A headshot photo of James J. Mahoney III.

James J. Mahoney III, PhD

Associate Professor/Clinical Neuropsychologist

Contact Information

930 Chestnut Ridge Road
Morgantown, WV 26505


  • Behavioral Medicine & Psychiatry
  • Department of Neuroscience
  • Rockefeller Neuroscience Institute

Graduate Training

  • University of Houston, Ph.D. in Counseling Psychology
  • Pepperdine University (Los Angeles, CA), M.A.


  • Clinical Neuropsychology Internship - University of Oklahoma Health Sciences Center
  • Clinical Neuropsychology Fellowship - University of Virginia

Research Interests



Research Interests


My specific areas of research focus includes cognitive sequelae related to substance use as well as the investigation of various forms of neuromodulation, including deep brain stimulation, focused ultrasound, and transcranial magnetic stimulation for the treatment of substance use disorders. My current interests emerged from my previous research work as a Clinical Research Manager at the University of California, Los Angeles and the Baylor College of Medicine where the primary focus of the laboratories was Phase I medication development for stimulant use disorders. During this time, while the primary outcomes of the clinical trials were safety and initial efficacy of the medications, I was able to carve out my own niche that included evaluating whether these compounds impacted cognition as some of these agents had cognitive enhancing properties.


Research Topics:


  1. Investigating Novel Treatments for Substance Use Disorder
  2. Neuropsychological Sequelae Associated with Substance Use Disorder


Research Topics:

  1. Investigating Novel Treatments for Opioid Use Disorder
  2. Neuropsychological Sequelae Associated with Opioid Use Disorder

Recent Publications

Research Manuscripts (Peer-Reviewed)


*Abbreviated list from 68 total peer-reviewed published manuscripts


Complete List of Published Works: https://www.ncbi.nlm.nih.gov/myncbi/189OsqqAyVeQS/bibliography/public/


  1. Mahoney, III, J.J., Kalechstein, A.D., De Marco, A.P., Newton, T.F. & De La Garza, II, R. (2017). The relationship between premorbid IQ and neurocognitive functioning in individuals with cocaine use disorders. Neuropsychology, 31, 311-318.
  2. Mahoney, III, J.J., Bajo, S.D., De Marco, A.P., Arredondo, B.C. & Broshek, D. K. (2017). Referring providers’ preferences and satisfaction with neuropsychological services. Archives of Clinical Neuropsychology, 32, 427-436.
  3. Mahoney, III, J.J., Haile, C.N., De La Garza, II, R., Thakkar, H., & Newton, T.F. (2017). Electrocardiographic characteristics in individuals with cocaine use disorder. American Journal on Addictions, 26, 221-227.
  4. Mahoney, III, J.J., Kalechstein, A.D., Newton, T.F. & De La Garza, II, R. (2017). The limited impact that cocaine use patterns have on neurocognitive functioning in individuals with cocaine use disorder. Journal of Psychopharmacology, 31, 989-995.
  5. Mahoney, III, J.J. (2019). Cognitive Dysfunction in Individuals with Cocaine Use Disorder: Potential Moderating Factors and Pharmacological Treatments. Experimental and Clinical Psychopharmacology, 27, 203-214.
  6. Mahoney, III, J.J., Marshalek, P.J., Rezai, A., Lander, L.R., Berry, J.H., & Haut, M.W. (2020). A Case Report Illustrating the Effects of Repetitive Transcranial Magnetic Stimulation on Cue-Induced Craving in an Individual with Opioid and Cocaine Use Disorder. Experimental and Clin. Psychopharmacology, 28, 1-5.
  7. Mahoney, III, J.J., Hanlon, C.A., Marshalek, P.J., Rezai, A., & Krinke, L. (2020). Transcranial Magnetic Stimulation, Deep Brain Stimulation, and Other Forms of Neuromodulation for Substance Use Disorders: Review of Modalities and Implications for Treatment. Journal of Neurological Sciences, 418, 117149.
  8. Mahoney, III, J.J., Winstanley, E., Lander, L.R., Berry, J.H., Marshalek, P.J., Haut, M.W., Marton, J., Kimble, W., Armistead, M., Wen, S., Cai, Y., & Hodder, S. (2020). High Prevalence of Co-Occurring Substance Use in Opioid Use Disorder.  Addictive Behaviors. 114, 106752.
  9. Mahoney, III, J.J., Haut, M., Hodder, S., Zheng, W., Lander, L., Berry, J., Farmer, D.L., Marton, J.L., Brandmeir, N., Ranjan, M., Finomore, V., Hensley, J.L., Aklin, W.M., Wang, G., Tomasi, D., Shokri-Kojori, E., & Rezai, A. (2021). Deep Brain Stimulation of the Nucleus Accumbens/Ventral Capsule for Co-occurring Opioid and Benzodiazepine Use Disorder. Experimental and Clinical Psychopharmacology, 29, 210-215.
  10. Mahoney, III, J.J., Koch-Gallup, N., Scarisbrick, D.M., & Rezai, A.R. (2022). Deep Brain Stimulation for Psychiatric Disorders and Behavioral/Cognitive-Related Indications: Review of the Literature and Implications for Treatment. Journal of Neurological Sciences, 437, 120253.