and puncture
  • schemic stroke - permanent and transient middle cerebral artery occlusion
  • Transgenic models of Alzheimer’s disease and vascular dementias

Cell culture

  • Brain endothelial cell primary cultures and hCMEC/D3 cells
  • Astrocyte and microglia primary cultures

Histology and microscopy

  • Alkaline phosphatase histochemistry and cerebral microvessel analysis
  • Stereology
  • Fluorescence and confocal microscopy

Animal behavior

Mass spectrometry

  • Metabolomics
  • Proteomics
  • LAESI: Laser ablation electrospray ionization

Recent Publications

[2017]

[2016]

[2015]

[2014]

[2012]

[2011]

[2010]

Lab Personnel

Sujung Jun, PhD

Research Associate

Wei Wang, MS

Laboratory Technician

Josh Wang

Research Technician

Divine Nwafor

Neuroscience MD/PhD Student