Marc W. Haut, PhD, ABPP-CN

Research Interests

My primary research interests are in the study of human memory, episodic and working memory. Structural (MRI Volumetrics and Diffusion Tensor Imaging) and functional neuroimaging (PET activation and fMRI) are used to study both normal and clinical populations with a particular focus on the effects of age and of toxins on human memory, brain structure, and function.

Age-related Changes in Brain Structure and Function

We are using MRI techniques (fMRI, Volumetrics and Diffusion Tensor Imaging) to study how the brain changes with age as a function of intelligence and cognitive reserve.

Structural and Functional Changes to the Brain After Toxic Exposure

We are completing an R01 in collaboration with Dr. Lisa Morrow at the University of Pittsburgh where we used MRI Volumetrics, PET activation, and Neuropsychological Testing to study the effects of long-term exposure to solvents on brain structure and function.

In collaboration with Dr. Jame Abraham we are also studying the effects of chemotherapy for breast cancer on brain white matter. 

Brain Structure and Function Related to Memory Processes

We have ongoing studies to examine the brain structures involved with memory in healthy individuals as well as patients with epilepsy.

Recent Publications

Buetefisch, C.M., Revill, K.P, Haut, M.W., Kowalski, G., Wischnewski, M., Pifer, M. Belagaje S., Nahab, F., Cobia D., Hu, X., Drake D., & Hobbs, G. (2018). Abnormally reduced primary motor cortex output is related to impaired hand function in chronic stroke. Journal of Neurophysiology.  doi:10.1152/jn.00715.2017

Haut MW, Hogg JP, Marshalek PJ, Suter BC, Miller LE. Amnesia Associated with Bilateral Hippocampal and Bilateral Basal Ganglia Lesions in Anoxia with Stimulant Use. Front Neurol. 2017 Feb 8;8:27. doi: 10.3389/fneur.2017.00027. eCollection 2017. PMID: 28228745 https://www.ncbi.nlm.nih.gov/pubmed/28228745

Hartzell JW, Geary R, Gyure K, Chivukula VR, Haut MW. Completed suicide in an autopsy-confirmed case of early onset Alzheimer's disease. Neurodegener Dis Manag. 2018 Apr;8(2):81-88. doi: 10.2217/nmt-2017-0045. Epub 2018 Jan 10. https://www.ncbi.nlm.nih.gov/pubmed/29319406

Duru UB, Pawar G, Barash JA, Miller LE, Thiruselvam IK, Haut MW. An Unusual Amnestic Syndrome Associated With Combined Fentanyl and Cocaine Use. Annals of Internal Medicine. [Epub ahead of print 30 January 2018]:. doi: 10.7326/L17-0575

Kesar TM, Belagaje SR, Pergami P, Haut MW, Hobbs G, Buetefisch CM. Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults. Brain Res. 2017 Sep 1;1670:106-117. doi: 10.1016/j.brainres.2017.06.015. Epub 2017 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/28633996

Haut, M.W., Hogg, JP, Marshalek, PJ, Suter, BC, & Miller LE. (2017). Amnesia associated with bilateral hippocampal and basal ganglia lesions in anoxia with stimulant use. Frontiers in Neurology.  8:27. doi: 10.3389/fneur.2017.00027

Wischnewski M., Kowalski G., Rink F., Belagaje S., Haut M.W., Hobbs G., & Buetefisch C. (2016). Demand on skillfulness modulates interhemispheric inhibition of motor cortices. Journal of Neurophysiology, 115, 2803-2813.

Moran, M.T., Dean, P.M.., & Haut, M.W. (2015). Summary of Cultural Diversity Chapters. In F. Richard Ferraro. Minority and Cross-Cultural Aspects of Neuropsychological Assessment, 2^nd Edition. Taylor & Francis.  pp515-526

Wiener, J.R., Moran, M.T., & Haut, M.W. (2015). Completed suicide in a case of clinically diagnosed progressive supranuclear palsy. Neurodegenerative Disease Management. 5(4):289-92.

Haut, M. W., Wiener, J., & Moran, M. T. (In Press). Toxins in the CNS. In J. E Morgan & J. H. Ricker Textbook of Clinical Neuropsychology, 2nd Edition. Psychology Press

Buetefisch, C.M, Howard, C., Korb, C.C., Haut, M.W., Shuster, L., Pergami, P., Smith, C., & Hobbs, G. (2014). Conditions for enhancing the encoding of an elementary motor memory by rTMS. Clinical Neurophysiology. Epub ahead of print.

Conditions for enhancing the encoding of an elementary motor memory by rTMS.
Buetefisch CM, Howard C, Korb C, Haut MW, Shuster L, Pergami P, Smith C, Hobbs GR.
Clin Neurophysiol. 2015;126(3):581-593.
PMC4485439.

White matter hyperintensity burden and disability in older adults: is chronic pain a contributor?
Buckalew N, Haut MW, Aizenstein H, Rosano C, Edelman KD, Perera S, Marrow L, Tadic S, Venkatraman V, Weiner D.
PM R. 2013;5(6):471-480.
PMC4023475.

Differences in brain structure and function in older adults with self-reported disabling and nondisabling chronic low back pain.
Buckalew N, Haut MW, Aizenstein H, Morrow L, Perera S, Kuwabara H, Weiner DK.
Pain Med. 2010;11(8):1183-1197.
PMC2925166.

Teaching neuroImages: amnesia due to fornix infarction.
Adamovich BL, Gualberto G, Roberts T, Haut MW, Gutmann L.
Neurology. 2009;73(17):e86

Adjuvant chemotherapy for breast cancer: effects on cerebral white matter seen in diffusion tensor imaging.
Abraham J, Haut MW, Moran MT, Filburn S, Lemieux SK, Kuwabara H.
Clin Breast Cancer. 2008;8(1):88-91.

Chronic pain is associated with brain volume loss in older adults: preliminary evidence.
Buckalew N, Haut MW, Morrow LA, Weiner D.
Pain Med. 2008;9(2):240-248.

Reduced frontal white matter volume in long-term childhood leukemia survivors: a voxel-based morphometry study.
Carey ME, Haut MW, Reminger SL, Hutter JJ, Theilmann R, Kaemingk KL.
AJNR Am J Neuroradiol. 2008;29(4):792-797.

Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial.
Sparks DL, Lemieux SK, Haut MW, Baxter LC, Johnson SC, Sparks LM, Sampath H, Lopez JE, Sabbagh MH, Connor DJ.
Cleve Clin J Med. 2008;75 Suppl 2:S87-S93.

Cognitive impairment with significant brain parenchymal volume loss following standard adjuvant chemotherapy in a patient with breast cancer.
Swayampakula AK, Alkhouri N, Haut MW, Abraham J.
Clin Adv Hematol Oncol. 2007;5(12):985-987.

Corpus callosum volume in railroad workers with chronic exposure to solvents.
Haut MW, Kuwabara H, Ducatman AM, Hatfield GP, Parsons MW, Scott A, Parsons E, Morrow LA.
J Occup Environ Med. 2006;48(6):615-624.