Vincent S. Setola, PhD
PO Box 9229
64 Medical Center Drive
Morgantown, WV 26506
Our group is currently interested in the genetics of opioid addiction and treatment outcome. We are working with colleagues at the Chestnut Ridge Comprehensive Opioid Addiction Treatment (COAT) clinic to recruit volunteers into a genetic study of polymorphisms that predict success in the COAT paradigm. We are also working with collaborators at Marshall University to identify, via whole-exome sequencing of mother-baby dyads, susceptibility loci for neonatal abstinence syndrome. Finally, our lab has a mouse model of altered response to drugs of addiction, which we are using to better understand the brain regions and molecular players involved in the signal transduction pathways of drugs of abuse.
- Drug abuse
- G protein signaling
- Human genetics
- Monoamine transporters
- Signal transduction
- Single nucleotide polymorphisms
Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V (2018). Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. J Psychopharmacol, 32(2): 191-203. doi: 1177/0269881117742100. PMID: 29364035.
Joshua D Gross, Shane W Kaski, Adam B Schroer, Kimberly A Wix, David P Siderovski, Vincent Setola, Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants, Journal of Psychopharmachology, Volume: 32 issue: 2, page(s): 191-203, Article first published online: January 24, 2018; Issue published: February 1, 2018 https://doi.org/10.1177/0269881117742100
Gall BJ, Schroer AB, Gross JD, Setola V, Siderovski DP. Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model. Genes Immun. 2016 Sep;17(6):321-7.
Nicolson SC, Li C, Hirsch ML, Setola V, Samulski RJ. Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High- Throughput Screens. J Virol. 2016 Jul 27;90(16):7019-31.
Gall BJ, Wilson A, Schroer AB, Gross JD, Stoilov P, Setola V, Watkins CM, Siderovski DP. Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance. Genes Immun. 2016 Mar;17(2):139-47.