Paul D Chantler, PhD
PO Box 9227
64 Medical Center Drive
Morgantown, WV 26506
My research laboratory has research interests focusing on how the interaction with aging, lifestyle, and various disease states, in particular the Metabolic Syndrome (MetS) and Stroke, impacts cardiac, arterial, and cerebrovascular biology and function. The research goals of my Cardiovascular (CV) Laboratory are to determine:
- important changes in CV function with obesity, MetS, Type 2 diabetes and stroke;
- modulation of those changes by biological factors (e.g., elevated lipids, estrogen deficiency) and lifestyle behaviors (e.g., physical activity/inactivity, diet);
- the efficacy of lifestyle/pharmacological interventions for reversing adverse changes in CV function;
- the integrative (systemic to molecular) biological mechanisms that mediate CV changes with age and disease and the effects of modulating influences and interventions on those changes.
- determine the effects of acute CV responses to a stroke on stroke outcome; and identify approaches to improve stroke outcome in both human and animal models.
I operate both human and basic science labs that allow my research questions to be translated from the bench to clinical human studies. We employ a wide range of contemporary experimental techniques to study our research questions in human subjects, rodent models, and cell culture.
Current research projects:
- My recent work (funded with WVU Stroke NIH COBRE) was to determine the physiological and molecular mechanisms that predispose MetS to a worse ischemic stroke on stroke outcome. This project has both a human and animal arm. Our analogous studies in humans and rodents provide an optimal opportunity to dissect pathophysiological mechanisms that contribute to stroke outcome in patients, which will provide the basis for improved clinical management of stroke.
- My lab is interested in understanding the role of perivascular adipose tissue on aortic and arteriole function, and how CVD disease and exercise affects this interaction.
- Another important research question is, how does daily psychosocial stresses lead to cerebro- and peripheral vascular dysfunction, and the mechanisms by which such vascular dysfunction occurs? Does the presence of existing CVD accentuate the vascular dysfunction with daily psychosocial stresses? And can exercise training mitigated the vascular dysfunction? We are working hard to answer such questions.
Grants and Research
Grants and Contracts (PI unless otherwise stated)
Current Grants and Contracts
WV CTSI Pilot Grant Program ($50,000), PI Chantler, 2017-current
Previously Funded Grants and Contracts
NIH, West Virginia Stroke CoBRE (P20 GM109098); PI Simpkins, 2014- 2017
Project PI: Chantler, ($1,000,000)
WV CTSI Pilot Grant Program ($50,000), PI Chantler, 2014-2016
CereDx “Stroke Biomaker” project ($11,234.99) 2016-2017
Claude Benedum Foundation “Building HOPE in West Virginia” 2014-2015
Project PI: Chantler ($40,000),
National Swimming Pool Foundation Grant ($50,000), PI Chantler, 2012-2014
AHA Clinical Program Research Grant ($121,000), PI Chantler, 2011-2013
WVU Program to Stimulate Competitive Research ($27,100), PI Chantler, 2012-2013
NIH/NHLBI, West Virginia Community Genetics Project (CO-I- 5%) 2012-2014
WVU Research Foundation Development Grant ($22,100), PI Chantler, 2011-2012
Sample of publications
- Brooks S, DeVallance, E., d’Audiffret, A., Tabone, L., Shrader, C., Frisbee S, Frisbee, JC., and Chantler, PD. Metabolic syndrome impairs reactivity and wall mechanics of cerebral resistance arteries in obese zucker rats. American Journal of Physiology; Heart and Circulation. 2015, 309(11):H1846-59 PMID:26475592
- Petrone, AB, O’Connell, GC, Regier, MD, Chantler PD, Simpkins, JW, and Barr, TL. The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. Translational Stroke Research. 2016 Apr;7(2):103-10.PMID: 26515089
- Asano S, Chantler PD, and Barr T. Gene expression profiling in stroke: relevance of blood-brain interaction. Current Opinion in Pharmacology. 2016,26:80-86
- JC Frisbee, JT Butcher, SJ. Frisbee, I.M. Olfert, PD Chantler, LE Tabone, AC d’Audiffret, CD Shrader, AG. Goodwill, PA. Stapleton, SD. Brooks, RW. Brock, and JH Lombard. Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation. 2015. Accepted at American Journal of Physiology; Heart and Circulation. 2016, 310(4):H488-504 Highlighted for AJP: Podcast (2016).
- DeVallance, E., Fournier SB, Lemaster, K., Moore, C., Lee, K., Donley DA, Bonner DE, and Chantler PD., The Effects of Hypertrophic Resistance Exercise Training on Arterial Stiffness in the Metabolic Syndrome? European Journal of Applied Physiology. 2016 May;116(5):899-910 PMID: 26941024
- O'Connell G, Petrone A, Treadway M, Tennant C, Lucke-Wold N, Chantler PD, and Barr TL. Machine Learning Approach Identifies a Pattern of Gene Expression in Peripheral Blood Which Can Accurately Detect Ischemic Stroke. Accepted In Press: npj Genomic Medicine
- Lemaster K, Jackson D, Welsh DG, Brooks SD, Chantler PD, Frisbee JC. Altered distribution of adrenergic constrictor responses contributes to skeletal muscle perfusion abnormalities in metabolic syndrome. In Press. Microcirculation. 2017, 24(2): . PMID: 28036148
- Chantler PD. Arterial Ventricular Uncoupling with Age and Disease and Recoupling with Exercise. Exerc Sport Sci Rev. 2017 Apr;45(2):70-79 PMID: 28072585.
- O'Connell G, Treadway M, Petrone A, Tennant C, Lucke-Wold N, Chantler PD, and Barr TL. Peripheral blood AKAP7 expression as a marker for lymphocyte-mediated post-stroke blood brain barrier disruption. Sci Rep. 2017 Apr 26;7(1):1172. PMID:28446746
- O'Connell GC, Petrone AB, Tennant CS, Lucke-Wold N, Kabbani Y, Tarabishy AR, Chantler PD, and Barr TL. Circulating extracellular DNA levels are acutely elevated in ischaemic stroke and associated with innate immune system activation. Brain Injury. 2017 Jun 6, p1-7
- O'Connell GC, Treadway M, Petrone AB, Tennant CS, Lucke-Wold N, Chantler PD, and Barr TL. Leukocyte dynamics influence reference gene stability in whole blood: Data-driven qRT-PCR normalization is a robust alternative for measurement of transcriptional biomarkers. In Press. Laboratory Medicine
- Mathews A, Famodu O, Olfert M, Murray P, Cuff C, Downes M, Haughey N, Colby S, Chantler PD, Olfert IM, and McFadden J. Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study. Physiological Reports. 2017. Jul 5(13) PMID: 28694327