Department of
Neuroscience

Additional Publications

[2015]

  • Doll DM, Rellick SL, Barr TL, Ren X, Simpkins JW. Rapid mitochondrial dysfunction mediates TNF-alpha induced neurotoxicity, J Neurochem. 2015;132(4):443-451. PMID:25492727
  • Doll DN, Hu H, Sun J, Lewis SE, Rellick SL, Simpkins JW, Ren X. Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier. Stroke 46:1681-1689, 2015. PMID: 25922503
  • Ashley B. Petrone; Carolyn C. Rudy; Taura L. Barr, RN; James W. Simpkins; & Miranda N. Reed , Neuroprotective Effects of Estrogen Following Neural Injury, Effects of Estrogens on Traumatic Brain Injury, Ed. K.A. Duncan, Elsevier Press, 2015, pp 91-112.
  • Kunlin Jin, James W. Simpkins, Xunming Ji, Miriam, Ilia Stambler, The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population, Aging and Disease 6: 1-6, 2015.
  • Brandon P. Lucke-Wold, Ryan C. Turner, Aric F. Logsdon, James W. Simpkins, Daniel L. Alkon, Kelly E. Smith,b Yi-Wen Chen, Zhenjun Tan, Jason D. Huber, and Charles L. Rosen, Common Mechanisms of Alzheimer’s disease and Ischemic Stroke: the Role of Protein Kinase C in the Progression of Age-related Neurodegeneration, Journal of Alzheimer’s Disease 43: 711–724, 2015.
  • Aric F. Logsdon, Brandon P. Lucke-wold, Ryan C. Turner, Jason D. Huber, Charles L. Rosen, and James W. Simpkins, Role of microvascular disruption in brain damage from traumatic brain injury, Comprehensive Physiology 5: 1147-1160, 2015.
  • Joshua W. Gatson, James W. Simpkins and Victor V. Uteshev, Proof-of-concept for a high therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury, Brain Research Bulletin 112: 35-41, 2015.
  • Sarkar S, Jun S, Simpkins JW., Estrogen amelioration of Aβ-induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ERβ, AKAP and Drp1. Brain Res. 1616: 101-111, 2015 PMID: 25964165
  • Sun J, Ren X, Simpkins JW. Sequential Up-Regulation of SOD2 and HO-1 by Tert-Butylhydroquinone Protects Mitochondria During Oxidative Stress. Mol Pharmacol. 2015 Sep;88(3):437-49.PMID: 26082377
  • Charles B. Breckenridge, Pragati Sawhney-Coder, Merrill O. Tisdel, Kun Don Yi, James W. Simpkins, Chad D. Foradori, Robert J. Handa, Effect of Age, Duration of Exposure and Dose of Atrazine on Sexual Maturation and the Luteinizing Hormone (LH) Surge in the Female Sprague-Dawley Rat, Birth Defects Res B Dev Reprod Toxicol. 2015 Oct;104(5):204-17.
  • Tan Z, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J, Alkon DL, Simpkins JW, Rosen CL, Huber JD. Bryostatin extends tPA time window to 6h following middle cerebral artery occlusion in aged female rats. Eur J Pharmacol. 2015 Oct 5;764:404-12.
  • Ren X. and JW Simpkins, Deciphering the blood-brain barrier in stroke: Mitochondrial mechanism, Journal of Neuroinfectious Disease, 2015, S2:e002
  • Danielle N. Doll, Elizabeth B. Engler-Chiurazzi, Sara E. Lewis, Heng Hu, Xuefang Ren, Ashely Kerr, James W. Simpkins, Lipopolysaccharide Exacerbates Post-Stroke Behavioral Outcome, Behav Brain Funct. 2015 Oct 13;11(1):32. doi: 10.1186/s12993-015-0077-5. PMID: 26463864
  • Wenjun Li, Nathalie Sumien, Michael Forster, Ran Liu, James Simpkins, Shaohua Yang, Alternative Mitochondrial Electron Transfer for the Treatment of Neurodegenerative Diseases and Cancer: Methylene Blue Connects the Dots, Progress in Neurobiology, In Press, November 5, 2015 2015 Nov 18. pii: S0301-0082(15)30060-5. doi: 10.1016/j.pneurobio.2015.10.005. [Epub ahead of print] Review. PMID: 26603930
  • Engler-Chiurazzi, EB, Singh, M, and Simpkins, JW, From the 90’s to Now: a Brief Historical Perspective on More Than Two Decades of Estrogen Neuroprotection, Brain Research 1633, 96-100, 2015
  • Xuefang Ren and James W. Simpkins, Deciphering the Blood-Brain Barrier Damage in Stroke: Mitochondrial Mechanism, J Neuroinfect Dis. 2015 October ; 6(Suppl 2): doi:10.4172/2314-7326.S2-e002.

[2014]

  • Nicole R. Phillips, James W. Simpkins, PhD, Rhonda K. Roby, Mitochondrial DNA deletions in Alzheimer’s brains: A review, Alzheimer’s and Dementia, 2014 May;10(3):393-400.
  • Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE, Miller RA., Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 2014 Apr; 13(2):273-82.
  • Miranda N. Reed, Danielle N. Doll, James W. Simpkins, and Taura L. Barr, Aging and Stroke: The Human Condition, Proceedings of the 2014 Nestlé Purina Companion Animal Nutrition (CAN) Summit, Pages 31-43, 2014
  • Petrone AB, Gatson JW, Simpkins JW, Reed MN, Non-feminizing estrogens: A novel neuroprotective therapy. Mol Cell Endocrinol. 389: 40-47, 2014.
  • Charles B. Breckenridge, J. Charles Eldridge, James T. Stevens and James W. Simpkins, Symmetrical Triazine Herbicides, Handbook of Pesticide Toxicology, 2nd Edition, In Press, 2014. (IF: N/A)
  • Chad D. Foradori, Prägati Sawhney-Coder, Merrill Tisdel, Kun Don Yi, James W. Simpkins, Robert J. Handa, Charles B. Breckenridge, The Effect of Atrazine Administered by Gavage or in Diet on the LH Surge and Reproductive Performance in Intact Female Sprague-Dawley and Long Evans Rats, Birth Defects Res B Dev Reprod Toxicol. 2014 Jun; 101(3):262-75.
  • Doll DN, Barr TL, Simpkins JW. Cytokines: Their Role in Stroke and Potential Use as Biomarkers and Therapeutic Targets. Aging and Disease 5: 294-306, 2014.
  • Samuel D. Brinkman, Michael D. Frazier, L. A. Norsworthy, Jeff Reese, Donna K. Dellaria, Jacob W. Kinkade, Dawn R. O’Donnell, Jared Benge, Kimberly Brown, Anna Ratka, James W. Simpkins. Initial validation of a computerized dementia screening system involving executive functioning and visual memory. Applied Gerontology 33: 942-962, 2014.
  • Xie L, Sun F, Wang J, Mao X, Xie L, Yang SH, Su DM, Simpkins JW, Greenberg DA, Jin K., mTOR Signaling Inhibition Modulates Macrophage/Microglia-Mediated Neuroinflammation and Secondary Injury via Regulatory T Cells after Focal Ischemia, J Immunol. 192:6009-6019, 2014.
  • Li W, Huang R, Chen Z, Yan LJ, Simpkins JW, Yang SH. PTEN degradation after ischemic stroke: a double-edged sword. Neuroscience. 274:153-161, 2014
  • Qi W, Yue SJ, Sun JH, Simpkins JW, Zhang L, Yuan D, Alkaloids from the hook-bearing branch of Uncariarhynchophylla and their neuroprotective effects against glutamate-induced HT22 cell death. J Asian Nat Prod Res. 2014; 16(8):876-83.
  • Chen F, Qi W, Sun J, Simpkins JW, Yuan D, Urinary Metabolites of Isorhynchophylline in Rats and their neuroprotective activities in the HT22 cell assay. Fitoterapia. 2014 Sep; 97:156-63.
  • Barr, Taura L. and Simpkins, James W., Ischemic Stroke: A Consequence of a Diseased Immune System? Journal of Aging and Disease 5: 292-293, 2014.
  • Ashley B. Petrone; James W. Simpkins and Taura L. Barr, Estrogens and Inflammation: Implications for Ischemic Stroke, Journal of Aging and Disease 5: 340-345, 2014.
  • Qi, W. F. Chen, J. Sun, J.W. Simpkins and D. Yuan, isolation and identification of twelve metabolites of isocorynoxeine in rat urine and their neuroprotective activities in HT22 cell assay, Planta Med 80: 1-10, 2014.

[2013]

  • Simpkins, JW, TE Richardson, KD YI, E Perez, and DF Covey, Neuroprotection with non-feminizing estrogens, Hormones and Behavior 63: 278-283, 2013.
  • Li W, Winters A, Poteet E, Ryou MG, Lin S, Hao S, Wu Z, Yuan F, Hatanpaa KJ, Simpkins JW, Yang SH. Involvement of estrogen receptor β5 in the progression of glioma. Brain Res. 2013 29: 1503: 97-105, 2013.
  • Lincoln KM, Gonzales, P, TE Richardson, DA Julovich, R Saunders, JW Simpkins, KN Green, A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders, ChemComm 49:2712-2714,
  • Timothy E. Richardson, Heather N. Kelly, Amanda E. Yu, and James W. Simpkins. Therapeutic Strategies in Friedreich’s Ataxia, Brain Research 1514: 91-97, 2013.
  • Singh, M, JW Simpkins, H. Bimonte-Nelson and R.D. Brinton, Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer’s disease, Brain Research 1541: 1-2, 2013.
  • Li W, Huang RQ, Shetty RA, Thangthaeng N, Liu R, Chen Z, Sumien N, Rutledge, Dillon GH, Forster MJ, Simpkins JW, Yang SH. Transient focal cerebral ischemia induced long-term cognitive function deficit in an experimental ischemic stroke model. Neurobiology of Disease 59: 18-25, 2013.

[2012]

  • Marianna E. Jung, Xiaohua Ju, Daniel B. Metzger, James W. Simpkins, Ethanol withdrawal hastens the aging of cytochrome c oxidase, Neurobiol Aging 33: 618.21-32,  2012.
  • Luedtke RR, E Perez, S-H Yang, R Liu, S Vanveravong, Z Tu, RH. Mach, JW Simpkins, Neuroprotective Effects of Selective, High Affinity Sigma 1 Receptor Antagonists, Brain Research 1441: 17-26, 2012.
  • Nixon, E and JW Simpkins, Neuroprotective effects of non-feminizing estrogens in retinal photoreceptor neurons, Invest Ophthalmol Vis Sci. 2012 Jul 12; 53(8):4739-47. 2012 Jun 14. [Epub ahead of print]
  • Charles B. Breckenridge, J. Charles Eldridge, James T. Stevens and James W. Simpkins, Symmetrical Triazine Herbicides, Handbook of Pesticide Toxicology, 2nd Edition, In Press, 2012.
  • W. Gatson, Ming-Mei Liu, K. Abdelfattah, J.W. Simpkins, S. Smith, S. Wolf, J.G. Wigginton, J.P. Minei, Estrone is Neuroprotective in Rats Following Traumatic Brain Injury, J Neurotrauma 29: 2209-2219, 2012. Epub 2012 May 8.
  • Richardson TE, Amanda E. Yu, Yi Wen, Shao-Hua Yang and James W. Simpkins, Estrogen Prevents Oxidative Damage to the Mitochondria in Friedreich’s Ataxia Skin Fibroblasts, PloS One, 2012: 7(4) e34600
  • Simpkins, JW, M Singh, C Brock and AM Etgen, Neuroprotection and estrogen receptors, Neuroendocrinology 96: 119-130.
  • Richardson, TE and JW Simpkins, Friedreich’s Ataxia: Disease Progression and the Case for Estrogen Therapy, Current Trends in Endocrinology 6: 1-7, 2012.
  • Kimberly M. Lincoln, Timothy E. Richardson, Lauren Rutter, Paulina Gonzalez, James W. Simpkins and Kayla N. Green, An N-heterocyclic amine chelate capable of anti-oxidant capacity and amyloid disaggregation, ACS Neuroscience 3: 919-927, 2012.
  • Poteet, E. A. Winters, K. Shufelt, K. A. Green,J.W. Simpkins, Y. Wen and S.H. Yang, Cytoprotective actions of methylene blue and its derivatives, PloS One 2012;7(10):e48279.
  • Richardson, TE and JW Simpkins, R- and S-Equol Have Equivalent Cytoprotective Effects in Friedreich’s Ataxia, BCM PharmacologyBMC 2012 Oct 22;13:12.

[2011]

  • Marianna E. Jung, Xiaohua Ju, James W. Simpkins, Daniel B. Metzger, Liang-Jun Yan, Yi Wen, Ethanol withdrawal acts as an age-specific stressor to activate cerebellar P38 kinase, Neurobiology of Aging 2011 Dec;32(12):2266-78.
  • Nguyen, H. P., Li Li, Joshua W. Gatson, David Maass, Jane G. Wigginton, James W. Simpkins, Kevin A. Schug, Simultaneous quantification of four native estrogen hormones at trace levels in human cerebrospinal fluid using liquid chromatography-tandem mass spectrometry, Pharm Biomed. Anal. 54: 830-837, 2011.
  • Gatson, J. W., J.W. Simpkins, K.D. Yi, A. H. Idris, J. P. Minei, J. G. Wigginton, Aromatase is Increased in Astrocytes in the Presence of Elevated Pressure, Endocrinology 152: 207-213, 2011. Epub 2010 Nov 3.PMID: 21047944 21047944
  • Logan SM, Sarkar SN, Zhang Z, Simpkins JW, Estrogen-induced Signaling Attenuates Soluble Aβ Peptide-Mediated Dysfunction of Pathways in Synaptic Plasticity. Brain Res 1383:1-12, 2011.
  • Yi, K.D., E. Perez, S.-H. Yang, R. Liu, D.L. Covey and J.W. Simpkins, The assessment of non-feminizing estrogens for use in neuroprotection, Brain Research Reviews 1379: 61-70, 2011. [Epub ahead of print].
  • Walf AA, Paris JJ, Rhodes ME, Simpkins JW, Frye CA. Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues. Brain Res 1379:119-36, 2011. [Epub ahead of print].
  • Simpkins JW, Yi KD, Perez E, Covey DF. Structure-Nongenomic Neuroprotection Relationship of Estrogens and Estrogen-Derived Compounds. Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis.  Eds AG Gravanis and SH Mellon, Wiley Publishers, Pages 13-28, 2011.
  • Hien Nguyen, Lauren Tedmon, Li Li, Jane G. Wigginton, David Maass, Joshua W. Gatson, James W. Simpkins, Kevin A. Schug, Investigation of the Temperature Stability of Premarin Intravenous using Liquid Chromatography – Mass Spectrometry, Journal of Pharmaceutical and Biomedical Analysis J Pharm Biomed Anal. 55: 1218-1222, 2011.
  • Wen Y, Li W, Poteet E, Xie L, Tan C, Yan, L, Glodberg M, Marvin M, Simpkins JW, Yang SH. Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection. Biol. Chem. 2011 286: 16504-16515.
  • Richardson TE, Yang SH, Wen Y, Simpkins JW, Estrogen Protection in Friedreich's Ataxia Skin Fibroblasts. Endocrinology 152: 2742-2749, 2011. Epub 2011 May 3. PMID: 21540287 [PubMed - in process]
  • Simpkins JW, Swenberg JS, Weiss N, Brusick D, Eldridge JC, Stevens JT, Handa RJ, Hovey RC, Plant TM, Pastoor TP, Breckenridge CB. Atrazine and breast cancer: A framework assessment of the toxicological and epidemiological evidence. Toxicol Sci. 123:441-459, 2011 PMID: 21768606
  • Jung ME, Ju X, Simpkins JW, Metzger DB, Yan LJ, Wen Y , Ethanol withdrawal acts as an age-specific stressor to activate cerebellar p38 kinase. Neurobiol Aging 32: 2266-227, 2011.

[2010]

  • Simpkins, J.W., Your aging defense: Biomarkers of oxidative stress, LifeMap Magazine, 1: 10-11, 2010.
  • Liu R, Liu Q, He S, Simpkins JW, Yang S., Combination therapy of 17{beta}-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. J Pharmacol Exp Ther. 332: 1006-1012, 2010.
  • Simpkins JW, Yi KD, Yang SH, Dykens JA., Mitochondrial mechanisms of estrogen neuroprotection. Biochim Biophys Acta. 1800: 1113-1120, 2010.
  • Hien P. Nguyen, Samuel H. Yang, Jane G. Wigginton, James W. Simpkins, Kevin A. Schug, Retention behavior of estrogen compounds on hydrophilic interaction chromatography stationary phases coupled with electrospray ionization mass spectrometry (HILIC-ESI-MS), Journal of Separation Science 33, 793–802, 2010.
  • Zhang Z. and J.W. Simpkins, Okadaic acid induces tau phosphorylation in SH-SY-5Y cells in an estrogen-preventable manner, Brain Res. 23: 1345:176-181, 2010.
  • Zhang Zhang and James W. Simpkins, An okadaic acid induced model of tauopathy and cognitive deficiency, Brain Res. 1359: 233-246, 2010.
  • Sarkar, S. L. N Smith, S. Logan, and J.W. Simpkins, Estrogen-Induced Activation of Extracellular Signal-Regulated Kinase (ERK) Signaling Triggers Dendritic Resident mRNA Translation, Neuroscience 170: 1080-1085, 2010.
  • Xie L, Poteet EC, Li W, Scott AE, Liu R, Wen Y, Ghorpade A, Simpkins JW, Yang SH., Modulation of polymorphonuclear neutrophil functions by astrocytes. J Neuroinflammation. 2010 Sep 9;7:53. doi: 10.1186/1742-2094-7-53.
  • James W. Simpkins, Brian J. Balin, and Brian E. Wood, Alzheimer’s Disease: The Crisis in Upon Us, American Osteopathic Association 110: S1-S3, 2010.
  • Gerard ILL-Raga, Eva Ramos-Fernández, Francesc X. Guix, Marta Tajes, Mònica Bosch, Ernest Palomer, Juan Godoy, Sebastián Belmar, Waldo Cerpa, James W. Simpkins, Nibaldo C. Inestrosa, and Francisco J. Muñoz, Amyloid ß-peptide fibrils induce nitro-oxidative stress in neuronal cells, J Alzheimers Dis. 22: 641-652,

 [2009]

  • James W. Simpkins, Evelyn Perez, X. Wang, ShaoHua Yang, Yi Wen and Meharvan Singh, The Potential for Estrogens in Preventing Alzheimer’s Disease, Therapeutic Advances in Neurological Disorders 2: 31-49, 2009.
  • James W. Simpkins, Joshua W. Gatson, and Jane G. Wigginton, Rationale and Recommendations for First Evaluating Anti-Alzheimer’s Medications in Acute Brain Injury Patients, Alzheimer’s and Dementia 5: 143-146, 2009.
  • Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA, Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS, Albert MS, Egge R, Deves A, Ferris S, Greenberg BD, Johnson C, Kukull WA, Poirier J, Schenk D, Thies W, Gauthier S, Gilman S, Bernick C, Cummings JL, Fillit H, Grundman M, Kaye J, Mucke L, Reisberg B, Sano M, Pickeral O, Petersen RC, Mohs RC, Carrillo M, Corey-Bloom JP, Foster NL, Jacobsen S, Lee V, Potter WZ, Sabbagh MN, Salmon D, Trojanowski JQ, Wexler N, Bain LJ. A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimers Dement 5: 85-92, 2009.
  • Anna Ratka, Vanessa Miller, Kimberly Brown, Monica Jenschke, Evelyn Perez, Atul Rautand, James W. Simpkins, Association of Various Dimensions of Hot Flashes with Systemic Levels of Gonadal Steroids, Experimental Biology and Medicine 234: 395-402, 2009.
  • James W. Simpkins, Evelyn Perez, X. Wang, ShaoHua Yang, Yi Wen and Meharvan Singh, The Potential for Estrogens in Preventing Alzheimer’s Disease, Therapeutic Advances in Neurological Disorders 2: 31-49, 2009.
  • Shao-Hua Yang, Saumyendra N. Sarkar, Ran Liu, Evelyn Perez, Xiaofei Wang, James W. Simpkins Estrogen receptor beta is a mitochondrial vulnerability factor, J Biol Chem 284: 9540-9548, 2009.
  • Prokai-Tatrai, K., L. Proka, James W. Simpkins and Marianna E. Jung, Phenolic compounds protect cultured hippocampal neurons against ethanol-induced oxidative stress, J. Mol. Sci. 10: 1773-1787, 2009.
  • James W. Simpkins, Kon Don Yi, and ShaoHua Yang, Role of Protein Phosphatases and Mitochondria in the Neuroprotective Effects of Estrogens, Frontiers in Neuroendocrinology, 30: 93-105, 2009.
  • James W. Simpkins, Commentary on “Alzheimer’s disease drug discovery and the problem of the blood-brain barrier”, Alzheimer’s & Dementia 5:433-4, 2009.
  • James W. Simpkins, Kimberly Brown, Sejong Bae and Anna Ratka, Role of Ethnicity in the Expression of Features of Hot Flashes, Maturatis 63: 341-446, 2009
  • Gatson, J. W., D. L. Maass, J.W. Simpkins, A. H. Idris, J. P. Minei, J. G. Wigginton, Estrogen Treatment Following Severe Burn Injury Reduces Brain Inflammation and Apoptotic Signaling, Submitted to the Journal of Neuroinflammation, 6: 1-10, 2009.

[2008]

  • Arti B. Sharma, Matthew A. Barlow,  Shao-Hua Yang,  James W. Simpkins,  Robert T. Mallet, Pyruvate Enhances Neurological Recovery Following Cardiopulmonary Arrest and Resuscitation, Resuscitation 76:108-119, 2008.
  • Simpkins, J.W. and J. A. Dykens, Mitochondrial mechanisms of estrogen neuroprotection. Brain Research Reviews 57: 421-430, 2008.
  • Singh, M., C. Kyser, N. Sumien, J. W. Simpkins, Estrogens and Progesterone as Neuroprotectants: What animal models teach us, Frontiers in Bioscience, 13:1083-1089. 2008.
  • Prokai-Tatrai K, Perjesi P, Rivera-Portalatin NM, Simpkins JW, Prokai L., Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative. Steroids 73: 280-288, 2008.
  • Yi K D, Zu Yun Cai, Douglas F. Covey, and James W. Simpkins, Receptor-Independent Mechanism for Estrogen Neuroprotection via protein phosphatase preservation and attenuation of persistent ERK1/2 activation, J Pharmacol Exp Ther. 324:1188-1195. 2008.
  • James W. Simpkins and Meharvan Singh, More Than a Decade of Estrogen Neuroprotection, Alzheimer’s & Dementia 4: S131-S136, 2008.
  • Jung, M.E., Yan, L-J., Forster, M.J. and Simpkins, J.W. Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable manner. J Bioenerg Biomembr. 40: 35-44. 2008.
  • Simpkins, J. W., Protecting the brain from aging and insult. Journal of Medical Sciences 1: 29-32, 2008.
  • Jung ME, Simpkins JW, Wilson AM, Downey HF, Mallet RT. Intermittent Hypoxia Conditioning Prevents Behavioral Deficit and Brain Oxidative Stress in Ethanol Withdrawn Rats. J Appl Physiol. 105:510-517, 2008.PMID: 18499779
  • Paul Aisen, Marilyn Albert, John C.S. Breitner, Neil Buckholtz, Jodey P. Corey-Bloom, Jeffrey L. Cummings, Rachelle Doody, Bill Evans, Steven Ferris, Howard Fillit, Norman Foster, Richard A. Frank, Doug Galasko, Serge Gauthier, Sid Gilman, Barry Greenberg, Michael Grundman, Bradley Hyman, Claudia Kawas, Jeffrey Kaye, Ara Khachaturian, Zaven Khachaturian, Edward Koo, Lew Kuller, Richard Mohs, Marcelle Morrison-Bogorad, Ronald C. Petersen, Tony Phelps, Judes Poirier, Barry Reisberg, Marwan Sabbagh, David P. Salmon, Mary Sano, Dale Schenk, Lon S. Schneider, James Simpkins, Peter J. Snyder, Stephen Snyder, Ronald G. Thomas, Jacques Touchon, Mark H. Tuszynski, Bruno Veilas, Michael W. Weiner, Richard J. Wurtman. Reporter: Lisa J. Bain, Preventing Dementia: Following in Leon Thal’s Footsteps, Alzheimer’s & Dementia 4: 156-163, 2008.
  • Kun Don Yi and James W. Simpkins, PP1, PP2A, and Calcineurin Play a Role in Estrogen-mediated Neuroprotection, Endocrinology 149: 5235-5243, 2008.
  • Maneesh Kumar, James W. Simpkins and Neeraj Agarwal, Estrogens as Retinal Neuroprotectants, Molecular Vision 14: 1480-1486, 2008.
  • Pugseevijitprapa, W., G. A. Brazeau, J.W. Simpkins and R. Bodmeier, Myotoxicity studies of O/W-in situ forming microparticle systems, European J Pharmaceutics and Biopharmaceutics, 69: 126-133, 2008.
  • Sarkar, S., R.-Q. Huang, S. Logan, G.H. Dillon and J.W. Simpkins, Estrogens directly potentiate neuronal L-type Ca2 channels, Proceedings of the National Academy of Sciences, USA 105: 15148-15153, 2008.
  • James W. Simpkins, ShaoHua Yang, Saumyendra N. Sarkar and Virginia Pearce, Estrogen Actions on Mitochondria-Physiological and Pathological Implications, Molecular and Cellular Endocrinology 290(1-2):51-59, 2008.
  • Yi KD, Covey DF, Simpkins JW. Mechanism of Okadaic Acid Induced Neuronal Death and the Effect of Estrogens. J Neurochem. 108: 732-740, 2008.
  • Jung ME, Wilson AM, Ju X, Wen Y, Metzger DB, Simpkins JW. Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen preventable manner. J Pharmacol Exp Ther. 328: 692-698, 2008

[2007]

  • Perez, E., X. Wang and J.W. Simpkins, Role of Antioxidant activity of estrogens in their potent neuroprotection, submitted Oxidative Stress and Neurological Disorders, Editor, G. Ali Queshi, Elsevier Publishing Company, Holland, pp 497-518, 2007.
  • Mao, X., S.H. Yang, J.W. Simpkins and S W. Barger, Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons, J Neurochemistry 100: 1300-1314, 2007.
  • Yi Wen, Shaohua Yang, Ran Liu, Evelyn Perez, Anne Marie Brun-Zinkernagel, Peter Koulen and James W. Simpkins Cdk5 is involved in NFT-like tauopathy Induced by Transient Cerebral Ischemia in Female Rats, Biochem Biophysica Acta 1772: 473-383, 2007.
  • Liu, R., H. Yang , J. Cutright, K.D. Yi , X Wang , Y-J Hu, A. L. Day, J. W. Simpkins,   Dose dependence and therapeutic window for the neuroprotective effects of 17 b-estradiol when administered after cerebral ischemia, Neuroscience Letters 415: 237-241, 2007.
  • Jung, M.E., R Agarwal, and J.W. Simpkins, Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner, Neuroscience Letters 416: 160-164, 2007.
  • Prokai, L., and J.W. Simpkins, Structure-non-genomic neuroprotection relationship of estrogens and estrogen-derived compounds, Pharmacology & Therapeutics 114: 1-12, 2007.
  • Simpkins, J.W., Brain Rusting: The Paradox of Life on the Edge" the Kronos Longevity Kronical, 8: 8-10, 2007.
  • Giuseppina Tesco, Young Ho Koh, Eugene Kang, Andrew Cameron, Shinjita Das, Miguel Sena-Esteves, Mikko Hiltunen, Shao-Hua Yang, Zhenyu Zhong, Yong Shen, James W. Simpkins and Rudolph E. Tanzi, Depletion of GGA3 stabilizes BACE and enhances b-secretase activity. Neuron. 54:721-737, 2007.
  • Shao-Hua Yang and James W. Simpkins, Ischemia-Reperfusion Promotes Tau and Beta-Amyloid Pathology and a Progressive Cognitive Impairment, in Ischemia-Reperfusion Pathways in Alzheimer’s Disease, Ed. Ryszard Pluta, Nova Science Publications, pp 113-118, 2007.
  • John A. Schetz, Evelyn Perez, Shiuhwei Chen, Ran Liu and James W. Simpkins, A prototypical sigma-1 receptor antagonist protects against brain ischemia, Brain Research 1181: 1-9, 2007.
  • Mengna Xia, Shaohua Yang, James W. Simpkins, Hanli Liu, Noninvasive Monitoring of Estrogen Effects against Ischemic Stroke in Rats by Near Infrared Spectroscopy, Applied Optics 46: 8315-8321, 2007.
  • Simpkins, J.W., Alzheimer’s Research at the University of North Texas Health Science Center, Generations, November 2007.

[2006]

  • Evelyn Perez, Zu Yun Cai, Douglas F. Covey, James W. Simpkins, Neuroprotective Effects of Estratriene Analogs: Structure-Activity Relationships and Molecular Optimization, Drug Development Research 68: 1-15, 2006.
  • Anna Ratka, Vanessa Miller, Kimberly Brown, Atulkumar Raut, Daisha Cipher, and J.W. Simpkins, Evaluation of the validity, reliability, and sensitivity of a Menopausal Vasomotor Symptoms (MVS) Survey in the Assessment of Hot Flashes, J Women’s Health 15: 77-89, 2006.
  • Singh, M., J.A. Dykens and J.W. Simpkins, Novel Mechanisms for Estrogen-Induced Neuroprotection, J Experimental Biology & Medicine 231: 514-521, 2006.
  • Wang, X, J. A. Dykens, E.J. Perez, R. Liu, S.-H. Yang, D.F. Covey and J.W. Simpkins, Neuroprotective effects of 17b-estradiol and non-feminizing estrogens against H2O2-induced toxicity in human neuroblastoma SK-N-SH cells, Molecular Pharmacology 70:395-404, 2006.
  • Yang, S.H., L. Prokai, and James W. Simpkins, Correspondence regarding Schwend and Gustafsson, "False positives in MALDI-TOF detection of ER beta in mitochondria" Biochemical and Biophysical Research Communications 345: 917-918, 2006.
  • Cheryl D Bushnell, MD, MHS, Patricia Hurn, PhD, Carol Colton, PhD, Virginia Miller, PhD, Gregory del Zoppo, MD, MS, Mitchell Elkind, MD, Barney Stern, MD, David Herrington, MD, Gwendolyn Ford-Lynch, MD, Philip Gorelick, MD, MPH, Andra James, MD, MPH, Candice Brown, PhD, Emily Choi, MD, Paul Bray, MD, L Kristin Newby, MD, MHS, Larry Goldstein, MD and James W. Simpkins, PhD Advancing the Study of Stroke in Women. Summary and Recommendations for Future Research from an NINDS-Sponsored Multidisciplinary Working Group, Stroke 37: 2387-2399, 2006.

[2005]

  • James W. Simpkins, Jian Wang, X. Wang, Evelyn Perez, Laszlo Prokai and James A. Dykens, Mitochondria Play a Central Role in Estrogen-Induced Neuroprotection, Current Drug Targets-CNS and Neurological Disorders, 4:69-83
  • Simpkins, J. W., S.H. Yang, Y. Wen and M. Singh, Neuroprotective Effects of Female Sex Steroids: Animal Studies, Cellular and Molecular Life Science 62: 271-280, 2005.
  • James W. Simpkins, Jian Wang, X. Wang, Evelyn Perez, Laszlo Prokai and James A. Dykens, Mitochondria Play a Central Role in Estrogen-Induced Neuroprotection, Current Drug Targets-CNS and Neurological Disorders, 4:69-83, 2005.
  • Jung, M. E., M. B. Gatch and J. W. Simpkins, Estrogen Neuroprotection Against the Neurotoxic Effects of Ethanol Withdrawal: Potential Mechanisms, Experimental Biology & Medicine 230: 8-22, 2005.
  • James W. Simpkins, ShaoHua Yang, and Yi Wen, Use of Estrogens as Neuroprotectants in Stroke and Alzheimer’s Disease, In Synaptic Plasticity: From Basic Mechanisms to Clinical Application, Eds. M. Baudry, A. Bi and S. S. Schreiber, Marcel Dekker, Inc., New York, pp 175-188, 2005.
  • Simpkins, J. W., S.H. Yang, Y. Wen and M. Singh, Estrogens, progestins, menopause and neurodegeneration: basic and clinical studies, Cellular and Molecular Life Science 62: 271-280, 2005.
  • Rewal, M., Y. Wen, J. W. Simpkins and M.E. Jung, Ethanol withdrawal reduces cerebellar parvalbumin expression in a manner reversed by estrogens, Neuroscience Letters 377: 44-48, 2005.
  • Kumar, D. M., Paul Aoun, Evelyn Perez, Ann Marie-Brun Zinkernagel, James W. Simpkins and Neeraj Agarwal, Role of Nonfeminizing Estrogen Analogues in Neuroprotection of Rat Retinal Ganglion Cells against Glutamate-Induced Cytotoxicity, Free Radical Biol Med 38: 1152-1163, 2005.
  • Shao-Hua Yang, Ran Liu, Evelyn J. Perez, Xiaofei Wang, James W. Simpkins. Estrogens as protectants of the neurovascular unit against ischemic stroke, Current Drug Targets 4: 169-177, 2005.
  • Perez, E., R. Liu, S.H. Yang, Z.Y. Cai, D. F. Covey and James W. Simpkins, Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo, Brain Research 1038:216-222, 2005.
  • Simpkins, James W. and R. Van Meter, Potential Testosterone Therapy for Hypogonadal Sexual Dysfunction in Women. Journal of Women’s Health 14: 428-430, 2005.
  • Jung, M., D. G. Watson, S. Jacobs, M. Rewal and J. W. Simpkins, Estrogen inhibits cellular distribution of protein kinase C€ in a binge model of ethanol dependence and withdrawal, European J Pharmacology 515: 62-72, 2005.
  • James W. Simpkins, Yi Wen, Evelyn Perez, ShaoHua Yang, and Xiaofei Wang, Role of Non-feminizing Estrogens in Brain Protection from Cerebral Ischemia: An Animal Model of Alzheimer’s Disease Neuropathology, New York Academy of Science 1052: 233-242, 2005.
  • Yi, K. D., J. C. Gwon, P.Pang and James W. Simpkins, Role of Protein Phosphatases in Estrogen-Mediated Neuroprotection, Neuroscience 25: 7191-7198, 2005.
  • Yi Wen, Shaohua Yang, Ran Liu, Saumyendra Sarkar and James W. Simpkins, Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats, FABS Letters 579: 4591-4599, 2005.
  • Zhen He; Li Cui, PhD; James Meschia; Dennis W. Dickson; Thomas G. Brott; James W. Simpkins; Arthur L. Day, Michael McKinney, Hippocampal progenitor cells express nestin following ischemia in rats, NeuroReport 16: 1541-1544, 2005.
  • Rewal, M., Y. Wen, A Wilson, J. W. Simpkins, and M.E. Jung, Role of Paralbumin in estrogen protection from ethanol withdrawal syndromes, Alcoholism: Clinical and Experimental Research 10: 1837-1844, 2005.
  • Ran Liu, Yi Wen, Evelyn Perez,  Xiaofei Wang,  Arthur L. Day, James W. Simpkins, Shao-Hua Yang, 17 β-Estradiol Attenuates Blood-Brain Barrier Disruption Through by Cerebral Ischemia-Reperfusion Injury in Female Rats, Brain Research 1060: 55-61, 2005.
  • Jung, M.E., D.G. Watson and J. W. Simpkins, Suppression of Protein Kinase Ce mediates 17b-estradiol-induced neuroprotection in an immortalized cell line J. Neurochemistry 745-755, 2005.

[2004]

  • Shao-Hua Yang, Ran Liu, Samuel S. Wu, James W. Simpkins, The Use of Estrogens and Related Compounds in the Treatment of Damage from Cerebral Ischemia, In Steroids and the Nervous System, Annuals of the New York Academy of Sciences 1007: 101-107, 2004.
  • Cammarata, P. R., S. Chu, A. Moor, S.-H. Yang and J. W. Simpkins, Subcellular distribution of native estrogen receptors α and β in cultured human lens epithelial cells, Investigational Eye Research 78: 861-871, 2004.
  • Yang, S. H., J. Wang and J. W. Simpkins, Novel strategies for neuroprotection against Acute Brain Damage, in A Textbook on Neurointensive Care, Eds. A. J. Layon, A. Gabrielle and W. A. Friedman, W. B. Saunders Company, pp 849-863, 2004.
  • Shao-Hua Yang; Ran Liu; Stanley M. Stevens, Jr.; Thomas Valencia, Yi Wen, Anne-Marie Brun-Zinkernagel; Laszlo Prokai; Yvonne Will, James Dykens; Peter Koulen, James W. Simpkins, Mitochondrial localization of estrogen receptor beta, National Academy of Sciences USA, 101: 4130-4135, 2004.
  • Yi Wen, Otuonye Onyewuchi, Shaohua Yang, Ran Liu, and James W. Simpkins, Increased b-Secretase Activity and Expression in Rats Following Transient Cerebral Ischemia, Brain Research 1009: 1-8, 2004.
  • Wen, Y., S.-H. Yang, R. Liu, E. J. Perez, K. D. Yi, P. Koulen and J. W. Simpkins, Estrogen attenuates post-ischemic and nuclear factor-kappa B activation induced by transient cerebral ischemia, Brain Research 1008: 147-154, 2004.
  • Wen, Y. , S.H. Yang, R. Liu, A. M. Brun-Zinkernagel , P. Koulen and J. W. Simpkins, Transient cerebral ischemia induces aberrant neuronal cell cycle reentry and Alzheimer’s disease-like tauopathy in female rats, Journal of Biological Chemistry 279: 22684-22692, 2004.
  • Wen, Y., E. J. Perez, P.S. Green and J. W. Simpkins, nNOS mediates neuroprotective effects of 17 b-estradiol in neuroblastoma cells, NeuroReport 15: 1515-1518, 2004.
  • Jung, M. E, M. Rewal, E. Perez and j. W. Simpkins, Estrogen protects against brain lipid peroxidation in ethanol withdrawn rats. Pharmacology, Biochemistry & Behavior 79: 573-586, 2004.
  • Rewal, M. M.E. Jung and James W. Simpkins, Role of the GABA-A system in estrogen-induced protection against brain lipid peroxidation in ethanol-withdrawn rats, Alcohol: Clinical and Experimental Research, Alcohol Clin Exp Res. 28:1907-1915, 2004.
  • Simpkins J. W. and M. Singh for the CAPRE Group, Consortium for the Assessment of Research on Progestins and Estrogens (CARPE), J. Women’s Health 13: 1165-1168, 2004.
  • Wen, Y., S.H. Yang, R. Liu and J. W. Simpkins, Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein, Brain Research 1022, 30-38, 2004.
  • Simpkins, J.W., S.H. Yang, R. Liu, E. Perez, Z.Y.Cai, D.F. Covey and P.S. Green, estrogen-like compounds for ischemic neuroprotection. Stroke 35 (Suppl. 1) 2648-2651, 2004.
  • Zhen He, MD, Li Cui, MD, Samuel S. Wu, Xiao-Yong Li, James W. Simpkins, Arthur L. Day, and Michael McKinney, Increased severity of acute cerebral ischemic injury correlates with enhanced stem cell induction as well as with predictive behavioral profiling. Current Neurovascular Research 1: 399-409, 2004.
  • Shao-Hua Yang, Ran Liu, Samuel S. Wu, James W. Simpkins, The Use of Estrogens and Related Compounds in the Treatment of Damage from Cerebral Ischemia, In Steroids and the Nervous System, Annuals of the New York Academy of Sciences 1007: 101-108, 2004.
  • Yang, S.H., R. Liu, Y. Wen, E. Perez, J. Cutright, A.M Brun-Zinkernagel, M.Singh, A.L. Day and J.W. Simpkins, Neuroendocrine mechanism for tolerance to cerebral ischemia-reperfusion injury in male rats, J. Neurobiology 62: 341-351, 2004.

[2003]

  • Dykens, J.A., J.W. Simpkins, J. Wang and K. Gordon, Polyphenolic Steroids and Neuroprotection: A proposed mitochondrial Mechanism, Experimental Gerontology 38: 101-107, 2003.
  • Wang, X., J.  W. Simpkins, J. A. Dykens and P. R. Cammarata, Effects of estrogens against oxidative damage to human lens epithelial cells in culture. Part 1. Protection of mitochondria; potential, intracellular ATP and cell viability, Investigative Ophthalmology & Visual Science 44: 2067-2075, 2003.
  • Kaja, S., S.H. Yang, J. Wei, K. Fujitani, R. Liu, A.M Brun-Zingernagel, J. W. Simpkins, K. Inokucki and P. Koulen, Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections. Investigative Ophthalmology & Visual Science 44: 3155-3162, 2003.
  • Aoun, P., J.W. Simpkins, N. Agarwal, PPAR-g ligands are neuroprotective against glutamate induced cytotoxicity in retinal ganglion cells, Investigative Ophthalmology & Visual Science 44:2999-3004, 2003.
  • Aoun, P. and J. W. Simpkins, Neuroprotective effects of PPARg agonists against oxidative insults in HT-22 cells, European J. Pharmacology 472: 65-71, 2003.
  • Prokai, , K. Prokai-Tatrai, P. Perjesi, A. Zharikova and J. W. Simpkins, Quinol-based bioreversible metabolic cycle for estrogens in rat liver microsomes, Drug Metabolism and Deposition 31: 701-704 2003.
  • Prokai, L., K. Prokai-Tatrai, P. Perjesi, A. Zharikova, E. Perez, R. Liu and J.W. Simpkins, Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection. Proc. National Academy of Sciences USA 100: 11741-11746, 2003.
  • Rewal, M., M. E. Jung, Y. Wen, A.-M. Brun-Zinkernagel and J. W. Simpkins, Role of the GABA-A System in behavioral, motoric and cerebellar protection by estrogen during ethanol withdrawal, Alcohol 31: 49-61,2003.
  • Jung, M. E., D. G. Watson, Y. Wen and W. Simpkins, Role of protein kinase C in estrogen protection against apoptotic cerebellar cell death in ethanol withdrawn rats, Alcohol 31: 39-48, 2003.
  • Fan, T. S.H. Yang, E. Johnson, B. Osteen, R. Hayes, A. L. Day and W. Simpkins, 17ß-estradiol can extend ischemic thresholds and exert neuroprotective effects in cerebral subcortex against transient focal ischemia in rats, Brain Research 993: 10-17, 2003.

[2002]

  • Duff, K., S. Petanceska, X. Yu, R. Wang, S. Uljon, B. Malester, M. Picciano, J.W. Simpkins and L.M. Refolo, Enhanced amyloidosis in response to ovariectomy in a transgenic model of Alzheimer’s disease, Neurochemistry 80:191-196, 2002.
  • Yang, S.-H., E. Perez, J. Cutright, R. Liu, Z.He, A. L. Day and J. W. Simpkins, Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model. J. Applied Physiol. 92: 195-201, 2002.
  • He, Z. Yun-Ju He, Arthur L Day, and James W Simpkins, Proestrus levels of estradiol during transient cerebral ischemia improve histological outcome of the hippocampal CA 1 region: perfusion-dependent and –independent mechanisms. Journal of the Neurological Sciences, 193: 79-87, 2002.
  • Jung, M. E., S.H. Yang, A. M. Brun-Zinkernagel and J. W. Simpkins, Estradiol protects against ethanol withdrawal-induced cerebellar and motor deficit, Alcohol 26: 83-93, 2002.
  • Liu, R. S. H. Yang, E. Perez, K. D. Yi, S. S. Wu, K. Eberst, L. Prokai, K. Prokai-Tatrai, Z.Y. Cai, D. F. Covey A. L. Day and J. W. Simpkins, Neuroprotective effects of a novel non-receptor binding estrogen analogue: In vitro and in vivo analysis, Stroke 33: 2485-2491, 2002.

[2001]

  • Shi, J., J.D. Bui, S.H. Yang, T.H. Lucas, D. L. Buckley. S.P. Blackband, M.A. King, A.L. Day and J.W. Simpkins, Estrogens decrease reperfusion-associated cortical ischemic damage: a MRI analysis in a transient focal ischemia model. Stroke, 32:987-992, 2001.
  • Stevens, J. T., C. B. Breckenridge, J.W  Simpkins, and J.C. Eldridge, Symmetrical and Asymmetrical Triazine Herbicides, In Handbook of Pesticides Toxicology, Volume 2, pp.  1511-1519, 2001.
  • Green, P.S., S.H.Yang, K.R. Nilsson, A.S. Kumar, D.F. Covey, and J.W. Simpkins, The Nonfeminizing Enantiomer of 17α-Estradiol Exerts Protective Effects in Neuronal Cultures and a Rat Model of Cerebral Ischemia. Endocrinology,  142: 400-406, 2001
  • Prokai, L., S-M Oon, K. Prokai-Tatrai, K.A. Khalil and J.W. Simpkins, Synthesis and Biological Evaluation of 17 $-alkoxyestra-1,3,5(10)-trienes:Potential Neuroprotectants Against Oxidative Stress,  J.Med. Chemistry , 44: 110-114, 2001
  • Wang, J., P.S. Green and J.W. Simpkins, Estradiol Protects Against ATP Depletion, Mitochondrial Membrane Potential Decline and the Generation of Reactive Species by 3-nitropropionic Acid in SK-N-SH Human Neuroblastoma Cells, J. Neurochem. 77: 804-811, 2001.
  • He, Z., T. Yamawaki, S.-H. Yang, Q. Liu, M.A King, A.L. Day, J.W. Simpkins, and H. Naritomi, Definition of the anterior choroidal artery territory in rats using intraluminal technique, J. Neurological Sciences 182: 16-28, 2001.
  • Prokai, L, S-M Oon, K. Prokai-Tatrai, K. A. Khalil and J. W. Simpkins, Synthesis and biological evaluation of 17 b-alkoxyestra-1,3,5(10)-trienes: potential neuroprotectants against oxidative stress, J. Med. Chemistry, 44: 110-114, 2001.
  • Yang, S.-H., Z He, S. S. Wu, Y.-J. He, J. Cutright, W.J. Millard, A. L .Day, and J.W. Simpkins, 17 b-estradiol can reduce secondary ischemic damage and mortality of subarachnoid hemorrhage, J Cerebral Blood Flow and Metab. 21: 174-181, 2001.
  • Liang, Y., S. Belford, F. Tang, L. Prokai, J. W. Simpkins and J. A. Hughes, Membrane fluidity effects if estratrienes, Brain Res Bull. 54:61-668, 2001.

[2000]

  • Simpkins, J. W. and Green, P.S., Estrogens: Pleiotropic anti-Alzheimer’s disease therapy. In “Promising Directions of Research and New Therapeutic Targets for the treatment of Alzheimer'’ Disease”, Eds. M. Mesulam and Z. S. Khachaturian, 2000.
  • Simpkins, J. W.,S. Green, K.E. Gridley, J. Shi, E. M. Monck, Neuroprotective Effects of Estrogens, in “Biology of the Menopause”, Ed. F.L. Bellino, Serono Symposium, Springer-Verlag, New York, pp  103-111, 2000.
  • Persky, A.M., P.S. Green, L.A. Stubley, C.S. Howell, L. Zaulyanov, G.A. Brazeau and W. Simpkins, Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro. Proc Soc Expt Biol Med, 223: 59-66, 2000.
  • Shi, J., S.H. Yang, A.L. Day and J.W. Simpkins, Hypoperfusion induces over-expression of -amyloid precursor protein mRNA in a focal ischemia rodent model. Brain Res, 853: 1-4, 2000
  • Green, P.S., S. -H. Yang and J.W. Simpkins, Neuroprotective Effects of Phenolic A Ring Estrogens, Novartis Foundation Symposium “Neuronal and Cognitive Effects of Oestrogens” Eds. J. Goode and B. McEwen, pp 202-220, 2000.
  • Green, P.S. and J. W. Simpkins, Neuroprotective effects of estrogens: potential mechanisms of action, J Developmental Neuroscience, 18: 347-358, 2000.
  • Simpkins, J. W., The Role of Estrogen replacement therapy in the prevention of neurodegeneration associated with Alzheimer’s disease and stroke, Response to an Aging Florida, Spring, 2000.
  • Green, P.S. and J. W. Simpkins, Role of estrogens and estrogen-like non-feminizing compounds in the prevention and treatment of Alzheimer’s disease, Annals of the New York Academy of Sciences, 924: 93-98, 2000.
  • Green, P.S., E.J. Perez, T. Calloway, and W. Simpkins, Estradiol attenuation of b-amyloid-induced toxicity: A comparison of MTT and Calcein assays, J. Neurocytology 29: 419-423, 2000.
  • Yang, S.H., A. L. Day and J. W. Simpkins, Estradiol exerts neuroprotective effects when administrated after ischemic insult. Stroke 31: 745-749, 2000.
  • Simpkins, J. W.,S. Green, K.E. Gridley, J. Shi, E. M. Monck, Neuroprotective Effects of Estrogens, in “Biology of the Menopause”, Ed. F. L. Bellino, Serono Symposium, Springer-Verlag, New York, pp. 103-111, 2000.
  • Simpkins, J. W. and Green, P.S., Estrogens: Pleiotropic anti-Alzheimer’s disease therapy. In “Toward a comprehensive Theory for Alzheimer’s Disease”, Eds. M. Mesulam and Z. S. Khachaturian, 2000, pp. 33-40.

[1999]

  • Zaulyanov, L. L., P.S. Green and J. W. Simpkins. Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: An in vitro model for assessment of the neuroprotective effects of estrogens.  Cell. Mol. Neurobiol. 6:705-718, 1999.
  • Eldridgh, CJ.C. L.T. Wetzel, J. T. Stevens and James W. Simpkins, The mammary tumor response to triazine-treated female rats: a threshold-mediated interaction with strain and species-specific reproductive senescence. Steroids 64: 672-678, 1999.
  • He, Z., H. Naritomi, S. H. Yang, T. Yamawaki, A.L. Day, and J. W. Simpkins, An experimental model of a small deep infarct involving the hypothalamus in rats: changes in body temperature and postural reflex. Stroke, 30: 2743-2751, 1999.
  • Devane, C.L., J.W. Simpkins, D.W. Boulton, S.C. Laizure and R.L. Miller, Disposition of morphine in tissues of the pregnant rats and fetus following intraperitoneal administration to the mother, J Pharm Pharmacol, 51: 1283-1287, 1999.
  • Persky, A. M., G. A. Brazeau and J. W. Simpkins, Therapeutic benefits of estrogen replacement therapy, Florida Pharmacy J, December, 1999, pp. 14-20.
  • Wang, W., P.S. Ajamni, E. M. Meyer, J. W. Simpkins and J. A. Hughes, Pre-exposure of cells to cationic lipids enhances transgene delivery and expression in a tissue culture cell line, J Drug Targeting 7: 207-211, 1999.

[1998]

  • Simpkins, J.W., C. Eldridge, M.O. Tisdel and L.T. Wetzel. Role of strain-specific reproductive patterns in the appearance of mammary tumors in atrazine-trated female rats. In Triazine Herbicides:  Risk Assessment, American Chemical Society Books, Eds, L. Ballantine, J. McFarland and D. Hackett, 1998, pp. 399-413.
  • Prokai, L., X. Ouyang, K. Prokai-Tatrai, and J. W. Simpkins and N. Bodor. Synthesis and behavioral evaluation of a chemical brain-targeting system for a thyrotropin-releasing hormone analogue.  Eur. J. Med. Chem.  33:879-886, 1998.
  • Green, P.S., K.E. Gridley, and J. W. Simpkins. Nuclear estrogen receptor-independent neuroprotection by estratrienes: A novel interaction with glutathione.  Neuroscience 84:7-10, 1998.
  • Zhang, Y.Q., J. Shi, G. Rajakumar, A.L. Day, and J. W. Simpkins. Effects of gender and estradiol treatment on focal brain ischemia.  Brain Res. 784: 321-324, 1998.
  • Hawk, T., Y-Q Zhang, G. Rajakumar, A.L. Day, and J.W. Simpkins. Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats.  Brain Research 796:296-298, 1998.
  • Panickar, K.S., K. Purushotham, M.A. King, G. Rajakumar and J.W. Simpkins. Hypoglycemia-induces seizure reduce CREB levels in the rat hippocampus and cortex.  Neuroscience 83: 1155 - 1160, 1998.
  • Gridley, K.E., P.S. Green, and J. W. Simpkins. A novel, synergistic interaction between 17 b-Estradiol and glutathione in the protection of neurons against β-Amyloid 25-35-induced toxicity In Vitro.  Molecular Pharmacology, 54:874-880, 1998.
  • Simpkins, J.W., O. Rabbani, J. Shi, K.S. Panickar, P.S. Green, and A.L. Day. A system for the brain-enhanced delivery of estradiol: An assessment of its potential for the treatment of Alzheimer’s disease and stroke.  Die Pharmazie, 53: 505-511, 1998.
  • Prokai, L. K. Prokai-Tatrai, W. M. Wu, J Wu, X. Ouyang, H.S. Kim, A. Zharikova, J.W. Simpkins and N. Bodor, Brain delivery and targeting of thyrotropin-releasing hormone analogs by covalent packaging and sequential metabolism, in Peptides: Frontiers of Peptide Science, Kluwer Academic, Dordrecht, The Netherlands, 1998, pp. 834-836.
  • Shi, J., K. S. Panickar, S. Yang, O. Rabbani, and J. W. Simpkins. Estrogen attenuates over-expression of amyloid precursor protein mRNA in an animal model of focal ischemia.  Brain Research, 810: 87-92, 1998.

[1997]

  • Green, P.S., J. Bishop and J.W. Simpkins. 17 -estradiol exerts neuroprotective effects on SK-N-SH cells.  Journal of Neuroscience, 17: 511-515, 1997.
  • Simpkins, J.W., P.S. Green, K.E. Gridley, M. Singh, N.C. de Fiebre and G. Rajakumar. Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease.  J. Medicine 103:195-255, 1997.
  • Simpkins, J.W., P.S. Green and K.E. Gridley. Fundamental role for estrogens in cognition and neuroprotection.  In Pharmacological Treatment of Alzheimer's disease, Eds. J.D. Brioni and M.W. Decker,  Wiley-Liss, Inc., New York, 1997, pp 503-524.
  • Shi, J. and J.W. Simpkins. 17 β-Estradiol modulation of glucose transporter 1 (GLUT 1) expression in blood-brain barrier.  AJP Endocrinal and Metabolism 272: E1016 - E1022, 1997.
  • Ratka, A. and J.W. Simpkins. LHRH attenuates morphine-induced inhibition of cAMP in opioid-responsive SK-N-SH cells.   Neuropeptides 31: 113-117, 1997.
  • Kourounakis, A., N. Bodor, and J.W. Simpkins. Synthesis and evaluation of brain-targeted chemical delivery systems for the neurotrophomodulator 4-Methylcatetchol.  J. Pharm. Pharmacol 49: 1-9, 1997.
  • Panickar, K.S., G. Guan, M.A. King, G. Rajakumar, and J.W. Simpkins. 17 -Estradiol attenuates CREB decline in the rat hippocampus following seizure.   J. Neurobiology 33: 961-967, 1997.
  • Rabbani, O., K.S. Panickar, G. Rajakumar, M.A. King, N. Bodor, E.M. Meyer, and J.W. Simpkins. 17 b-Estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum.  Exper. Neurology 146: 179-186, 1997.
  • Shi, J., Y Xiang, and J. W. Simpkins. Hypoglycemia enhances the expression of mRNA encoding β-amyloid precursor protein in rat primary cortical astroglial cells.  Brain Research 772: 247-251, 1997.
  • Simpkins, J.W., G. Rajakumar, Y.Q. Zhang, C.E. Simpkins, D. Greenwald, C.H.Yu, N. Bodor, and A.L. Day, Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. Neurosurg 87: 724-730, 1997.
  • Green, P.S., K. Gordon, and J. W. Simpkins. Phenolic A ring requirement for the neuroprotective effects of steroids.  J. Steroid Biochemistry & Molecular Biology 63: 229-235, 1997.
  • Shi, J., Y.Q. Zhang, and J.W. Simpkins. Effects of 17 β-Estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats.  Experimental Brain Res.117:200-206, 1997.
  • Simpkins, J.W.,S. Green, K.E. Gridley, and J. Shi. Estrogens and Memory Protection. Journal SOGC Supplement: 14-20, 1997.
  • Gridley, K.E., P.S. Green, and J. W. Simpkins. Low concentrations of estradiol reduce β-amyloid (25-35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells. Brain Research 778:158-165, 1997.

[1996]

  • Eldridge, J.C., J.T. Stevens, L.T. Wetzel, C.B. Breckenridge, R.F. McConnell and J.W. Simpkins. Atrazine:  mechanism of hormonal imbalance in female Sprague-Dawley rats.  Fund. Appl. Toxicol.  29: 1-17, 1996.
  • Srinivasan, V., D. Wielbo, J.W. Simpkins, J. Karlix, K. Sloan and I. Tebbett. Analgesic and immunomodulatory effects of codeine and codeine-6-glucuronide.  Pharmaceutical Research 13:296-300, 1996.
  • Simpkins, J.W. The role of astrocytes in brain aging: thoughts on the oxidative role of estrogens.  Neurobiology of Aging, 1996.
  • Green, P.S., K.E. Gridley and J.W. Simpkins. Estradiol protects against amyloid-induced toxicity in SK-N-SH cells.  Neuroscience Letters 218: 165-168, 1996.
  • Kourounakis, A., N. Bodor and J.W. Simpkins. Synthesis and evaluation of a brain-targeted catechol derivative as a potential NGF-inducer.  International Journal of Pharmaceutics 141:239-250, 1996.

[1995]

  • Singh, M., E.M. Meyer and J.W. Simpkins. The effect of ovariectomy and estradiol-replacement on brain derived neurotrophic factor mRNA expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.  Endocrinology 136:2320-2324, 1995.
  • Bishop, J. and J.W. Simpkins. Estradiol enhances brain glucose transport and utilization in ovariectomized rats.  Brain Res. Bulletin 36:315-320, 1995.
  • Simpkins, J.W. The potential use of estrogens in the therapy of Alzheimer's disease.  Aging Research and Policy Report, 1995.
  • Simpkins, J.W. Effects of age, reproductive status and ambient temperature on skin temperature regulation in the female rat.  Maturitas 21:97-102, 1995.

[1994]

  • Simpkins, J.W. Effects of Age and Ovarian Steroids on Responses to Opiates in the Female Rat.  Neurobiology of Aging 15:545-552, 1994.
  • Simpkins, J.W. and N. Bodor. The brain-targeted delivery of dopamine using a redox based chemical delivery system, Advanced Drug Delivery Reviews 14(3):243-249, 1994.
  • Simpkins, J.W. Effects of aging on morphine withdrawal in the rat. Experimental Gerontology 29:67-76, 1994.
  • Simpkins, J.W., X. Ouyang, L. Prokai and N. Bodor. Delivery of peptides into the central nervous system by molecular packaging and sequential metabolism as a method to alter neuropeptide activity during aging.  NeuroProtocols 4(3):225-234, 1994.
  • Simpkins, J.W. and N. Bodor. Enhanced delivery of steroids to the brain using a redox-based chemical delivery system.  Neurobiology of Steroids, Methods in Neurosciences 22:23-35, 1994.
  • Singh, M., E.M. Meyer, W.J. Millard and J.W. Simpkins. Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.  Brain Res. 644:305-312, 1994.
  • Bishop, J. and J.W. Simpkins. Estradiol treatment increases viability of glioma and neuroblastoma cells in vitro.  Molecular and Cellular Neuroscience 5:303-308, 1994.
  • Simpkins, J.W., M. Singh and J. Bishop. The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer's disease.  Neurobiology of Aging 15:S195-S197, 1994.

[1993]

  • Simpkins, J.W., W.J. Millard and L.A. Berglund. Effects of chronic stimulation or antagonism of opiate receptors on GH secretion in male and female rats.  Life Sciences 52:1443-1450, 1993.
  • Yoon, S.-H., J.W. Simpkins and N. Bodor. Synthesis and in vitro dopaminergic activity of (2'-aminoethyl)-1-hydroxy-2-pyridone analogues.  Drug Design and Delivery 10:35-44, 1993.
  • Rahimy, M.H., N. Bodor and J.W. Simpkins. Suppression of plasma testosterone and prostate carcinoma size by a redox-based, brain-targeted estrogen delivery system in the rat.  Prostate 23:79-90, 1993.

[1992]

  • DeVane, C.L., J.W. Simpkins, R.L. Miller, L.A. Berglund and S.C. Laizure. Analysis and disposition of morphine in the pregnant rat.  Acta Pharmacol. et. Toxicol. (in press, 1992).
  • Simpkins, J.W. and N. Bodor. Brain-Enhanced Drug Delivery Systems for the Treatment of Dementia, in Alzheimer's Disease: New Treatment Strategies, Ed. Z.S. Khachaturian and J.P. Blass, Marcel Dekker, Inc., New York, pp. 37-56, 1992.
  • Rahimy, M.H., N. Bodor and J.W. Simpkins. Evaluation of a novel redox-based estrogen-chemical delivery system for the brain.  Ed. R. Mechoulam, in Pure and Applied Chemistry/Chemistry International Symposium Book, Oxford England, 1992.
  • Simpkins, J.W.,H. Rahimy and N. Bodor. Enhanced brain delivery of steroids and neurotransmitters.  Proc. 18th Intern. Symposium of Controlled Release of Bioactive Materials, 1992.
  • Singh, M., J.W. Simpkins, M.P. Layden, T.M. Romano and W.J. Millard. Opiate modulation of growth hormone secretion is compromised during the preovulatory LH surge.  Neuroendocrinology 55:214-220, 1992.
  • Simpkins, J.W. and N. Bodor. Brain Targeted Delivery of neurotransmitters:  Use of a Redox Based Chemical Delivery System, In:  The Treatment of Dementias, A New Generation of Progress, Eds. E.M. Meyer, J.W. Simpkins, J. Yamamoto and F.T. Crews, Plenum Press, New York, 1992, pp. 317-332.
  • Simpkins, J.W. Low Estrogen Oral Contraceptive, Pharmacy Power-Pak, 1992.
  • Simpkins, J.W. Effects of haloperidol and prolactin secreting tumors on cerebrospinal fluid concentrations of prolactin in the female rat.  Life Sciences 51:295-301, 1992.
  • Bishop, J. and J.W. Simpkins. Role of estrogens in peripheral and cerebral glucose utilization.  Reviews in the Neurosciences 3:121-137, 1992.
  • Simpkins, J.W. Effects of advancing age on cerebrospinal fluid concentrations of prolactin in the female rat.  Brain Research 382:357-358, 1992.
  • Bodor, N., L. Prokai, W.-M. Wu, H. Farag, S. Jonalagadds, M. Kawamura and J.W. Simpkins. A strategy for delivering peptides into the central nervous system by sequential metabolism.  Science 257:1698-1700, 1992.

[1991]

  • DeVane, C.L., J.W. Simpkins and S.A. Stout. Distribution of phenobarbi­tal and phenytoin in pregnant rats and their fetuses.  Epilepsia 32:250--256, 1991.
  • Rahimy, M.H., N. Bodor and J.W. Simpkins. Prolonged suppression of androgens and androgen-dependent tissues by a brain-enhanced estrogen delivery system in the rat.  J. Biopharmaceutical Research 2:25-43, 1991.
  • Rahimy, M.H., N. Bodor and J.W. Simpkins. Effects of a brain-enhanced estrogen delivery system on tail-skin temperature of the rat:  implications for menopausal hot flush.  Maturitas 13:51-63, 1991.
  • Ganesan, R. and J.W. Simpkins. Role of conditioned taste aversion in the suppression of food intake by estradiol.  Physiology and Behavior 48:647-652, 1991.
  • Ratka, A. and J.W. Simpkins. Effects of estradiol and progesterone on the sensitivity to pain and on morphine-induced antinociception in female rats.  Hormones and Behavior 25:217-228, 1991.
  • Berglund, L.A. and J.W. Simpkins. Luteinizing Hormone-Releasing Hormone (LHRH) alters the effects of morphine in the rat.  Endocrinology 128:2799-2804, 1991.
  • Simpkins, J.W., D. Swager and W.J. Millard. Evaluation of the site of opioid influence on anterior pituitary hormone secretion using a quaternary opiate antagonist.  Neuroendocrinol. 54:384-390, 1991.
  • Rahimy, M.H., W.R. Anderson, M.E. Brewster, N. Bodor and J.W. Simpkins. The effects of a brain-enhanced estradiol delivery system on testosterone and androgen-dependent tissues:  I. Dose-response and Time-course evaluation.  Endocrinology 129:717-725, 1991.
  • Anderson, W.R., M.H. Rahimy, M.E. Brewster, N. Bodor and J.W. Simpkins. The effects of a brain-enhanced estradiol delivery system on testosterone and androgen-dependent tissue:  II.  The role of testosterone.  Endocrinology 129:726-733, 1991.
  • Ratka, A., G. Hochhaus, R.N. Wissler and J.W. Simpkins, CAMP accumulation in opioid sensitive SH-SYSY neuroblastoma cells is modified by estradiol and progesterone. Molecular and Cellular Endocrinology 78:155-162, 1991.
  • Simpkins, J.W. Is the emerging field of biotechnology important to Pharmacy Practice?  The Florida Society of Hospital Pharmacists Digest:  Issues in Pharmacy Practice Vol. 3 (No. 5) Winter, 1990-91.
  • Ganesan, R., T. Romano and J.W. Simpkins. Comparison of morphine tolerance in body temperature and luteinizing hormone secretion.  Physiology and Behavior 50:505-509, 1991.
  • Peris, J., N. Decambre, M.L. Coleman-Hardee and J.W. Simpkins. Estradiol enhances behavioral sensitization to cocaine and amphetamine-stimulated 3H-dopamine release.  Brain Research 566:255-264, 1991.
  • Brewster, M.E., M.S. Hora, J.W. Simpkins and N. Bodor. Use of 2-hydroxypropyl-ß-cyclodextrin as a solubilizing and stabilizing excipient for protein drugs.  Pharmaceutical Research 8:792-795, 1991.
  • Simpkins, J.W. Solubilization of ovine growth hormone with 2-hydroxypropyl-ß-cyclodextrin.  Parenteral Sci. Technol. 45:1-4, 1991.

[1990]

  • Berglund, L.A., W.J. Millard, S.M. Gabriel and J.W. Simpkins. Opiate-thyroid hormone interaction in the regulation of TSH secretion in the rat.  Neuroendocrinology 52:303-308, 1990.
  • Simpkins, J.W., M.H. Rahimy and N. Bodor. A brain-enhanced chemical delivery system for gonadal steroids: impli­cations for neurodegenerative diseases.  In Novel Procedures for the Treatment of Alzheimer's Disease.  E.M. Meyer, J.W. Simpkins and J. Yamamoto.  Plenum Press, pp. 197-212 1990.
  • Brewster, M.E., J.W. Simpkins and N. Bodor. Brain-targeted delivery of estrogens, Reviews in the Neurosciences 2:241-285, 1990.
  • Millard, W.J., T.M. Romano and J.W. Simpkins. Growth hormone and thyrotropin secretory profiles and provocative testing in aged rats.  Neurobiol. Aging 11:229-235, 1990.
  • Ratka, A. and J.W. Simpkins. Dose-dependent effects of chronic treat­ment with estradiol or progesterone on LH secretion in ovariectomized rats.  Endocrine Research Comm. 16:165-184, 1990.
  • Rahimy, M.H., J.W. Simpkins and N. Bodor. Tissue distribution of a brain-enhanced chemical delivery system for estradiol.  Drug Design and Delivery 6:29-40, 1990.
  • Simpkins, J.W.,K. Andreadis, W.J. Millard and M.J. Katovich. The effect of cellular glucoprivation and skin temperature regulation in the rat.  Life Sci. 47:107-115, 1990.
  • Simpkins, J.W., M.J. Katovich and W.J. Millard. Glucose modulation of skin temperature responses during morphine withdrawal in the rat.  Psychopharmacology 102:213-220, 1990.
  • Brewster, M.E., J.W. Simpkins, M.S. Hora and N. Bodor. Application of 2-hydroxypropyl-ß-cyclodextrin to protein stabilization and solubiliza­tion, Proc. of the Fifth International Symposium on Cyclodextrins, Ed. D. Duchene, Additions de Sonte Pub. Co., Peris 1990.
  • Ratka, A. and J.W. Simpkins. A modulatory role of LHRH in nociceptive responses of female rats.  Endocrinology 127:667-673, 1990.
  • Simpkins, J.W. and M.J. Katovich. Hypoglycemia causes hot flushes in animal models.  In Multidisciplinary Perspectives on Menopause, Annuals of the New York Academy of Sciences Vol. 592, M. Flint, F. Kronenberg and W. Utian, New York, 1990, pp. 436-437.
  • Katovich, M.J. and J.W. Simpkins. Effects of hyperglycemia on the development of a flush response in an animal model for the menopausal hot flush.  In Multidisciplinary Perspectives on Menopause, New York Academy of Sciences Vol. 592, Eds. M. Flint, F. Kronenberg and W. Utian, New York, 1990, pp. 433-435.
  • Millard, W.J., T.M. Romano, N. Bodor and J.W. Simpkins. GH secretory dynamics in animals administered gonadal steroids utilizing a chemical delivery system.  Pharmaceutical Res. 7:1011-1018, 1990.
  • Rahimy, M.H., J.W. Simpkins and N. Bodor. Dose and time course evalua­tion of a redox based estradiol-chemical delivery system for the brain.  I.  Tissue Distribution.  Pharmaceutical Res. 7:1061-1067, 1990.
  • Rahimy, M.H., J.W. Simpkins and N. Bodor. Dose and time course evalua­tion of a redox based estradiol-chemical delivery system for the brain.  II. Pharmacodynamic Responses.  Pharmaceutical Res. 7:1007-1012, 1990.

[1989]

  • Simpkins, J.W. and M.J. Katovich. Relationship between blood glucose and hot flushes in women and an animal model, in Thermoregulation:  Research and Clinical Applications, Eds. P. Lomax and E. Schonbaum, Karger, Basel, pp. 1312-1317 1989.
  • Katovich, M.J. and J.W. Simpkins. Further evidence for an animal model for the hot flush, in Thermoregulation:  Research and Clinical Applica­tions, Eds. P. Lomax and E. Schonbaum, Karger, Basel, pp. 1318-1325 1989.
  • Berglund, L.A., W.R. Millington and J.W. Simpkins. Gonadal steroid and chronic morphine treatment do not change the posttranslational process of ß-endorphin in the rat brain.  Life Sciences 44:591-601, 1989.   
  • Simpkins, J.W.,R. Anderson, R. Dawson, Jr. and N. Bodor. Effects of a brain-enhanced chemical delivery system for estradiol on body weight and food intake in intact and ovariectomized rats.  Pharmaceutical Research 6:592-600, 1989.
  • Phelps, C.H., F.H. Gage, J.H. Growdon, F. Hefti, R. Harbaugh, M.V. Johnston, Z.S. Khachaturian, W.C. Mobley, D.L. Price, M. Raskind, J.W. Simpkins, L.J. Thal, and J. Woodcock. Potential use of nerve growth factor to treat Alzheimer's Disease.  Neurobiology of Aging 10:205-207, 1989.
  • Phelps, C.H., F.H. Gage, J.H. Growdon, F. Hefti, R. Harbaugh, M.V. Johnston, Z.S. Khachaturian, W.C. Mobley, D.L. Price, M. Raskind, J.W. Simpkins, L.J. Thal, and J. Woodcock. Potential use of nerve growth factor to treat Alzheimer's disease.  Science 243:11, 1989.
  • Dawson, R., J.W. Simpkins and D. Wallace. Developmental and dose-dependent effects of neonatal monosodium glutamate (MSG) administration to female rats.  Neurotoxicology and Teratology 11:331-337, 1989.           
  • Anderson, W.R., J.W. Simpkins, M.E. Brewster and N. Bodor. Evidence for prolonged suppression of stress-induced release of ACTH and corticoste­rone with a brain-enhanced dexamethasone-redox delivery system.  Neuro­endocrinology 50:9-16, 1989.
  • Rahimy, M.H., N. Bodor and J.W. Simpkins. A rapid, sensitive method for the simultaneous quantitation of estradiol and estradiol conjugates in a variety of tissues:  assay development and evaluation of the distribu­tion of a brain-enhanced estradiol-chemical delivery system.  J. Steroid Biochem.  33:179-187, 1989.
  • DeVane C.L., J.W. Simpkins, R.L. Miller and S.B. Braun. Tissue distri­bution of cocaine in the pregnant rat.  Life Sciences 45:1271-1276, 1989.
  • Katovich, M.J., J.W. Simpkins and J. O'Meara. Effects of acute central LHRH administration on the skin temperature response in morphine depen­dent rats.  Brain Res. 494:85-94, 1989.
  • Brewster, M.E.,J.W. Simpkins, M. Singh, M. Hora and N. Bodor. Use of cyclodextrins in protein formulations.   J. Parenteral Science and Technology 43:231-240, 1989.

[1988]

  • Simpkins, J.W., Smulkowski, R. Dixon and R. Tuttle. Evidence for site‑specific delivery of narcotic antagonists to the colon as their glucuronide conjugates. J. Pharmacol. Expt. Therapeutics 244:195-205, 1988.
  • Anderson, W.R., J.W. Simpkins, M.E. Brewster and N. Bodor. Evidence for suppression of serum LH without elevation in serum estradiol and prolac­tin with a brain-enhanced redox delivery system for estradiol.  Life Sciences 42:1493-1502, 1988.
  • Anderson, W.R., J.W. Simpkins, M.E. Brewster and N. Bodor. Brain-Enhanced delivery of testosterone using a chemical delivery system complexed with 2-hydroxy-propyl-ß-cyclodextrin.  Drug Design and Deliv­ery 2:287-298, 1988.
  • Berglund, L.A., H. Derendorf and J.W. Simpkins. Desensitization of brain opiate receptor mechanisms by gonadal steroid hormone treatment which stimulates LH secretion.  Endocrinology 122:200-203, 1988.
  • Gabriel, S.M., J.T. Clark, P.S. Kalra, S.P. Kalra and J.W. Simpkins. Chronic morphine and testosterone treatment:  Effects on norepinephrine and serotonin metabolism and gonadotropin secretion in male rats.  Brain Res. 447:200-203, 1988.
  • Berglund, L.A. and J.W. Simpkins. Alterations in brain opiate receptor mechanisms on proestrous afternoon. Neuroendocrinology 48:394-400, 1988.
  • Clark, J.T., S.M. Gabriel, J.W. Simpkins, S.P. Kalra and P.S. Kalra. Chronic morphine and testosterone treatment:  effects on sexual behavior and dopamine metabolism in male rats.  Neuroendocrinology 48:97-104, 1988.
  • Anderson, W.R., J.W. Simpkins, M.E. Brewster and N. Bodor. Effects of a brain-enhanced chemical delivery system for estradiol on body weight and serum hormones in middle-aged male rats.  Endocrine Res. 14:131-148, 1988.
  • Simpkins, J.W., W.R. Anderson, R. Dawson, Jr., A. Seth, M. Brewster, K.S. Estes and N. Bodor. Chronic weight loss in lean and obese rats with a brain-enhanced chemical delivery system for estradiol.  Physiolo­gy and Behavior 44:573-580, 1988.

[1987]

  • Hart, K.N., F.W. Baser, J.W. Simpkins and R.M. Roberts. Effects of early pregnancy and acute 17ß‑estrogen administration on porcine uterine secretion, cyclic nucleotides and catecholamines.  Endocrinology 120, 254‑263, 1987.
  • Estes, K.S., M.E. Brewster, J.W. Simpkins and N. Bodor. A novel redox system for CNS‑directed delivery of estradiol causes sustained LH suppression in castrate rats.  Life Sciences 40, 1327‑1334, 1987.
  • Katovich, M.J., J.W. Simpkins, I‑C. Song and J. O'Meara. Effects of central application of naloxone on the skin temperature response in morphine‑dependent rats.  Brain Res. Bulletin 19, 81-85, 1987.
  • Anderson, W.R.,J. W. Simpkins, P.A. Woodard, D. Winwood W.C. Stern and N. Bodor. Anxiolytic activity of a Brain‑specific GABA delivery system.  Psychopharmacology 92, 157-163, 1987.
  • Gabriel, S.M., L.A. Berglund and J.W. Simpkins. Chronic morphine treatment enhances the negative and positive feedback effects of estra­diol on gonadotropin secretion in ovariectomized rats.  Endocrinology 120, 1799-1805, 1987.
  • Simpkins, J.W. and M.J. Katovich. Role of hypothermia in the pentobarbital‑induced blockade of LH secretion in female rats. Neuroen­docrinology 46, 217-221, 1987.
  • Anderson, W.R., J.W. Simpkins, M.E., Brewster and N. Bodor. Evidence for the reestablishment of copulatory behavior in castrated male rats with a brain‑enhanced estradiol‑chemical delivery system.  Pharmacology Biochemistry and Behavior 27, 265-271, 1987.
  • Katovich, M.J., J.W. Simpkins and C.C. Barney. Alpha‑adrenergic media­tion of the tail skin temperature response to naloxone in morphine‑dependent rats.  Brain Res. 426:55-61, 1987.
  • Simpkins, J.W. and W.J. Millard. Influence of Age on Neurotransmitter Function.  In, Endocrinology and Aging, Endocrine and Metabolic Clinics of North America, Vol 16, No. 14, Ed. Bertram Sacktor, W.B. Sanders Co., Philadelphia, PA, pp. 893-917, 1987.

[1986]

  • Simpkins, J.W. and M.J. Katovich. An animal model for pharmacologic evaluation of the menopausal hot flush.  In, The Climacteric in Prospec­tive, MTP Press, Boston, pp. 213‑251, 1986.
  • Katovich, M.J., J.W. Simpkins, L.A. Berglund and J. O'Meara. Regional skin temperature changes in a rat model for the hot flush. Maturitus 8, 67‑76, 1986.
  • Gabriel, S.M., L.A. Berglund and J.W. Simpkins. A decline in endogenous opioid influence during the steroid‑induced hypersecretion of luteiniz­ing hormone in the rat.  Endocrinology 118, 558‑561, 1986.
  • Able, A.M., M.W. McKenzie, J.W. Simpkins and O.E. Aranjo. A comparison of warm versus cold compresses in the treatment of doxorubison‑induced skin lesions in rats.  Fl. J. of Hospital Pharmacy 6, 129‑136, 1986.
  • Gabriel, S.M., L.A. Berglund, S.P. Kalra, P.S. Kalra and J.W. Simpkins. The influence of chronic morphine treatment on the negative feedback regulation of gonadotropin secretion by gonadal steroids.  Endocrinology 119, 2762‑2767, 1986.
  • Clark, J.T., J.W. Simpkins and S.P. Kalra. Long‑term weekly gonadal steroid treatment:  effects on plasma prolactin, sexual behavior and hypothalamic ‑ preoptic area catecholamines.  Neuroendocrinology 44, 488‑493, 1986.
  • Simpkins, J.W., J. McCornack, K.S. Estes, M.E. Brewster, E. Shek and N. Bodor. Sustained brain‑specific delivery of estradiol causes long‑term suppression of luteinizing hormone secretion.  Med. Chem. 29, 1809‑1812, 1986.
  • Katovich, M.J., J.W. Simpkins and J. O'Meara. Effects of opioid antago­nists and their quaternary analogues on temperature changes in morphine-­dependent rats.  Life Sciences 39, 1845‑1854, 1986.
  • L. DeVane and J.W. Simpkins, Placental transfer and Teratogenic effects of imipramine in the rat. In, Clinical Pharmacology and Psychi­atry IV: Selectivity in Drug Action, Eds. S.M. Paul, L.F. Gram, S. Dahl and W.Z. Potter, Springer‑Berkley, NY, pp. 174‑178, 1986.

[1985]

  • Simpkins, J.W.,P. Field, G. Torosian and E.E. Soltis. Effects of prenatal exposure to tricyclic antidepressants on adrenergic responses in progeny. Developmental Pharmacology and Therapeutics 8, 17‑33, 1985.
  • Simpkins, J.W.,J. Millard, S.M. Gabriel and E.E. Soltis. Noradrener­gic Methods in Neuroendocrinology. In, Pharmacological Methods in Neuroendocrinology, Ed. R.W. Steger, CRC Medical Press, Boca Raton, FL, pp. 1‑66, 1985.
  • Gabriel, S.M., J.W. Simpkins, S.P. Kalra and P.S. Kalra. Chronic mor­phine treatment induces hypersensitivity to testosterone negative feedback in castrated male rats. Neuroendocrinology 40, 39‑44, 1985.
  • Leaden, C.A., W.R. Crowley, J.W. Simpkins and S.P. Kalra. Effects of naloxone on catecholamine and LHRH release from perifused hypothalamus of steroid‑primed rats. Neuroendocrinology 40, 497‑500, 1985.
  • Simpkins, J.W., N. Bodor and A. Enz. Direct evidence for brain specific release of dopamine from a redox delivery system.  Pharm. Sci. 74, 1033‑1036, 1985.
  • Gabriel, S.M. J.W. Simpkins and W.J. Millard. Changes in anterior pituitary hormone secretion and hypothalamic catecholamine metabolism during morphine withdrawal in the female rat.  Brain Res. 346, 15‑21, 1985.
  • DeVane, C.L. and J.W. Simpkins. Pharmacokinetics of imipramine and its major metabolites in pregnant rats and their fetuses following a single dose.  Drug Metabolism and Disposition 13, 438‑442, 1985.
  • Katovich, M.J. and J.W. Simpkins. Role of dopamine in an animal model for the hot flush.  In, Homeostasis and Thermal Stress, 6th Intern. Symposium Pharmacol. Thermoregulation, Eds. Cooper, Lomax, Sconbaum and Veale; Karger Basal, pp.123‑128, 1985.

[1984]

  • Gabriel, S.M., J.W. Simpkins and W.J. Millard. The effects of chronic naloxone on pituitary hormone secretion in female rats. Brain Research Bulletin 12, 359‑362, 1984.
  • Simpkins, J.W., S.T. Taylor, S.M. Gabriel, M.J. Katovich and W.J. Millard. Evidence that chronic hyperprolactinemia effects skin tempera­ture regulation through an opioid mechanism. Neuroendocrinology 39, 321‑329, 1984.
  • Katovich, M.J., J.W. Simpkins, I.‑C Song, N. Bodor and R. Tuttle. A rapid quantitative in vivo assay for narcotic antagonists.  Substance and Alcohol Action/Misuse 5, 87‑95, 1984.
  • Simpkins, J.W. and S.M. Gabriel. Chronic hyperprolactinemia causes progressive changes in hypothalamic dopaminergic and noradrenergic neurons.  Brain Research 309, 277‑282, 1984.
  • Estes, K.S. and J.W. Simpkins. Age‑related alterations in catecholamine activity within microdissected brain regions of ovariectomized Fischer 344 rats.  J. Neuroscience Research 11, 405‑417, 1984.
  • Kalra, P.S., J.W. Simpkins and S.P. Kalra. Testosterone raise LHRH levels exclusively in the median eminence of castrated rats.  Neuroendo­crinology 39, 45‑48, 1984.
  • Simpkins, J.W. Spontaneous skin flushing episodes in the aging female rat.  Maturitus 6, 269‑278, 1984.
  • Simpkins, J.W. Critique of the role of serotonergic neurons in the phasic release of LH and in reproductive senescence. Neurobiology of Aging 5, 146‑149, 1984.
  • Simpkins, J.W. and K.S. Estes. Role of monoaminergic neurons in the age‑related alterations in anterior pituitary hormone secretion.  In, Peptides, Hormones and Behavior, Eds. C.B. Nemeroff and A.J. Dunn, Spectrum Publications: Medical and Scientific Books, pp. 823‑863, 1984.
  • Estes, K.S. and J.W. Simpkins. Age‑related alterations in dopamine and norepinephrine activity within microdissected brain regions of ovariec­tomized, Long Evans rats.  Brain Research 298, 209‑218, 1984.
  • DeVane, C.L., J.W. Simpkins and S.A. Stout. Cerebral and blood pharma­cokinetics of imipramine and its active metabolites in the pregnant rat.  Psychopharmacology 84, 225‑230, 1984.
  • Simpkins, J.W. Regional changes in dopamine metabolism in the aging constant estrous rat.  Neurobiology of Aging 5, 309‑313, 1984.

[1983]

  • Simpkins, J.W. Changes in hypothalamic hypophysiotropic hormones and neurotransmitters during aging.  In, Neuroendocrinology of Aging, Ed. J. Meites, Plenum Press, New York, pp. 41‑59, 1983.
  • Simpkins, J.W.,S. Estes, P.S. Kalra and S.P. Kalra. Alterations in hypothalamic neurotransmitters contribute to the age‑related decline in reproductive function in the male rat. In, Male Reproduction and Fertil­ity, Ed. A. Negro‑Vilar, Raven Press, New York, pp. 95‑109, 1983.
  • Simpkins, J.W., S.P. Kalra and P.S. Kalra. Variable effects of testos­terone on dopamine activity in several microdissected regions in the preoptic area and medial hypothalamus. Endocrinology 112, 665‑669, 1983.
  • Estes, K.S., J.W. Simpkins and S.P. Kalra. Normal LHRH neuronal func­tion and hyperprolactinemia in old pseudopregnant Fischer 344 rats.  Neurobiology of Aging 3, 247‑252, 1983.
  • Simpkins, J.W., M.J. Katovich and I.‑C Song. Similarities between morphine withdrawal in the rat and the menopausal hot flush.  Life Science 32, 1957‑1966, 1983.
  • Katovich, M.J. and J.W. Simpkins. Effects of chronic hyperprolactinemia on experimentally‑induced thirsts in male rats.  J. Physiology 341, 75‑83, 1983.
  • Simpkins, J.W.,P. Field and R.J. Ress. Age‑related decline in adrenergic responsiveness in several tissues of male rats. Neurobiology of Aging 4, 233‑238, 1983.
  • Millard, W.J., S.M. Sagar,J. W. Simpkins, R.E. Owens, T.M. Badger, H.G. Friesen and J.B. Martin. Cysteamine‑induced depletion of both immuno­logical and biological prolactin activity in the blood and anterior pituitary of the rat. Endocrinology 113, 2161‑2167, 1983.
  • Gabriel, S.M. and J.W. Simpkins. Effects of a sustained release nalox­one pellet on LH secretion in female rats. Neuroendocrinology 37, 342‑348, 1983.
  • Gabriel, S.M., J.W. Simpkins and S.P. Kalra. Modulation of endogenous opioid influence on LH secretion by progesterone and estrogen.  Endocri­nology 113, 1806‑1811, 1983.
  • Simpkins, J.W., K.S. Estes, W.J. Millard, R. Sagar and J.B. Martin. Cysteamine depletes prolactin in young and old hyperprolactinemic rats.  Endocrinology 112, 1889‑1891, 1983.
  • Bodor, N. and J.W. Simpkins. Brain‑specific, sustained release of dopamine with a redox delivery system.  Science 221, 65‑67, 1983.
  • Hodson, C.A., H.W. Burden, I.E. Lawrence and J.W. Simpkins. Depletion of tuberoinfundibular dopamine does not restore gonadotropin secretion in ovariectomized hyperprolactinemic rats. Life Science 33, 365‑370, 1983.
  • Kumar, M.S.A. and J.W. Simpkins. Naloxone blocks the effects of    9‑tetrahydrocannabinol on serum luteinizing hormone and prolactin in rats.  Substance and Alcohol Action/Misuse 4, 347‑353, 1983.
  • Kalra, P.S., J,W. Simpkins, W.G. D and S.P. Kalra. Effects on male sex behavior and preoptic dopamine neurons of hyperprolactinemia induced by MtTW15 pituitary tumors. Endocrinology 113, 2065‑2071, 1983.

[1982]

  • Estes, K.S.,J. W. Simpkins and S.P. Kalra. Resumption with clonidine of pulsatile LH release following acute norepinephrine depletion in ovariectomized rats. Neuroendocrinology 35, 56‑62, 1982.
  • Meites, J., H.H. Huang, J.W. Simpkins and R.W. Steger. Central nervous system neurotransmitters during the decline of reproductive activity.  In, The Menopause: Clinical, Endocrinological and Pathophysiological Aspects, Eds. L. Martini, G.B. Melis and S.S.C. Yen, Academic Press, New York, pp. 3‑13, 1982.
  • Simpkins, J.W.,A. Hodson, P.S. Kalra and S.P. Kalra. Chronic hyper­prolactinemia depletes hypothalamic dopamine concentrations in male rats.  Life Science 30, 1349‑1353, 1982.
  • Kumar, M.S.A., C.L. Chen, E.L. Besch, J.W. Simpkins and K.S. Estes. Altered hypothalamic dopamine depletion rate and LHRH content in noncyc­lic hamsters.  Brain Research Bulletin 8, 33‑36, 1982.
  • Simpkins, J.W. Regulation of thyroid stimulating hormone secretion.  In, Handbook of Endocrinology, Eds. G.H. Gass and H.M. Kaplan, CRC Medical Press, Inc., Boca Raton, FL, pp. 61‑69, 1982.
  • Estes, K.S. and J.W. Simpkins. Resumption of pulsatile LH release following ß‑adrenergic stimulation in aging constant estrous rats.  Endocrinology 111, 1778‑1784, 1982.

[1981]

  • Kalra, S.P., P.S. Kalra and J.W. Simpkins. Regulation of LHRH secretion by gonadal steroids and catecholamines.  In, Reproductive Processes and Contraception, Ed. K.M. McKerns, Plenum Press New York, pp. 27‑45, 1981.
  • Kalra, S.P., J.W. Simpkins and P.S. Kalra. Effects of pentobarbital on hypothalamic catecholamines and LHRH activity.  Acta Endocrinol. 95, 1‑6, 1981.
  • Kalra, S.P. and J.W. Simpkins. Evidence for nonadrenergic mediation of opioid effects on LH secretion.  Endocrinology 109, 776‑782, 1981.
  • Kalra, S.P., J.W. Simpkins and P.S. Kalra. Effects of pentobarbital on progesterone‑induced changes in hypothalamic LHRH and catecholamine turnover.  Endocrinology 108, 1298‑1304, 1981.
  • Simpkins, J.W., P.S. Kalra and S.P. Kalra. Alterations in daily rhythms of testosterone and progesterone in old male rats.  Experimental Aging Research 7, 25‑32, 1981.
  • Kalra, P.S., J.W. Simpkins and S.P. Kalra. Hyperprolactinemia counteracts the testosterone‑induced inhibition of preoptic area dopamine turnover.  Neuroendocrinology 33, 118‑122, 1981.

[1980]

  • Simpkins, J.W., P.S. Kalra and S.P. Kalra. Effects of testosterone on catecholamine turnover and LHRH content in the basal hypothalamus and preoptic area.  Neuroendocrinology 30, 94‑100, 1980.
  • Estes, K.S., J.W. Simpkins and C.L. Chen. Alteration in pulsatile release of LH in aging female rats.  Proc. Soc. Exp. Biol. Med. 163, 384‑387, 1980.
  • Hodson, C.A., J.W. Simpkins, K.A. Pass, C.F. Aylsworth, R.W. Steger and J. Meites. Effects of a prolactin secreting pituitary tumor on hypothalamic, gonadotropic and testicular function in male rats.  Neuroendocrinology 30, 7‑10, 1980.
  • Estes, K.S. and J.W. Simpkins. Age‑related alterations in catecholamine concentrations in discrete preoptic area and hypothalamic regions in the male rat.  Brain Research 194, 556‑560, 1980.
  • Simpkins, J.W., P.S. Kalra and S.P. Kalra. Temporal alterations in LHRH concentrations in several brain nuclei: effects of estrogen‑progesterone and norepinephrine synthesis inhibition.  Endocrinology 107, 573‑577, 1980.
  • Simpkins, J.W., P.S. Kalra and S.P. Kalra. Inhibitory effects of androgens on preoptic area dopaminergic neurons in castrate male rats.  Neuroendocrinology 31, 177‑181, 1980.
  • Lu, K.H., J.W. Simpkins, H.T. Chen and J. Meites. Patterns of pituitary LH release during sustained stimulation by synthetic LRF in cycling female rats.  Materia Medica Polona 42, 63‑69, 1980.
  • Kalra, S.P., J.W. Simpkins and C.L. Chen. The Opioid‑Catecholamine Modulation of Gonadotropin and Prolactin Secretion.  In, Functional Correlates of Hormone Receptors in Reproduction, Eds. V.B. Mahesh, T.G. Muldoon, B.B. Saxena and W.A. Sadler, Elsevier/North Holland Press, New York, pp. 135‑149, 1980.

[1979]

  • Advis, J.P., J.W. Simpkins, J. Bennett and J. Meites. Serotonergic control of prolactin secretion. Life Science 24, 359‑366, 1979.
  • Simpkins, J.W.,P. Advis, C.A. Hodson and J. Meites. Blockade of steroid induced LH release by selective depletion of anterior hypothalamic norepinephrine activity.  Endocrinology 104, 506‑509, 1979.
  • Simpkins, J.W., H.H. Huang, J.P. Advis, and J. Meites. Evaluation of changes in NE and DA turnover during progesterone induced LH and prolactin surges in ovariectomized, estrogen primed rats. Biology of Reproduction 20, 625‑632, 1979.
  • Meites, J., J.W. Simpkins and H.H. Huang. The relation of hypothalamic biogenic amines to secretion of gonadotropins and prolactin in aging rats.  In, Physiology and Cell Biology of Aging, (Aging, vol. 8), Ed. A. Cherkin, Raven Press, New York, pp. 87‑94, 1979.
  • Meites, J., G.P. Mueller, J.W. Simpkins, C.A. Hodson, and K.E. Moore. Effects of piribedil and other dopamine agonists on secretion of anterior pituitary hormones.  Psycholegie Medicale 11, 255‑262, 1979.
  • Simpkins, J.W. and S.P. Kalra. Blockade of progesterone‑induced increase in hypothalamic luteinizing hormone‑releasing hormone levels 6‑hydroxy‑dopamine.  Brain Research 170, 475‑484, 1979.

[1978]

  • Meites, J., K.H. Lu, L. Grandison, C.A. Hodson and J.W. Simpkins. Relation of prolactin to gonadotropin secretion during postpartum lactation and after castration.  In, Progress in Prolactin Physiology and Pathology, Eds. C. Robyn and M. Harter Elsevier/North Holland, Amsterdam, pp. 149‑164, 1978.
  • Advis, J.P., J.W. Simpkins, H.T. Chen and J. Meites. Relation of biogenic amines to onset of puberty in female rats. Endocrinology 103, 11‑16, 1978.
  • Hodson, C.A., J.W. Simpkins and J. Meites. Inhibition of LH release and LHRH action by the ovaries of postpartum lactating rats.  Endocrinology 102, 832‑836, 1978.
  • Simpkins, J.W.,A. Hodson and J. Meites. Differential effects of stress on release of thyroid‑stimulating hormone in young and old male rats.  Proc. Soc. Exp. Biol. Med. 157, 144‑147, 1978.
  • Hodson, C.A., J.W. Simpkins and J. Meites. Effects of brain serotonin reduction on growth of carcinogen‑induced mammary tumors in rats.  IRCS Med. Sci. 6, 398, 1978.

[1977]

  • Simpkins, J.W., G.P. Mueller, H.H. Huang and J. Meites. Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: possible relation to gonadotropin secretion. Endocrinology 100, 1672‑1678, 1977.
  • Meites, J., J.W. Simpkins, J.F. Bruni and J.P. Advis.  Role of biogenic amines in control of anterior pituitary hormones.  IRCS Medical Science 5, 1‑7, 1977.
  • Chen, H.T., J.W. Simpkins, G.P. Mueller and J. Meites.  Effects of pargyline on hypothalamic biogenic amines and serum prolactin, LH and TSH in male rats.  Life Science 21, 533‑542, 1977.
  • Meites, J., H.H. Huang and J.W. Simpkins. Recent studies on neuroendocrine control of reproductive senescence in rats.  In, The Aging Reproductive System, Ed. E.L. Schneider, Raven Press, New York, pp. 213‑235, 1977.
  • Turner, J.W. and J.W. Simpkins. Effect of hypothalamic lesions and androgen on plasma LH in castrated male rat. Neuroendocrinology 24, 80‑89, 1977.
  • Grandison, L., C.A. Hodson, H.T. Chen, J.P. Advis, J.W. Simpkins and J. Meites. Inhibition by prolactin of post‑castration rise in LH.  Neuroendocrinology 23, 312‑322, 1977.

[1976]

  • Simpkins, J.W. and C.J.V. Smith. The temporal interaction of corticosterone and prolactin in affecting liver lipid metabolism of the chick.  Poultry Science 55:728-734, 1976.
  • Simpkins, J.W.,F. Bruni, R.J. Miduszewski and J. Meites. Serum and pituitary TSH and response to TRH in developing male and female rats. Endocrinology 98, 1365‑1369, 1976.
  • Mueller, G.P., J.W. Simpkins, J. Meites and K.E. Moore. Differential effects of dopamine agonists and haloperidol on release on prolactin, thyroid stimulating hormone, growth hormone and luteinizing hormone in rats. Neuroendocrinology 20, 121‑135, 1976.
  • Grandison, L., J.P. Adivs, C.A. Hodson, J.W. Simpkins and J. Meites. Effects of prolactin on post‑castration LH release. IRCS Medical Science 4, 427, 1976.
  • Gudelsky, G.A., J.W. Simpkins, G.P. Mueller, J. Meites and K.E. Moore. Selective effect of prolactin on dopamine turnover in the hypothalamus and on serum LH and FSH.  Neuroendocrinology 22, 206‑215, 1976.