Vincent S. Setola, PhD
PO Box 9303
Morgantown, WV 26506
Our group is currently interested in the genetics of opioid addiction and treatment outcome. We are working with colleagues at the Chestnut Ridge Comprehensive Opioid Addiction Treatment (COAT) clinic to recruit volunteers into a genetic study of polymorphisms that predict success in the COAT paradigm. We are also working with collaborators at Marshall University to identify, via whole-exome sequencing of mother-baby dyads, susceptibility loci for neonatal abstinence syndrome. Finally, our lab has a mouse model of altered response to drugs of addiction, which we are using to better understand the brain regions and molecular players involved in the signal transduction pathways of drugs of abuse.
- Drug abuse
- G protein signaling
- Human genetics
- Monoamine transporters
- Signal transduction
- Single nucleotide polymorphisms
- Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V (2018). Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. J Psychopharmacol, 32(2): 191-203.
- Schroer AB, Gross JD, Kaski SW, Wix KA, Siderovski DP, Vandenbeuch A, Setola V (2018). Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21). Chem. Senses. 43(5):367-378.
- Gall BJ, Schroer AB, Gross JD, Setola V, Siderovski DP. (2016) Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model. Genes Immun. 17(6):321-7.
- Nicolson SC, Li C, Hirsch ML, Setola V, Samulski RJ. (2016) Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High- Throughput Screens. J Virol. 27;90(16):7019-31.
- Gall BJ, Wilson A, Schroer AB, Gross JD, Stoilov P, Setola V, Watkins CM, Siderovski DP. (2016) Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance. Genes Immun. 17(2):139-47.