Marc W. Haut, PhD, ABPP-CN

Director of Memory Health Clinic, Rockefeller Neuroscience Institute

Contact Information

Send an Email

Phone: 304-293-6276

Address: PO Box 9301
Rockefeller Neuroscience Institute
33 Medical Center Drive
Morgantown, WV 26505

View Directory Profile View Website

Affiliations

Department of Behavioral Medicine & Psychiatry
Department of Neuroscience
Department of Neurology
Department of Radiology
Rockefeller Neuroscience Institute

Research Interests

My primary research interests are in the study of human memory, episodic and working memory. Structural (MRI Volumetrics and Diffusion Tensor Imaging) and functional neuroimaging (PET activation and fMRI) are used to study both normal and clinical populations with a particular focus on the effects of age and of toxins on human memory, brain structure, and function.

Age-related Changes in Brain Structure and Function

We are using MRI techniques (fMRI, Volumetrics and Diffusion Tensor Imaging) to study how the brain changes with age as a function of intelligence and cognitive reserve.

Structural and Functional Changes to the Brain After Toxic Exposure

We are completing an R01 in collaboration with Dr. Lisa Morrow at the University of Pittsburgh where we used MRI Volumetrics, PET activation, and Neuropsychological Testing to study the effects of long-term exposure to solvents on brain structure and function.

In collaboration with Dr. Jame Abraham we are also studying the effects of chemotherapy for breast cancer on brain white matter.

Brain Structure and Function Related to Memory Processes

We have ongoing studies to examine the brain structures involved with memory in healthy individuals as well as patients with epilepsy.

Publications

2024

Keifer E, Hartzell JW, McCuddy WT, Lindberg KE, Haut MW. Neurobehavioral exam. In Parsons MW, Braun MM (Eds.), Clinical neuropsychology: A pocket handbook for assessment (4th ed) 2024:123-150. American Psychological Association. DOI: 10.1037/0000383-006

Keith CM, Haut MW, D'Haese PF, Mehta RI, Vieira Ligo Teixeira C, Coleman MM, Miller M, Ward M, Navia RO, Marano G, Wang X, McCuddy WT, Lindberg K, Wilhelmsen KC. More Similar than Different: Memory, Executive Functions, Cortical Thickness, and Glucose Metabolism in Biomarker-Positive Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia. J Alzheimers Dis Rep 2024;8(1):57-73. PMID: 38312533. PMCID: PMC10836603. DOI: 10.3233/ADR-230049

Mahoney JJ, Miller LE, Haut MW. Chapter 38: Substance abuse, prescribed medications, and toxin exposure. In: Boyle GJ, Stern Y, Stein DJ, Sahakian BJ, Golden CJ, Lee TMC, Chen SHA (eds), The SAGE Handbook of Clinical Neuropsychology: Clinical Neuropsychological Disorder 2024. SAGE Publications Ltd. ISBN: 9781529717754

Piamjariyakul U, McKenrick SR, Smothers A, Giolzetti A, Melnick H, Beaver M, Shafique S, Wang K, Carte KJ, Grimes B, Haut MW, Navia RO, Patrick JH, Wilhelmsen K. Developing, implementing, and evaluating the visiting Neighbors' program in rural Appalachia: A quality improvement protocol. PLoS One 2024;19(1):e0296438. PMID: 38166130. PMCID: PMC10760886. DOI: 10.1371/journal.pone.0296438

Rezai AR, D'Haese PF, Finomore V, Carpenter J, Ranjan M, Wilhelmsen K, Mehta RI, Wang P, Najib U, Vieira Ligo Teixeira C, Arsiwala T, Tarabishy A, Tirumalai P, Claassen DO, Hodder S, Haut MW. Ultrasound Blood-Brain Barrier Opening and Aducanumab in Alzheimer's Disease. N Engl J Med 2024;390(1):55-62. PMID: 38169490. DOI: 10.1056/NEJMoa2308719

2023

Buetefisch CM, Haut MW, Revill KP, Shaeffer S, Edwards L, Barany DA, Belagaje SR, Nahab F, Shenvi N, Easley K. Stroke lesion volume and injury to motor cortex output determines extent of contralesional motor cortex reorganization. Neurorehabilitation & Neural Repair 2023;37(2-3):119-130. PMID: 36786394. PMCID: PMC10079613. DOI: 10.1177/15459683231152816

Butts AM, Haut MW. Introductory editorial to the special issue: Alzheimer's disease biomarkers and cognitive functioning along the Alzheimer's continuum. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2023:1-5. Epub ahead of print. PMID: 37632292. DOI: 10.1080/13825585.2023.2249190

Coleman MM, Keith CM, Wilhelmsen K, Mehta RI, Vieira Ligo Teixeira C, Miller M, Ward M, Navia RO, McCuddy WT, D'Haese PF, Haut MW. Surface-based correlates of cognition along the Alzheimer's continuum in a memory clinic population. Front Neurol 2023;14:1214083. PMID: 37731852. PMCID: PMC10508059. DOI: 10.3389/fneur.2023.1214083

Mahoney JJ, Haut MW, Carpenter J, Ranjan M, Thompson-Lake DGY, Marton JL, Zheng W, Berry JH, Tirumalai P, Mears A, D’Haese P, Finomore VS, Hodder SL, Rezai AR. Low-intensity focused ultrasound targeting the nucleus accumbens as a potential treatment for substance use disorder: safety and feasibility clinical trial. Frontiers in Psychiatry 2023;14. DOI: 10.3389/fpsyt.2023.1211566

Mehta RI, Carpenter JS, Mehta RI, Haut MW, Wang P, Ranjan M, Najib U, D'Haese PF, Rezai AR. Ultrasound-mediated blood-brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer's disease. Fluids Barriers CNS 2023;20(1):46. PMID: 37328855. PMCID: PMC10276371. DOI: 10.1186/s12987-023-00447-y

Rezai AR, Mahoney JJ, Ranjan M, Haut MW, Zheng W, Lander LR, Berry JH, Farmer DL, Marton JL, Tirumalai P, Mears A, Thompson-Lake DGY, Finomore VS, D'Haese PF, Aklin WM, George DT, Corrigan JD, Hodder SL. Safety and feasibility clinical trial of nucleus accumbens deep brain stimulation for treatment-refractory opioid use disorder. Journal of Neurosurgery 2023:1-9. Epub ahead of print. PMID: 37329519. DOI: 10.3171/2023.4.JNS23114

2022

Bossarte RM, Kessler RC, Nierenberg AA, Chattopadhyay A, Cuijpers P, Enrique A, Foxworth PM, Gildea SM, Belnap BH, Haut MW, Law KB, Lewis WD, Liu H, Luedtke AR, Pigeon WR, Rhodes LA, Richards D, Rollman BL, Sampson NA, Stokes CM, Torous J, Webb TD, Zubizarreta JR. The Appalachia Mind Health Initiative (AMHI): a pragmatic randomized clinical trial of adjunctive internet-based cognitive behavior therapy for treating major depressive disorder among primary care patients. Trials 2022;23(1):520. PMID: 35725644. PMCID: PMC9207842. DOI: 10.1186/s13063-022-06438-y

Keith CM, Haut MW, Wilhelmsen K, Mehta RI, Miller M, Navia RO, Ward M, Lindberg K, Coleman M, McCuddy WT, Deib G, Giolzetti A, D'Haese PF. Frontal and temporal lobe correlates of verbal learning and memory in aMCI and suspected Alzheimer's disease dementia. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2022;11:1-17. PMID: 36367308. DOI: 10.1080/13825585.2022.2144618

Keith CM, McCuddy WT, Lindberg K, Miller LE, Bryant K, Mehta RI, Wilhelmsen K, Miller M, Navia RO, Ward M, Deib G, D'Haese PF, Haut MW. Procedural learning and retention relative to explicit learning and retention in mild cognitive impairment and Alzheimer's disease using a modification of the trail making test. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2022;22:1-18. PMID: 35603568. DOI: 10.1080/13825585.2022.2077297

Revill KP, Barany DA, Vernon I, Rellick S, Caliban A, Tran J, Belagaje SR, Nahab F, Haut MW, Buetefisch CM. Evaluating the Abnormality of Bilateral Motor Cortex Activity in Subacute Stroke Patients Executing a Unimanual Motor Task With Increasing Demand on Precision. Front Neurol 2022;13:836716. PMID: 35693005. PMCID: PMC9174784. DOI: 10.3389/fneur.2022.836716

Rezai AR, Ranjan M, Haut MW, Carpenter J, D'Haese PF, Mehta RI, Najib U, Wang P, Claassen DO, Chazen JL, Krishna V, Deib G, Zibly Z, Hodder SL, Wilhelmsen KC, Finomore V, Konrad PE, Kaplitt M. Focused ultrasound-mediated blood-brain barrier opening in Alzheimer's disease: long-term safety, imaging, and cognitive outcomes. J Neurosurg 2022;4:1-9. PMID: 36334289. DOI: 10.3171/2022.9.JNS221565

2021

Mahoney JJ, Haut MW, Hodder SL, Zheng W, Lander LR, Berry JH, Farmer DL, Marton JL, Ranjan M, Brandmeir NJ, Finomore VS, Hensley JL, Aklin WM, Wang GJ, Tomasi D, Shokri-Kojori E, Rezai AR. Deep brain stimulation of the nucleus accumbens/ventral capsule for severe and intractable opioid and benzodiazepine use disorder. Experimental and Clinical Psychopharmacology 2021;29(2):210-5. PMID: 34043402. DOI: 10.1037/pha0000453

Mahoney JJ, Winstanley EL, Lander LR, Berry JH, Marshalek PJ, Haut MW, Marton JL, Kimble WD, Armistead, Wen S, Cai Y, Hodder SL. High prevalence of co-occurring substance use in individuals with opioid use disorder. Addictive Behaviors 2021;114:106752. PMID: 33348147. DOI: 10.1016/j.addbeh.2020.106752

Mehta RI, Carpenter JS, Mehta RI, Haut MW, Ranjan M, Najib U, Lockman P, Wang P, D'haese PF, Rezai AR. Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease. Radiology 2021;298(3):654-662. PMID: 33399511. PMCID: PMC7924515. DOI: 10.1148/radiol.2021200643

Pollini RA, Paquette CE, Drvar T, Marshalek P, Ang-Rabanes M, Feinberg J, Haut MW. A qualitative assessment of discharge against medical advice among patients hospitalized for injection-related bacterial infections in West Virginia. International Journal of Drug Policy 2021;94:103206. PMID: 33765516. DOI: 10.1016/j.drugpo.2021.103206

View More Publications