A headshot photo of James P. O'Callaghan.

James P. O'Callaghan, PhD

Head, Molecular Neurotoxicology Laboratory and CDC Distinguished Consultant, NIOSH

Contact Information

Morgantown, WV 26505


  • National Institute of Occupational Safety and Health (NIOSH)
  • Department of Neuroscience
  • Rockefeller Neuroscience Institute

Graduate Training

  • PhD, Neuropharmacology, Emory University


  • NIGMS predoctoral trainee
  • Pharmacology Research Associate Trainee (i.e. NIGMS PRAT FellowNIDA, postdoctoral fellowship (all in neuropharmacology)

Research Interests

Molecular basis of glial responses to neural injury






  •  Miller, D.B. and O’Callaghan, J.P.: Biomarkers of Parkinson’s disease (PD): where we are and where we are going.  Metabolism 64:  S40-6, 2015.


  • O’Callaghan, J.P., Daughtrey, W.C., Clark, C.R., Schreiner, C.A. and White, R.: Health Assessment of Gasoline and Fuel Oxygenate Vapors:  Neurotoxicity Evaluation. Regulatory Toxicol. Pharmacol. 70: S35-S42, 2014.
  • Jones, B.C., O’Callaghan, J.P., Lu, L., Williams, R.W., Alama, G., Miller, D.B. Genetic             Correlational Analysis Reveals no Association between MPP+ and the Severity of Striatal Dopaminergic Damage Following MPTP Treatment in BXD mouse strains.  Neurotoxicol. Teratol. 45: 91-92, 2014.
  • Panos, J.J., O’Callaghan, J.P., Miller, D.B. and Ferguson, S.A.: Effects of developmental methylphenidate (MPH) treatment on monoamine neurochemistry of male and female rats.  Neurotoxicology 45: 70-74, 2014.
  • Elliott, A.S., Huber, J.D., O’Callaghan, J.P., Rosen, C.L. and Miller, D.B.:  A review of sleep deprivation studies evaluating the brain transcriptome. SpringerPlus 3: 728, 2014.

In press/In house review/Submitted

  • Matsumoto, R.R., Seminerio, M.J., Turner, R.C., Robson, M.J., Miller, D.B. and O’Callaghan, J.P.: Methamphetamine-induced toxicity: an updated review on issues relate to hyperthermia. Pharmacol. Ther. (in press).
  • Gray, T.M., Steup, D., Roberts, L.G., O’Callaghan, J.P., Hoffman, G., Schreiner, C. and Clark, C.R.: Health Assessment of Gasoline and Fuel Oxygenate Vapors: Reproductive Toxicity Assessment. Regulatory Toxicol Pharmacol. (in press).
  • O’Callaghan, J.P., Kelly, K.A., Locker, A.R., Miller, D.B. and Lasley, S.M.: Corticosterone Primes the  Neuroinflammatory Response to DFP in Mice:  Potential Animal Model of  Gulf War Illness J. Neurochem.  2015 Mar 5. doi: 10.1111/jnc.13088.
  • Roberts R., Aschner M., Calligaro D., Guilarte T.R., Hanig J.P., T Herr D., Hudzik, T.J., Jeromin, A., Kallman M.J., Liachenko S., Lynch J.J. III, Miller D.B., Moser V.C., O’Callaghan J., Slikker W. Jr., Paule, M.G. Translational Biomarkers of Neurotoxicity: the Way Forward?  Tox Sci. (in house review)
  • White, R.F., Steele, L., O’Callaghan, J.P., Sullivan, K., Barlow, C., Binns, J.H., Bloom, F.E., Bunker, J.A., Crawford, F., Golomb, B.A., Graves, J.C., Hardie, A., Klimas, N,  Knox, M, Meggs, W., Melling, J., Ondra, S.L., Philbert, M.A., Grashow, R.: Gulf War illness and other health problems in veterans of the 1990-1991 Gulf War:  Effects of exposures to neurotoxicants.  Cortex (submitted).
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