Our laboratory is interested in elucidating the neural mechanisms underlying asthma, especially with regard to early developmental changes that impact disease progression. Environmental triggers early in life can lead to a predisposition to asthma. Increased instances of asthma especially in children have highlighted the need for a better understanding of the biological changes in the lungs that produce asthma, especially during childhood.
Neuronal changes associated with inhaled in both outdoor (ozone, diesel exhaust) and indoor (cigarette smoke, wood smoke) pollutant may contribute to the long term development of the symptoms associated with asthma inflammation and hyper responsiveness. By investigating the links between irritants and neuron signaling we hope to discover targets for therapeutic intervention that will reduce or alleviate asthma in children and adults.