A headshot photo of Marc W. Haut.

Marc W. Haut, PhD, ABPP-CN

Director of Memory Health Clinic, Rockefeller Neuroscience Institute

Contact Information

PO Box 9301
Rockefeller Neuroscience Institute
33 Medical Center Drive
Morgantown, WV 26505


  • Department of Behavioral Medicine & Psychiatry
  • Department of Neuroscience
  • Department of Neurology
  • Department of Radiology
  • Rockefeller Neuroscience Institute

Graduate Training

  • University of North Dakota, Psychology


  • Neuropsychology, University of Missouri-Columbia School of Medicine

Research Interests

My primary research interests are in the study of human memory, episodic and working memory. Structural (MRI Volumetrics and Diffusion Tensor Imaging) and functional neuroimaging (PET activation and fMRI) are used to study both normal and clinical populations with a particular focus on the effects of age and of toxins on human memory, brain structure, and function.


Age-related Changes in Brain Structure and Function

We are using MRI techniques (fMRI, Volumetrics and Diffusion Tensor Imaging) to study how the brain changes with age as a function of intelligence and cognitive reserve.


Structural and Functional Changes to the Brain After Toxic Exposure

We are completing an R01 in collaboration with Dr. Lisa Morrow at the University of Pittsburgh where we used MRI Volumetrics, PET activation, and Neuropsychological Testing to study the effects of long-term exposure to solvents on brain structure and function.

In collaboration with Dr. Jame Abraham we are also studying the effects of chemotherapy for breast cancer on brain white matter. 


Brain Structure and Function Related to Memory Processes

We have ongoing studies to examine the brain structures involved with memory in healthy individuals as well as patients with epilepsy.

Recent Publications


Buetefisch CM, Haut MW, Revill KP, Shaeffer S, Edwards L, Barany DA, Belagaje SR, Nahab F, Shenvi N, Easley K. Stroke lesion volume and injury to motor cortex output determines extent of contralesional motor cortex reorganizationNeurorehabilitation & Neural Repair 2023;37(2-3):119-130. PMID: 36786394. PMCID: PMC10079613. DOI: 10.1177/15459683231152816

Butts AM, Haut MWIntroductory editorial to the special issue: Alzheimer's disease biomarkers and cognitive functioning along the Alzheimer's continuumNeuropsychol Dev Cogn B Aging Neuropsychol Cogn 2023:1-5. Epub ahead of print. PMID: 37632292. DOI: 10.1080/13825585.2023.2249190

Coleman MM, Keith CM, Wilhelmsen K, Mehta RI, Vieira Ligo Teixeira C, Miller M, Ward M, Navia RO, McCuddy WT, D'Haese PF, Haut MWSurface-based correlates of cognition along the Alzheimer's continuum in a memory clinic populationFront Neurol 2023;14:1214083. PMID: 37731852. PMCID: PMC10508059. DOI: 10.3389/fneur.2023.1214083

Mahoney JJ, Haut MW, Carpenter J, Ranjan M, Thompson-Lake DGY, Marton JL, Zheng W, Berry JH, Tirumalai P, Mears A, D’Haese P, Finomore VS, Hodder SL, Rezai AR. Low-intensity focused ultrasound targeting the nucleus accumbens as a potential treatment for substance use disorder: safety and feasibility clinical trial. Frontiers in Psychiatry 2023;14. DOI: 10.3389/fpsyt.2023.1211566

Mehta RI, Carpenter JS, Mehta RI, Haut MW, Wang P, Ranjan M, Najib U, D'Haese PF, Rezai AR. Ultrasound-mediated blood-brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer's diseaseFluids Barriers CNS 2023;20(1):46. PMID: 37328855. PMCID: PMC10276371. DOI: 10.1186/s12987-023-00447-y

Rezai AR, Mahoney JJ, Ranjan M, Haut MW, Zheng W, Lander LR, Berry JH, Farmer DL, Marton JL, Tirumalai P, Mears A, Thompson-Lake DGY, Finomore VS, D'Haese PF, Aklin WM, George DT, Corrigan JD, Hodder SL. Safety and feasibility clinical trial of nucleus accumbens deep brain stimulation for treatment-refractory opioid use disorder. Journal of Neurosurgery 2023:1-9. Epub ahead of print. PMID: 37329519. DOI: 10.3171/2023.4.JNS23114


Bossarte RM, Kessler RC, Nierenberg AA, Chattopadhyay A, Cuijpers P, Enrique A, Foxworth PM, Gildea SM, Belnap BH, Haut MW, Law KB, Lewis WD, Liu H, Luedtke AR, Pigeon WR, Rhodes LA, Richards D, Rollman BL, Sampson NA, Stokes CM, Torous J, Webb TD, Zubizarreta JR. The Appalachia Mind Health Initiative (AMHI): a pragmatic randomized clinical trial of adjunctive internet-based cognitive behavior therapy for treating major depressive disorder among primary care patientsTrials 2022;23(1):520. PMID: 35725644. PMCID: PMC9207842. DOI: 10.1186/s13063-022-06438-y

Keith CM, Haut MW, Wilhelmsen K, Mehta RI, Miller M, Navia RO, Ward M, Lindberg K, Coleman M, McCuddy WT, Deib G, Giolzetti A, D'Haese PF. Frontal and temporal lobe correlates of verbal learning and memory in aMCI and suspected Alzheimer's disease dementiaNeuropsychol Dev Cogn B Aging Neuropsychol Cogn 2022;11:1-17. PMID: 36367308. DOI: 10.1080/13825585.2022.2144618

Keith CM, McCuddy WT, Lindberg K, Miller LE, Bryant K, Mehta RI, Wilhelmsen K, Miller M, Navia RO, Ward M, Deib G, D'Haese PF, Haut MWProcedural learning and retention relative to explicit learning and retention in mild cognitive impairment and Alzheimer's disease using a modification of the trail making testNeuropsychol Dev Cogn B Aging Neuropsychol Cogn 2022;22:1-18. PMID: 35603568. DOI: 10.1080/13825585.2022.2077297

Revill KP, Barany DA, Vernon I, Rellick S, Caliban A, Tran J, Belagaje SR, Nahab F, Haut MW, Buetefisch CM. Evaluating the Abnormality of Bilateral Motor Cortex Activity in Subacute Stroke Patients Executing a Unimanual Motor Task With Increasing Demand on PrecisionFront Neurol 2022;13:836716. PMID: 35693005. PMCID: PMC9174784. DOI: 10.3389/fneur.2022.836716

Rezai AR, Ranjan M, Haut MW, Carpenter J, D'Haese PF, Mehta RI, Najib U, Wang P, Claassen DO, Chazen JL, Krishna V, Deib G, Zibly Z, Hodder SL, Wilhelmsen KC, Finomore V, Konrad PE, Kaplitt M. Focused ultrasound-mediated blood-brain barrier opening in Alzheimer's disease: long-term safety, imaging, and cognitive outcomesJ Neurosurg 2022;4:1-9. PMID: 36334289. DOI: 10.3171/2022.9.JNS221565


Mahoney JJ, Haut MW, Hodder SL, Zheng W, Lander LR, Berry JH, Farmer DL, Marton JL, Ranjan M, Brandmeir NJ, Finomore VS, Hensley JL, Aklin WM, Wang GJ, Tomasi D, Shokri-Kojori E, Rezai AR. Deep brain stimulation of the nucleus accumbens/ventral capsule for severe and intractable opioid and benzodiazepine use disorderExperimental and Clinical Psychopharmacology 2021;29(2):210-5. PMID: 34043402. DOI: 10.1037/pha0000453

Mahoney JJ, Winstanley EL, Lander LR, Berry JH, Marshalek PJ, Haut MW, Marton JL, Kimble WD, Armistead, Wen S, Cai Y, Hodder SL. High prevalence of co-occurring substance use in individuals with opioid use disorder. Addictive Behaviors 2021;114:106752. PMID: 33348147. DOI: 10.1016/j.addbeh.2020.106752

Mehta RI, Carpenter JS, Mehta RI, Haut MW, Ranjan M, Najib U, Lockman P, Wang P, D'haese PF, Rezai AR. Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer DiseaseRadiology 2021;298(3):654-662. PMID: 33399511. PMCID: PMC7924515. DOI: 10.1148/radiol.2021200643

Pollini RA, Paquette CE, Drvar T, Marshalek P, Ang-Rabanes M, Feinberg J, Haut MW. A qualitative assessment of discharge against medical advice among patients hospitalized for injection-related bacterial infections in West Virginia. International Journal of Drug Policy 2021;94:103206. PMID: 33765516. DOI: 10.1016/j.drugpo.2021.103206


Buetefisch, C.M., Revill, K.P, Haut, M.W., Kowalski, G., Wischnewski, M., Pifer, M. Belagaje S., Nahab, F., Cobia D., Hu, X., Drake D., & Hobbs, G. (2018). Abnormally reduced primary motor cortex output is related to impaired hand function in chronic stroke. Journal of Neurophysiology.  doi:10.1152/jn.00715.2017

Haut MW, Hogg JP, Marshalek PJ, Suter BC, Miller LE. Amnesia Associated with Bilateral Hippocampal and Bilateral Basal Ganglia Lesions in Anoxia with Stimulant Use. Front Neurol. 2017 Feb 8;8:27. doi: 10.3389/fneur.2017.00027. eCollection 2017. PMID: 28228745 https://www.ncbi.nlm.nih.gov/pubmed/28228745

Hartzell JW, Geary R, Gyure K, Chivukula VR, Haut MW. Completed suicide in an autopsy-confirmed case of early onset Alzheimer's disease. Neurodegener Dis Manag. 2018 Apr;8(2):81-88. doi: 10.2217/nmt-2017-0045. Epub 2018 Jan 10. https://www.ncbi.nlm.nih.gov/pubmed/29319406

Duru UB, Pawar G, Barash JA, Miller LE, Thiruselvam IK, Haut MW. An Unusual Amnestic Syndrome Associated With Combined Fentanyl and Cocaine Use. Annals of Internal Medicine. [Epub ahead of print 30 January 2018]:. doi: 10.7326/L17-0575

Kesar TM, Belagaje SR, Pergami P, Haut MW, Hobbs G, Buetefisch CM. Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults. Brain Res. 2017 Sep 1;1670:106-117. doi: 10.1016/j.brainres.2017.06.015. Epub 2017 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/28633996

Haut, M.W., Hogg, JP, Marshalek, PJ, Suter, BC, & Miller LE. (2017). Amnesia associated with bilateral hippocampal and basal ganglia lesions in anoxia with stimulant use. Frontiers in Neurology8:27. doi: 10.3389/fneur.2017.00027

Wischnewski M., Kowalski G., Rink F., Belagaje S., Haut M.W., Hobbs G., & Buetefisch C. (2016). Demand on skillfulness modulates interhemispheric inhibition of motor cortices. Journal of Neurophysiology, 115, 2803-2813.

Moran, M.T., Dean, P.M.., & Haut, M.W. (2015). Summary of Cultural Diversity Chapters. In F. Richard Ferraro. Minority and Cross-Cultural Aspects of Neuropsychological Assessment, 2nd Edition. Taylor & Francis.  pp515-526

Wiener, J.R., Moran, M.T., & Haut, M.W. (2015). Completed suicide in a case of clinically diagnosed progressive supranuclear palsy. Neurodegenerative Disease Management. 5(4):289-92.

Haut, M. W., Wiener, J., & Moran, M. T. (In Press). Toxins in the CNS. In J. E Morgan & J. H. Ricker Textbook of Clinical Neuropsychology, 2nd Edition. Psychology Press

Buetefisch, C.M, Howard, C., Korb, C.C., Haut, M.W., Shuster, L., Pergami, P., Smith, C., & Hobbs, G. (2014). Conditions for enhancing the encoding of an elementary motor memory by rTMS. Clinical Neurophysiology. Epub ahead of print.

Conditions for enhancing the encoding of an elementary motor memory by rTMS.
Buetefisch CM, Howard C, Korb C, Haut MW, Shuster L, Pergami P, Smith C, Hobbs GR.
Clin Neurophysiol. 2015;126(3):581-593.

White matter hyperintensity burden and disability in older adults: is chronic pain a contributor?
Buckalew N, Haut MW, Aizenstein H, Rosano C, Edelman KD, Perera S, Marrow L, Tadic S, Venkatraman V, Weiner D.
PM R. 2013;5(6):471-480.

Differences in brain structure and function in older adults with self-reported disabling and nondisabling chronic low back pain.
Buckalew N, Haut MW, Aizenstein H, Morrow L, Perera S, Kuwabara H, Weiner DK.
Pain Med. 2010;11(8):1183-1197.

Teaching neuroImages: amnesia due to fornix infarction.
Adamovich BL, Gualberto G, Roberts T, Haut MW, Gutmann L.
Neurology. 2009;73(17):e86

Adjuvant chemotherapy for breast cancer: effects on cerebral white matter seen in diffusion tensor imaging.
Abraham J, Haut MW, Moran MT, Filburn S, Lemieux SK, Kuwabara H.
Clin Breast Cancer. 2008;8(1):88-91.

Chronic pain is associated with brain volume loss in older adults: preliminary evidence.
Buckalew N, Haut MW, Morrow LA, Weiner D.
Pain Med. 2008;9(2):240-248.

Reduced frontal white matter volume in long-term childhood leukemia survivors: a voxel-based morphometry study.
Carey ME, Haut MW, Reminger SL, Hutter JJ, Theilmann R, Kaemingk KL.
AJNR Am J Neuroradiol. 2008;29(4):792-797.

Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial.
Sparks DL, Lemieux SK, Haut MW, Baxter LC, Johnson SC, Sparks LM, Sampath H, Lopez JE, Sabbagh MH, Connor DJ.
Cleve Clin J Med. 2008;75 Suppl 2:S87-S93.

Cognitive impairment with significant brain parenchymal volume loss following standard adjuvant chemotherapy in a patient with breast cancer.
Swayampakula AK, Alkhouri N, Haut MW, Abraham J.
Clin Adv Hematol Oncol. 2007;5(12):985-987.

Corpus callosum volume in railroad workers with chronic exposure to solvents.
Haut MW, Kuwabara H, Ducatman AM, Hatfield GP, Parsons MW, Scott A, Parsons E, Morrow LA.
J Occup Environ Med. 2006;48(6):615-624.

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